635318-11-5

635318-11-5结构式

中文名	(1R,4S,5S,6S)-4-氨基-2-硫杂双环[3.1.0]己烷-4,6-二甲酸 2,2-二氧化物
英文名	(1R,4S,5S,6S)-4-amino-2,2-dioxo-2λ6-thia-bicyclo[3.1.0]hexane-4,6-dicarboxylic acid
中文别名	LY2140023 5mg试剂 (1R,4S,5S,6S)-4-氨基-2-硫杂双环[3.1.0]己烷-4,6-二甲酸 2,2-二氧化物 2 pomaglumetad (LY404039) 试剂
英文别名	LY-404039 //BP pomaglumetad (1R,4S,5S,6S)-4-Amino-2-thiabicyclo[3.1.0]hexane-4,6-dicboxylic acid 2,2-dioxide 2-Thiabicyclo[3.1.0]hexane-4,6-dicboxylicacid, 4-amino-, 2 LY2140023 LY-404039C LY-404,039 (1R,4S,5S)-4-amino-2-thiabicyclo[3.1.0]hexane-4,6-dicboxylic acid 2,2-dioxide (1R,4S,5S,6S)-4-AMINO-2-THIABICYCLO 3.1.0 HEXANE-4,6-DICBOXYLIC ACID 2,2-DIOXIDE LY-404039 (LY (1R,4S,5S,6S)-4-Amino-2-thiabicyclo[3.1.0]hexane-4,6-dicarboxylic acid 2,2-dioxide LY404039 >= (HPLC) 4-Amino-2-thiabicyclo(3.1.0)hexane-4,6-dicboxylic acid LY2140023/LY404039 LY 404039; LY404039 LY-404039 2-Thiabicyclo[3.1.0]hexane-4,6-dicboxylic acid, 4-amino-, 2,2-dioxide, (1R,4S,5S,6S) (1R,4S,5S,6S)-4-[[(2S)-2-Amino-4-(methylthio)-1-oxobutyl]amino]-2-thiabicyclo[3.1.0]hexane-4,6-dicboxylic acid 2,2-dioxide LY404039, 10 mM in DMSO Pomaglumetad (LY404039) POMAGLUMETAD;LY2140023 pomaglumetad (LY404039) ，S6001

描述	LY404039是mGluR1和mGluR2的抑制剂,Ki分别为149 nM和92 nM,还能抑制多巴胺受体。
相关类别	信号通路 >> G 蛋白偶联受体/G 蛋白 >> 谷氨酸受体研究领域 >> 神经疾病
参考文献	[1]. Rorick-Kehn LM, Johnson BG, Burkey JL, Pharmacological and pharmacokinetic properties of a structurally novel, potent, and selective metabotropic glutamate 2/3 receptor agonist: in vitro characterizationofagonist(-)-(1R,4S,5S,6S)-4-amino-2-sulfonylbicyclo[3.1.0]-hexane-4,6-dicarboxylic acid (LY404039). J Pharmacol Exp Ther. 2007 Apr;321(1):308-17. [2]. Seeman P. An agonist at glutamate and dopamine D2 receptors, LY404039. Neuropharmacology. 2013 Mar;66:87-8. [3]. Rorick-Kehn LM, Johnson BG, Knitowski KM, In vivo pharmacological characterization of the structurally novel, potent, selective mGlu2/3 receptor agonistLY404039 in animal models of psychiatric disorders. Psychopharmacology (Berl). 2007 Jul;193(1):121-36.