毒理学数据:
1.急性毒性
LD50：150~180mg/kg（大鼠经口）
2.刺激性
家兔经皮：500mg（24h），轻度刺激。
家兔经眼：100mg（24h），中度刺激。
3.亚急性与慢性毒性 多次重复染毒，几乎全部动物发生周围神经损害，表现四肢肌肉无力、后肢严重瘫痪、肢体远端肌肉萎缩、感觉障碍及腱反射消失。
4.致敏性 对皮肤有致敏作用。
致突变性 姐妹染色单体交换：大鼠经口600mg/kg（连续10d）。精子形态学改变：小鼠腹腔注射100mg/kg。
5.致畸性 雌性小鼠受孕后6~17d，经口染毒540mg/kg，引发仔鼠肌肉骨骼系统发育畸形。
6.致癌性 IARC致癌性评论：G2A，可能人类致癌物。
7.其他 大鼠经口最低中毒剂量（TDLo）：200mg/kg（孕7~16d），引起新生鼠生化和代谢改变。大鼠经口最低中毒剂量（TDLo）：544mg/kg（9周，雄性），引起精子、雄性生育指数改变和植入后死亡率增加。
生态学数据:
1.生态毒性
LC50：103~115mg/L（96h）（黑头呆鱼）；110mg/L（96h）（虹鳟鱼）；100mg/L（96h）（蓝鳃太阳鱼）；160mg/L（48h）（水蚤）
2.生物降解性 暂无资料
3.非生物降解性 空气中，当羟基自由基浓度为5.00×105个/cm3时，降解半衰期为1.4d（理论）。
CHEMICAL IDENTIFICATION
-
RTECS NUMBER :
-
AS3325000
-
CHEMICAL NAME :
-
Acrylamide
-
CAS REGISTRY NUMBER :
-
79-06-1
-
BEILSTEIN REFERENCE NO. :
-
0605349
-
LAST UPDATED :
-
199712
-
DATA ITEMS CITED :
-
140
-
MOLECULAR FORMULA :
-
C3-H5-N-O
-
MOLECULAR WEIGHT :
-
71.09
-
WISWESSER LINE NOTATION :
-
ZV1U1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
-
TYPE OF TEST :
-
Standard Draize test
-
ROUTE OF EXPOSURE :
-
Administration onto the skin
-
SPECIES OBSERVED :
-
Rodent - rabbit
-
TYPE OF TEST :
-
Standard Draize test
-
ROUTE OF EXPOSURE :
-
Administration onto the skin
-
SPECIES OBSERVED :
-
Rodent - rabbit
-
TYPE OF TEST :
-
Rinsed with water
-
ROUTE OF EXPOSURE :
-
Administration into the eye
-
SPECIES OBSERVED :
-
Rodent - rabbit
-
TYPE OF TEST :
-
Standard Draize test
-
ROUTE OF EXPOSURE :
-
Administration into the eye
-
SPECIES OBSERVED :
-
Rodent - rabbit
-
TYPE OF TEST :
-
LD50 - Lethal dose, 50 percent kill
-
ROUTE OF EXPOSURE :
-
Oral
-
SPECIES OBSERVED :
-
Rodent - rat
-
DOSE/DURATION :
-
124 mg/kg
-
TOXIC EFFECTS :
-
Details of toxic effects not reported other than lethal dose value
-
TYPE OF TEST :
-
LD50 - Lethal dose, 50 percent kill
-
ROUTE OF EXPOSURE :
-
Administration onto the skin
-
SPECIES OBSERVED :
-
Rodent - rat
-
DOSE/DURATION :
-
400 mg/kg
-
TOXIC EFFECTS :
-
Blood - other changes Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - peptidases
-
TYPE OF TEST :
-
LD50 - Lethal dose, 50 percent kill
-
ROUTE OF EXPOSURE :
-
Intraperitoneal
-
SPECIES OBSERVED :
-
Rodent - rat
-
DOSE/DURATION :
-
90 mg/kg
-
TOXIC EFFECTS :
-
Details of toxic effects not reported other than lethal dose value
-
TYPE OF TEST :
-
LD50 - Lethal dose, 50 percent kill
-
ROUTE OF EXPOSURE :
-
Unreported
-
SPECIES OBSERVED :
-
Rodent - rat
-
DOSE/DURATION :
-
208 mg/kg
-
TOXIC EFFECTS :
-
Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Behavioral - changes in motor activity (specific assay)
-
TYPE OF TEST :
-
LD50 - Lethal dose, 50 percent kill
-
ROUTE OF EXPOSURE :
-
Oral
-
SPECIES OBSERVED :
-
Rodent - mouse
-
DOSE/DURATION :
-
107 mg/kg
-
TOXIC EFFECTS :
-
Details of toxic effects not reported other than lethal dose value
-
TYPE OF TEST :
-
LD50 - Lethal dose, 50 percent kill
-
ROUTE OF EXPOSURE :
-
Intraperitoneal
-
SPECIES OBSERVED :
-
Rodent - mouse
-
DOSE/DURATION :
-
170 mg/kg
-
TOXIC EFFECTS :
-
Details of toxic effects not reported other than lethal dose value
-
TYPE OF TEST :
-
LD50 - Lethal dose, 50 percent kill
-
ROUTE OF EXPOSURE :
-
Unreported
-
SPECIES OBSERVED :
-
Rodent - mouse
-
DOSE/DURATION :
-
156 mg/kg
-
TOXIC EFFECTS :
-
Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Behavioral - changes in motor activity (specific assay)
-
TYPE OF TEST :
-
LD50 - Lethal dose, 50 percent kill
-
ROUTE OF EXPOSURE :
-
Oral
-
SPECIES OBSERVED :
-
Rodent - rabbit
-
DOSE/DURATION :
-
150 mg/kg
-
TOXIC EFFECTS :
-
Details of toxic effects not reported other than lethal dose value
-
TYPE OF TEST :
-
LD50 - Lethal dose, 50 percent kill
-
ROUTE OF EXPOSURE :
-
Administration onto the skin
-
SPECIES OBSERVED :
-
Rodent - rabbit
-
DOSE/DURATION :
-
1680 uL/kg
-
TOXIC EFFECTS :
-
Behavioral - hallucinations, distorted perceptions
-
TYPE OF TEST :
-
LD50 - Lethal dose, 50 percent kill
-
ROUTE OF EXPOSURE :
-
Unreported
-
SPECIES OBSERVED :
-
Rodent - rabbit
-
DOSE/DURATION :
-
280 mg/kg
-
TOXIC EFFECTS :
-
Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Behavioral - changes in motor activity (specific assay)
-
TYPE OF TEST :
-
LD50 - Lethal dose, 50 percent kill
-
ROUTE OF EXPOSURE :
-
Oral
-
SPECIES OBSERVED :
-
Rodent - guinea pig
-
DOSE/DURATION :
-
150 mg/kg
-
TOXIC EFFECTS :
-
Details of toxic effects not reported other than lethal dose value
-
TYPE OF TEST :
-
LD50 - Lethal dose, 50 percent kill
-
ROUTE OF EXPOSURE :
-
Subcutaneous
-
SPECIES OBSERVED :
-
Rodent - guinea pig
-
DOSE/DURATION :
-
170 mg/kg
-
TOXIC EFFECTS :
-
Behavioral - tremor Behavioral - muscle contraction or spasticity Gastrointestinal - nausea or vomiting
-
TYPE OF TEST :
-
LD50 - Lethal dose, 50 percent kill
-
ROUTE OF EXPOSURE :
-
Unreported
-
SPECIES OBSERVED :
-
Rodent - guinea pig
-
DOSE/DURATION :
-
173 mg/kg
-
TOXIC EFFECTS :
-
Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Behavioral - changes in motor activity (specific assay)
-
TYPE OF TEST :
-
LD50 - Lethal dose, 50 percent kill
-
ROUTE OF EXPOSURE :
-
Oral
-
SPECIES OBSERVED :
-
Bird - quail
-
DOSE/DURATION :
-
186 mg/kg
-
TOXIC EFFECTS :
-
Peripheral Nerve and Sensation - flaccid paralysis without anesthesia (usually neuromuscular blockage) Behavioral - altered sleep time (including change in righting reflex) Behavioral - changes in motor activity (specific assay)
-
TYPE OF TEST :
-
LD50 - Lethal dose, 50 percent kill
-
ROUTE OF EXPOSURE :
-
Oral
-
SPECIES OBSERVED :
-
Mammal - species unspecified
-
DOSE/DURATION :
-
100 mg/kg
-
TOXIC EFFECTS :
-
Details of toxic effects not reported other than lethal dose value
-
TYPE OF TEST :
-
LDLo - Lowest published lethal dose
-
ROUTE OF EXPOSURE :
-
Intravenous
-
SPECIES OBSERVED :
-
Mammal - species unspecified
-
DOSE/DURATION :
-
190 mg/kg
-
TOXIC EFFECTS :
-
Details of toxic effects not reported other than lethal dose value
-
TYPE OF TEST :
-
TDLo - Lowest published toxic dose
-
ROUTE OF EXPOSURE :
-
Oral
-
SPECIES OBSERVED :
-
Rodent - rat
-
DOSE/DURATION :
-
1035 mg/kg/15W-I
-
TOXIC EFFECTS :
-
Behavioral - muscle weakness Behavioral - ataxia Nutritional and Gross Metabolic - weight loss or decreased weight gain
-
TYPE OF TEST :
-
TDLo - Lowest published toxic dose
-
ROUTE OF EXPOSURE :
-
Oral
-
SPECIES OBSERVED :
-
Rodent - rat
-
DOSE/DURATION :
-
608 mg/kg/16D-C
-
TOXIC EFFECTS :
-
Spinal Cord - other degenerative changes Nutritional and Gross Metabolic - weight loss or decreased weight gain
-
TYPE OF TEST :
-
TDLo - Lowest published toxic dose
-
ROUTE OF EXPOSURE :
-
Oral
-
SPECIES OBSERVED :
-
Rodent - rat
-
DOSE/DURATION :
-
1800 mg/kg/90D-C
-
TOXIC EFFECTS :
-
Peripheral Nerve and Sensation - structural change in nerve or sheath Behavioral - fluid intake Nutritional and Gross Metabolic - weight loss or decreased weight gain
-
TYPE OF TEST :
-
TDLo - Lowest published toxic dose
-
ROUTE OF EXPOSURE :
-
Oral
-
SPECIES OBSERVED :
-
Rodent - rat
-
DOSE/DURATION :
-
600 mg/kg/6W-C
-
TOXIC EFFECTS :
-
Behavioral - changes in motor activity (specific assay) Behavioral - ataxia
-
TYPE OF TEST :
-
TDLo - Lowest published toxic dose
-
ROUTE OF EXPOSURE :
-
Oral
-
SPECIES OBSERVED :
-
Rodent - rat
-
DOSE/DURATION :
-
286 mg/kg/28D-C
-
TOXIC EFFECTS :
-
Brain and Coverings - changes in brain weight Cardiac - changes in heart weight Blood - pigmented or nucleated red blood cells
-
TYPE OF TEST :
-
TDLo - Lowest published toxic dose
-
ROUTE OF EXPOSURE :
-
Intraperitoneal
-
SPECIES OBSERVED :
-
Rodent - rat
-
DOSE/DURATION :
-
108 mg/kg/3W-I
-
TOXIC EFFECTS :
-
Brain and Coverings - other degenerative changes Spinal Cord - other degenerative changes Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - multiple enzyme effects
-
TYPE OF TEST :
-
TDLo - Lowest published toxic dose
-
ROUTE OF EXPOSURE :
-
Intraperitoneal
-
SPECIES OBSERVED :
-
Rodent - rat
-
DOSE/DURATION :
-
168 mg/kg/2W-C
-
TOXIC EFFECTS :
-
Behavioral - muscle weakness
-
TYPE OF TEST :
-
TDLo - Lowest published toxic dose
-
ROUTE OF EXPOSURE :
-
Intraperitoneal
-
SPECIES OBSERVED :
-
Rodent - rat
-
DOSE/DURATION :
-
780 mg/kg/13W-I
-
TOXIC EFFECTS :
-
Spinal Cord - demyelination Peripheral Nerve and Sensation - structural change in nerve or sheath Behavioral - ataxia
-
TYPE OF TEST :
-
TDLo - Lowest published toxic dose
-
ROUTE OF EXPOSURE :
-
Intraperitoneal
-
SPECIES OBSERVED :
-
Rodent - rat
-
DOSE/DURATION :
-
400 mg/kg/8D-I
-
TOXIC EFFECTS :
-
Brain and Coverings - other degenerative changes Spinal Cord - other degenerative changes Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other transferases
-
TYPE OF TEST :
-
TDLo - Lowest published toxic dose
-
ROUTE OF EXPOSURE :
-
Subcutaneous
-
SPECIES OBSERVED :
-
Rodent - rat
-
DOSE/DURATION :
-
1155 mg/kg/13W-I
-
TOXIC EFFECTS :
-
Peripheral Nerve and Sensation - sensory change involving peripheral nerve Peripheral Nerve and Sensation - recording from peripheral motor nerve Nutritional and Gross Metabolic - weight loss or decreased weight gain
-
TYPE OF TEST :
-
TDLo - Lowest published toxic dose
-
ROUTE OF EXPOSURE :
-
Subcutaneous
-
SPECIES OBSERVED :
-
Rodent - rat
-
DOSE/DURATION :
-
1 gm/kg/8W-I
-
TOXIC EFFECTS :
-
Peripheral Nerve and Sensation - spastic paralysis with or without sensory change Peripheral Nerve and Sensation - structural change in nerve or sheath
-
TYPE OF TEST :
-
TDLo - Lowest published toxic dose
-
ROUTE OF EXPOSURE :
-
Oral
-
SPECIES OBSERVED :
-
Rodent - mouse
-
DOSE/DURATION :
-
568 mg/kg/8W-I
-
TOXIC EFFECTS :
-
Related to Chronic Data - changes in testicular weight
-
TYPE OF TEST :
-
TDLo - Lowest published toxic dose
-
ROUTE OF EXPOSURE :
-
Intraperitoneal
-
SPECIES OBSERVED :
-
Rodent - mouse
-
DOSE/DURATION :
-
1200 mg/kg/4W-I
-
TOXIC EFFECTS :
-
Behavioral - muscle weakness Related to Chronic Data - death
-
TYPE OF TEST :
-
TDLo - Lowest published toxic dose
-
ROUTE OF EXPOSURE :
-
Oral
-
SPECIES OBSERVED :
-
Mammal - dog
-
DOSE/DURATION :
-
330 mg/kg/22D-I
-
TOXIC EFFECTS :
-
Peripheral Nerve and Sensation - recording from peripheral motor nerve Behavioral - muscle weakness Behavioral - ataxia
-
TYPE OF TEST :
-
TDLo - Lowest published toxic dose
-
ROUTE OF EXPOSURE :
-
Oral
-
SPECIES OBSERVED :
-
Primate - monkey
-
DOSE/DURATION :
-
671 mg/kg/75W-I
-
TOXIC EFFECTS :
-
Autonomic Nervous System - other (direct) parasympathomimetic Behavioral - changes in motor activity (specific assay) Related to Chronic Data - death
-
TYPE OF TEST :
-
TDLo - Lowest published toxic dose
-
ROUTE OF EXPOSURE :
-
Oral
-
SPECIES OBSERVED :
-
Primate - monkey
-
DOSE/DURATION :
-
450 mg/kg/61D-I
-
TOXIC EFFECTS :
-
Peripheral Nerve and Sensation - sensory change involving peripheral nerve
-
TYPE OF TEST :
-
TDLo - Lowest published toxic dose
-
ROUTE OF EXPOSURE :
-
Intraperitoneal
-
SPECIES OBSERVED :
-
Primate - monkey
-
DOSE/DURATION :
-
200 mg/kg/2D-I
-
TOXIC EFFECTS :
-
Lungs, Thorax, or Respiration - chronic pulmonary edema Liver - fatty liver degeneration Related to Chronic Data - death
-
TYPE OF TEST :
-
TDLo - Lowest published toxic dose
-
ROUTE OF EXPOSURE :
-
Intravenous
-
SPECIES OBSERVED :
-
Primate - monkey
-
DOSE/DURATION :
-
200 mg/kg/4D-I
-
TOXIC EFFECTS :
-
Related to Chronic Data - death
-
TYPE OF TEST :
-
TDLo - Lowest published toxic dose
-
ROUTE OF EXPOSURE :
-
Oral
-
SPECIES OBSERVED :
-
Mammal - cat
-
DOSE/DURATION :
-
771 mg/kg/1Y-I
-
TOXIC EFFECTS :
-
Behavioral - muscle weakness
-
TYPE OF TEST :
-
TDLo - Lowest published toxic dose
-
ROUTE OF EXPOSURE :
-
Subcutaneous
-
SPECIES OBSERVED :
-
Mammal - cat
-
DOSE/DURATION :
-
150 mg/kg/10D-I
-
TOXIC EFFECTS :
-
Brain and Coverings - other degenerative changes Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - dehydrogenases Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other Enzymes
-
TYPE OF TEST :
-
TDLo - Lowest published toxic dose
-
ROUTE OF EXPOSURE :
-
Intramuscular
-
SPECIES OBSERVED :
-
Mammal - cat
-
DOSE/DURATION :
-
300 mg/kg/10D-I
-
TOXIC EFFECTS :
-
Spinal Cord - other degenerative changes Behavioral - muscle weakness
-
TYPE OF TEST :
-
TDLo - Lowest published toxic dose
-
ROUTE OF EXPOSURE :
-
Oral
-
SPECIES OBSERVED :
-
Bird - chicken
-
DOSE/DURATION :
-
450 mg/kg/3W-I
-
TOXIC EFFECTS :
-
Behavioral - muscle weakness Behavioral - ataxia
-
TYPE OF TEST :
-
TDLo - Lowest published toxic dose
-
ROUTE OF EXPOSURE :
-
Oral
-
SPECIES OBSERVED :
-
Rodent - rat
-
DOSE/DURATION :
-
1456 mg/kg/2Y-C
-
TOXIC EFFECTS :
-
Tumorigenic - Carcinogenic by RTECS criteria Reproductive - Tumorigenic effects - testicular tumors
-
TYPE OF TEST :
-
TDLo - Lowest published toxic dose
-
ROUTE OF EXPOSURE :
-
Intraperitoneal
-
SPECIES OBSERVED :
-
Rodent - mouse
-
DOSE/DURATION :
-
24 mg/kg/8W-I
-
TOXIC EFFECTS :
-
Tumorigenic - neoplastic by RTECS criteria Lungs, Thorax, or Respiration - tumors
-
TYPE OF TEST :
-
TDLo - Lowest published toxic dose
-
ROUTE OF EXPOSURE :
-
Oral
-
SPECIES OBSERVED :
-
Rodent - mouse
-
DOSE/DURATION :
-
300 mg/kg/2W-I
-
TOXIC EFFECTS :
-
Tumorigenic - Carcinogenic by RTECS criteria Lungs, Thorax, or Respiration - tumors Skin and Appendages - tumors
-
TYPE OF TEST :
-
TD - Toxic dose (other than lowest)
-
ROUTE OF EXPOSURE :
-
Intraperitoneal
-
SPECIES OBSERVED :
-
Rodent - mouse
-
DOSE/DURATION :
-
72 mg/kg/8W-I
-
TOXIC EFFECTS :
-
Tumorigenic - neoplastic by RTECS criteria Lungs, Thorax, or Respiration - tumors
-
TYPE OF TEST :
-
TD - Toxic dose (other than lowest)
-
ROUTE OF EXPOSURE :
-
Oral
-
SPECIES OBSERVED :
-
Rodent - rat
-
DOSE/DURATION :
-
1456 mg/kg/2Y-C
-
TOXIC EFFECTS :
-
Tumorigenic - Carcinogenic by RTECS criteria Reproductive - Tumorigenic effects - uterine tumors
-
TYPE OF TEST :
-
TDLo - Lowest published toxic dose
-
ROUTE OF EXPOSURE :
-
Oral
-
DOSE :
-
200 mg/kg
-
SEX/DURATION :
-
female 7-16 day(s) after conception
-
TOXIC EFFECTS :
-
Reproductive - Effects on Newborn - biochemical and metabolic
-
TYPE OF TEST :
-
TDLo - Lowest published toxic dose
-
ROUTE OF EXPOSURE :
-
Oral
-
DOSE :
-
560 mg/kg
-
SEX/DURATION :
-
female 6-21 day(s) after conception lactating female 10 day(s) post-birth
-
TOXIC EFFECTS :
-
Reproductive - Maternal Effects - parturition Reproductive - Effects on Newborn - stillbirth Reproductive - Effects on Newborn - viability index (e.g., # alive at day 4 per # born alive)
-
TYPE OF TEST :
-
TDLo - Lowest published toxic dose
-
ROUTE OF EXPOSURE :
-
Oral
-
DOSE :
-
75 mg/kg
-
SEX/DURATION :
-
male 5 day(s) pre-mating
-
TOXIC EFFECTS :
-
Reproductive - Fertility - male fertility index (e.g. # males impregnating females per # males exposed to fertile nonpregnant females)
-
TYPE OF TEST :
-
TDLo - Lowest published toxic dose
-
ROUTE OF EXPOSURE :
-
Oral
-
DOSE :
-
140 mg/kg
-
SEX/DURATION :
-
female 2 week(s) pre-mating - 3 week(s) post-birth
-
TOXIC EFFECTS :
-
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)
-
TYPE OF TEST :
-
TDLo - Lowest published toxic dose
-
ROUTE OF EXPOSURE :
-
Oral
-
DOSE :
-
150 mg/kg
-
SEX/DURATION :
-
male 5 day(s) pre-mating
-
TOXIC EFFECTS :
-
Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea) Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)
-
TYPE OF TEST :
-
TDLo - Lowest published toxic dose
-
ROUTE OF EXPOSURE :
-
Intraperitoneal
-
DOSE :
-
350 mg/kg
-
SEX/DURATION :
-
male 7 day(s) pre-mating
-
TOXIC EFFECTS :
-
Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count)
-
TYPE OF TEST :
-
TDLo - Lowest published toxic dose
-
ROUTE OF EXPOSURE :
-
Intraperitoneal
-
DOSE :
-
400 mg/kg
-
SEX/DURATION :
-
male 8 day(s) pre-mating
-
TOXIC EFFECTS :
-
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Effects on Newborn - behavioral
-
TYPE OF TEST :
-
TDLo - Lowest published toxic dose
-
ROUTE OF EXPOSURE :
-
Oral
-
DOSE :
-
571 mg/kg
-
SEX/DURATION :
-
male 16 day(s) pre-mating
-
TOXIC EFFECTS :
-
Reproductive - Paternal Effects - testes, epididymis, sperm duct
-
TYPE OF TEST :
-
TDLo - Lowest published toxic dose
-
ROUTE OF EXPOSURE :
-
Oral
-
DOSE :
-
95 gm/kg
-
SEX/DURATION :
-
male 4 week(s) pre-mating
-
TOXIC EFFECTS :
-
Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count) Reproductive - Fertility - male fertility index (e.g. # males impregnating females per # males exposed to fertile nonpregnant females) Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)
-
TYPE OF TEST :
-
TDLo - Lowest published toxic dose
-
ROUTE OF EXPOSURE :
-
Oral
-
DOSE :
-
95 gm/kg
-
SEX/DURATION :
-
female 4 week(s) pre-mating
-
TOXIC EFFECTS :
-
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)
-
TYPE OF TEST :
-
TDLo - Lowest published toxic dose
-
ROUTE OF EXPOSURE :
-
Oral
-
DOSE :
-
71 gm/kg
-
SEX/DURATION :
-
male 4 week(s) pre-mating
-
TOXIC EFFECTS :
-
Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth)
-
TYPE OF TEST :
-
TDLo - Lowest published toxic dose
-
ROUTE OF EXPOSURE :
-
Intraperitoneal
-
DOSE :
-
225 mg/kg
-
SEX/DURATION :
-
female 10-12 day(s) after conception
-
TOXIC EFFECTS :
-
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - musculoskeletal system
-
TYPE OF TEST :
-
TDLo - Lowest published toxic dose
-
ROUTE OF EXPOSURE :
-
Intraperitoneal
-
DOSE :
-
125 mg/kg
-
SEX/DURATION :
-
female 1 day(s) after conception
-
TOXIC EFFECTS :
-
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
-
TYPE OF TEST :
-
TDLo - Lowest published toxic dose
-
ROUTE OF EXPOSURE :
-
Intraperitoneal
-
DOSE :
-
250 mg/kg
-
SEX/DURATION :
-
male 5 day(s) pre-mating
-
TOXIC EFFECTS :
-
Reproductive - Fertility - male fertility index (e.g. # males impregnating females per # males exposed to fertile nonpregnant females) Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea) Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)
-
TYPE OF TEST :
-
TDLo - Lowest published toxic dose
-
ROUTE OF EXPOSURE :
-
Intraperitoneal
-
DOSE :
-
300 mg/kg
-
SEX/DURATION :
-
female 8-10 day(s) after conception
-
TOXIC EFFECTS :
-
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
-
TYPE OF TEST :
-
TDLo - Lowest published toxic dose
-
ROUTE OF EXPOSURE :
-
Intraperitoneal
-
DOSE :
-
75 mg/kg
-
SEX/DURATION :
-
female 12 day(s) after conception
-
TOXIC EFFECTS :
-
Reproductive - Specific Developmental Abnormalities - musculoskeletal system
-
TYPE OF TEST :
-
TDLo - Lowest published toxic dose
-
ROUTE OF EXPOSURE :
-
Intraperitoneal
-
DOSE :
-
225 mg/kg
-
SEX/DURATION :
-
female 10-12 day(s) after conception
-
TOXIC EFFECTS :
-
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Effects on Embryo or Fetus - fetal death
-
TYPE OF TEST :
-
Specific locus test
-
TYPE OF TEST :
-
Micronucleus test
-
TYPE OF TEST :
-
Unscheduled DNA synthesis
-
TYPE OF TEST :
-
Sister chromatid exchange
-
TYPE OF TEST :
-
Dominant lethal test
-
TYPE OF TEST :
-
Micronucleus test
-
TYPE OF TEST :
-
Specific locus test
-
TYPE OF TEST :
-
DNA damage
-
TYPE OF TEST :
-
Unscheduled DNA synthesis
-
TYPE OF TEST :
-
Cytogenetic analysis
-
TYPE OF TEST :
-
Cytogenetic analysis
-
TYPE OF TEST :
-
Sister chromatid exchange
-
TYPE OF TEST :
-
Sex chromosome loss and nondisjunction
-
TYPE OF TEST :
-
Dominant lethal test
-
TYPE OF TEST :
-
Dominant lethal test
-
TYPE OF TEST :
-
Sperm Morphology
-
TYPE OF TEST :
-
Sperm Morphology
-
TYPE OF TEST :
-
Heritable translocation test
MUTATION DATA
-
TYPE OF TEST :
-
Sex chromosome loss and nondisjunction
-
TEST SYSTEM :
-
Rodent - hamster Lung
-
REFERENCE :
-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 245,191,1990 *** REVIEWS *** ACGIH TLV-Animal carcinogen DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 ACGIH TLV-TWA 0.03 mg/m3 (skin) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 IARC Cancer Review:Animal Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 39,41,1986 IARC Cancer Review:Animal Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 60,389,1994 IARC Cancer Review:Human No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 39,41,1986 IARC Cancer Review:Human Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 60,389,1994 IARC Cancer Review:Group 2A IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 60,389,1994 TOXICOLOGY REVIEW EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972- Volume(issue)/page/year: 11,129,1975 TOXICOLOGY REVIEW CRTXB2 CRC Critical Reviews in Toxicology. (CRC Press, Inc., 2000 Corporate Blvd., NW, Boca Raton, FL 33431) V.1- 1971- Volume(issue)/page/year: 2,365,1973 TOXICOLOGY REVIEW CMTVAS Cahiers de Medecine du Travail. (Association Professionnelle Belge des Medecine du Travail, rue du Bultia, 6280 Gerpinnes, Belgium) V.1- 1963- Volume(issue)/page/year: 10(3),49,1973 TOXICOLOGY REVIEW CJNSA2 Canadian Journal of Neurological Sciences. (Faculty of Medicine, 2500 University Dr., Calgary, Alberta, Canada) V.1- 1974- Volume(issue)/page/year: 1,143,1974 TOXICOLOGY REVIEW CJNSA2 Canadian Journal of Neurological Sciences. (Faculty of Medicine, 2500 University Dr., Calgary, Alberta, Canada) V.1- 1974- Volume(issue)/page/year: 1,152,1974 TOXICOLOGY REVIEW NTOTDY Neurobehavioral Toxicology and Teratology. (Fayetteville, NY) V.3-8, 1981-86. For publisher information, see NETEEC. Volume(issue)/page/year: 3,445,1981 *** U.S. STANDARDS AND REGULATIONS *** MSHA STANDARD-air:TWA 0.3 mg/m3 (skin) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,5,1971 OSHA PEL (Gen Indu):8H TWA 0.3 mg/m3 (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Construc):8H TWA 0.3 mg/m3 (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):8H TWA 0.3 mg/m3 (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 OSHA PEL (Fed Cont):8H TWA 0.3 mg/m3 (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 41,50-204.50,1994 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-AUSTRALIA:TWA 0.3 mg/m3;Skin;Carcinogen JAN 1993 OEL-BELGIUM:TWA 0.3 mg/m3;Skin;Carcinogen JAN 1993 OEL-DENMARK:TWA 0.3 mg/m3;Skin;Carcinogen JAN 1993 OEL-FINLAND:TWA 0.3 mg/m3;STEL 0.9 mg/m3 JAN 1993 OEL-FRANCE:TWA 0.3 mg/m3 JAN 1993 OEL-GERMANY;Skin;Carcinogen JAN 1993 OEL-HUNGARY:STEL 0.3 mg/m3;Skin;Carcinogen JAN 1993 OEL-JAPAN:TWA 0.3 mg/m3;Skin JAN 1993 OEL-THE NETHERLANDS:TWA 0.3 mg/m3 JAN 1993 OEL-THE PHILIPPINES:TWA 0.3 mg/m3;Skin JAN 1993 OEL-RUSSIA:STEL 0.2 mg/m3;Skin JAN 1993 OEL-SWEDEN:TWA 0.3 mg/m3;STEL 0.9 mg/m3;Skin JAN 1993 OEL-SWITZERLAND:TWA 0.3 mg/m3;Skin;Carcinogen JAN 1993 OEL-UNITED KINGDOM:TWA 0.3 mg/m3;STEL 0.6 mg/m3;Skin JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO ACRYLAMIDE-air:10H CA TWA 0.03 mg/m3 (Sk) REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 03540 No. of Facilities: 442 (estimated) No. of Industries: 10 No. of Occupations: 24 No. of Employees: 7047 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 03540 No. of Facilities: 453 (estimated) No. of Industries: 19 No. of Occupations: 22 No. of Employees: 10651 (estimated) No. of Female Employees: 721 (estimated)
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