137071-32-0

• 常用中文名：吡美莫司
• 常用英文名：Pimecrolimus
• CAS号：137071-32-0
• 分子式：C₄₃H₆₈ClNO₁₁
• 分子量：810.453
• 相关类别： 生物化工 抑制剂 免疫抑制剂
• 发布时间：2018-05-31 08:00:00
• 更新时间：2026-06-30 20:58:11
• Pimecrolimus是免疫亲和素(immunophilin)配体,能特异地与胞质受体(immunophilin macrophilin-12)相结合。

名称

• 中文名: 吡美莫司
• 英文名: Pimecrolimus
• 中文别名: 吡美莫司/匹美克莫司; 吡美莫司杂质; (3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26AS)-3-[(1E)-2-[(1R,3R,4S)-4-氯-3-甲氧基环己基]-1-甲基亚乙基]-8-乙基-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26A-十六氢-5,19-二羟基-14,16-二甲氧基-4,10,12,18-四甲基-15,19-环氧-3H-吡啶并[2,1-C][1,4]氧杂氮杂环二十三烷-1,7,20,21(4H,23H)-四酮; 匹美莫司; 吡美罗莫司; 吡美莫司 CRS; 抑制剂Pimecrolimus; 吡美莫司对照品; 吡美莫司(匹美克莫司、吡美莫司、匹美莫司); Pimecrolimus 10mM * 1mL in DMSO试剂; 吡美莫司,10 MM DMSO 溶液; 吡美莫司/137-0; 匹美克莫司; PIMECROLIMUS吡美莫司; 甲醇中吡美莫司
• 英文别名: Pimecrolimus CRS; Pimecrolimu; PiMecroliMus(Elidel); 33-epi-chloro-33-desoxy-ascomycin; Pimecrolimus INN; Picrolimus; PiMecroliMus(Elidel, SDZ-ASM-981); 15,19-oxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone, 3-[(1E)-2-[(1R,3R,4S)-4-chloro-3-methoxycyclohexyl]-1-methylethenyl]-8-ethyl-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-14,16-dimethoxy-4,10,12,18-tetramethyl-, (3S,4R,5S,8R,9E,12S,14S,15; ASM 981; SDZ-ASM; Unii-7kyv; 15,19-oxy-3H-pyrido(2,1-C)(1,4)oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone, 3-(2-(4-chloro-3-methoxycyclohexyl)-1-methylethenyl)-8-ethyl-, 5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26A-hexadecahydro-5,19-dihydroxy-14,16-dimethoxy-4,10,12,18-tetramethyl-, (3S-(3R*(E(1S*,3S*,4R*)),4S*,5R*,8S*,9E,12R*,14R*,15S*,16R*,18S*,19S*,26*)); (9E)-3S-[(1E)-2-[(1R,3R,4S)-4R-chloro-3-methoxycyclohexyl]-1-methylethenyl]-8-ethyl-5S,6,8R,11,12S,13,14S,15R,16S,17,18R,19R,24,25,26,26aS-hexadecahydro-5,19-dihydroxy-14,16-dimethoxy-4,10,12,18-tetramethyl-15,19; 15,19-oxy-3H-pyrido(2,1-C)(1,4)oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone, 3-((1E)-2-((1R,3R,4S)-4-chloro-3-methoxycyclohexyl)-1-methylethenyl)-8-ethyl-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26A-hexadecahydro-5,19-dihydroxy-14,16-dimethoxy-4,10,12,18-tetramethyl-, (3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26as); Pimerolimus; US-DMF No.; SDZ-ASM 981; Elidel; Pimecrolimus //BP; Elidel,SDZ-ASM-981; 33-epi-33-chloro-FR 520; (3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-3-[(1E)-2-[(1R,3R,4S)-4-Chloro-3-methoxycyclohexyl]-1-methylethenyl]-8-ethyl-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-14,16-dimethoxy-4,10,12,18-tetramethyl-15,19-oxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone; 15,19-oxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone, 3-[(1E)-2-[(1R,3R,4S)-4-chloro-3-methoxycyclohexyl]-1-methylethenyl]-8-ethyl-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-1; (3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-3-[(1E)-2-[(1R,3R,4S)-4-Chloro-3-methoxycyclohexyl]-1-methylethenyl]-8-ethyl-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-14,16-dimethoxy-4,10,12,18-tetramethyl-15,19-oxy-3H-pyr; (1R,9S,12S,13R,14S,17R,18E,21S,23S,24R,25S,27R)-12-{(1E)-1-[(1R,3R,4S)-4-Chloro-3-methoxycyclohexyl]-1-propen-2-yl}-17-ethyl-1,14-dihydroxy-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatri ;cyclo[22.3.1.0]octacos-18-ene-2,3,10,16-tetrone; Pimecrolimus, 10 mM in DMSO; Pimecrolinus

物化性质

• 密度: 1.2±0.1 g/cm3
• 沸点: 866.1±75.0 °C at 760 mmHg
• 分子式: C₄₃H₆₈ClNO₁₁
• 分子量: 810.453
• 闪点: 477.6±37.1 °C
• 精确质量: 809.448120
• PSA: 158.13000
• LogP: 5.08
• 外观性状: 白色结晶粉末
• 蒸汽压: 0.0±0.6 mmHg at 25°C
• 折射率: 1.543
• 储存条件: -20°C Freezer

生物活性

• 描述: Pimecrolimus是免疫亲和素(immunophilin)配体,能特异地与胞质受体(immunophilin macrophilin-12)相结合。
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 炎症/免疫
• 参考文献:

  [1]. Nghiem, P., G. Pearson, and R.G. Langley, Tacrolimus and pimecrolimus: from clever prokaryotes to inhibiting calcineurin and treating atopic dermatitis. J Am Acad Dermatol, 2002. 46(2): p. 228-41.

  [2]. Gupta, A.K. and M. Chow, Pimecrolimus: a review. J Eur Acad Dermatol Venereol, 2003. 17(5): p. 493-503.

  [3]. Stuetz, A., M. Grassberger, and J.G. Meingassner, Pimecrolimus (Elidel, SDZ ASM 981)--preclinical pharmacologic profile and skin selectivity. Semin Cutan Med Surg, 2001. 20(4): p. 233-41.

安全

• 危害码 (欧洲): Xi
• 危险品运输编码: NONH for all modes of transport

合成路线

135635-46-0 ~47% 137071-32-0

文献：Grassberger, Maximilian; Horvath, Amarylla Patent: US2008/71082 A1, 2008 ; Location in patent: Page/Page column 3 ;

148146-56-9 ~% 137071-32-0

文献：WO2006/60614 A1, ; Page/Page column 13 ;

1178863-99-4 ~39% 137071-32-0

文献：Ferraboschi, Patrizia; Colombo, Diego; De Mieri, Maria; Grisenti, Paride Tetrahedron Letters, 2009 , vol. 50, # 30 p. 4384 - 4388

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