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7789-77-7生产厂家

7789-77-7价格

7789-77-7

7789-77-7结构式
7789-77-7结构式
  • 常用中文名:磷酸氢钙
  • 常用英文名:Dicalcium phosphate dihydrate
  • CAS号:7789-77-7
  • 分子式:CaH5O6P
  • 分子量:172.09
  • 相关类别: 无机化工 无机盐 磷化物、金属的磷酸、偏磷酸、次磷酸和焦磷酸盐
  • 发布时间:2018-08-15 22:45:04
  • 更新时间:2024-01-02 17:57:57
  • 二水合磷酸氢钙,也称为CHPD或DCPD。二水合磷酸氢钙在泌尿系结石中很常见。磷酸氢钙二水合物可用作赋形剂,如稀释剂、吸附剂。药用辅料,或称药用辅料,是指除药物成分外,在制药过程中使用的其他化学物质。药用辅料一般是指药物制剂中的非活性成分,可以提高药物制剂的稳定性、溶解性和加工性。药用辅料也会影响联合给药药物的吸收、分布、代谢和消除(ADME)过程[1][2]。

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中文名 磷酸氢钙
英文名 calcium hydrogenphosphate dihydrate
中文别名 磷酸氢钙二水合物
二水合磷酸氢钙
英文别名 calcium monohydrogen phosphate
acid calcium monophosphate
calcium hydrogen phosphate dihydrate
dicalciurn phosphate
dicalcium phosphate
calcium monohydrogen phosphate dihydrate
BicalciuM phosphate
Di-tab
Calcium hydrogenphosphate dihydrate
Calciumhydrogenphosphate,dih
MFCD00149621
Calcium phosphate di
Dibasic calcium phosphate dihydrate
Calcium hydrogen phosphate hydrate (1:1:2)
dibasic calcium phosphate
EINECS 231-826-1
Calcium phosphate, dibasic, dihydrate
Bekapress D 2
DICALCIUM PHOSPHAT
hydrogen calcium orthophosphate
CALCIUM PHOSPH
dicalcium phosphate anhydrous
phosphoric acid calcium salt
描述 二水合磷酸氢钙,也称为CHPD或DCPD。二水合磷酸氢钙在泌尿系结石中很常见。磷酸氢钙二水合物可用作赋形剂,如稀释剂、吸附剂。药用辅料,或称药用辅料,是指除药物成分外,在制药过程中使用的其他化学物质。药用辅料一般是指药物制剂中的非活性成分,可以提高药物制剂的稳定性、溶解性和加工性。药用辅料也会影响联合给药药物的吸收、分布、代谢和消除(ADME)过程[1][2]。
相关类别
参考文献

[1]. Madhurambal G, et al. Crystallization and thermal characterization of calcium hydrogen phosphate dihydrate crystals[J]. Journal of thermal analysis and calorimetry, 2009, 96(1): 73-76.

[2]. Elder DP, et al. Pharmaceutical excipients - quality, regulatory and biopharmaceutical considerations. Eur J Pharm Sci. 2016 May 25;87:88-99.  

密度 2.31
沸点 158ºC at 760 mmHg
熔点 109°C -H₂O
分子式 CaH5O6P
分子量 172.09
精确质量 171.944962
PSA 111.69000
外观性状 白色结晶固体
折射率 1.5394
储存条件

1.食品级塑料袋外套编织袋包装。

2.应贮存在通风、干燥、阴凉、清洁的库房内。包装要密封,防潮。不得与有毒物品和其他污染物品共贮混运。运输时要防雨淋和烈日暴晒。装卸时要小心轻放,防止包装破损。失火时,可用水、沙土、各种灭火器进行扑救。

稳定性

有二水磷酸氢钙和无水磷酸氢钙两种。在低于36℃时,二水物是稳定的;高于36℃时,无水物是稳定的。常用的为二水物CaHPO4·2H2O,其相对密度为2.306,微溶于水,不溶于乙醇,易溶于稀盐酸、硝酸、醋酸,在空气中稳定,加热至100℃以上,逐渐失去结晶水,加热至175℃以上转化为CaHPO4,在400~430℃时,失去结晶水而成焦磷酸钙Ca2P2O7。结晶水即使在100℃以下,也会慢慢失去。

水溶解性 每100毫升水中的溶解克数: 4.303×10-3/20℃
计算化学

1.疏水参数计算参考值(XlogP):无

2.氢键供体数量:3

3.氢键受体数量:6

4.可旋转化学键数量:0

5.互变异构体数量:无

6.拓扑分子极性表面积85.4

7.重原子数量:8

8.表面电荷:0

9.复杂度:46.5

10.同位素原子数量:0

11.确定原子立构中心数量:0

12.不确定原子立构中心数量:0

13.确定化学键立构中心数量:0

14.不确定化学键立构中心数量:0

15.共价键单元数量:4

更多

1. 性状:白色单斜晶系结晶性粉末。无臭、无味。

2. 密度(g/mL 25ºC):2.306

3. 熔点(ºC):190

4. 溶解性:易缓慢地溶于甘油,微溶于水,不溶于乙醇,易溶于稀盐酸和硝酸。


Section1. IDENTIFICATION OF THE SUBSTANCE/MIXTURE
Product identifiers
Product name: Calcium phosphate dibasic dihydrate
CAS-No.: 7789-77-7


Section2. HAZARDS IDENTIFICATION
Classification of the substance or mixture
Classification according to Regulation (EC) No 1272/2008 [EU-GHS/CLP]
Skin irritation (Category 2)
Eye irritation (Category 2)
Specific target organ toxicity - single exposure (Category 3)
Classification according to EU Directives 67/548/EEC or 1999/45/EC
Irritating to eyes, respiratory system and skin.
Label elements
Labelling according Regulation (EC) No 1272/2008 [CLP]
Pictogram
Signal wordWarning
Hazard statement(s)
Causes skin irritation.
Causes serious eye irritation.
May cause respiratory irritation.
Precautionary statement(s)
Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray.
P305 + P351 + P338IF IN EYES: Rinse cautiously with water for several minutes. Remove
contact lenses, if present and easy to do. Continue rinsing.
Supplemental Hazardnone
Statements
According to European Directive 67/548/EEC as amended.
Hazard symbol(s)
R-phrase(s)
R36/37/38Irritating to eyes, respiratory system and skin.
S-phrase(s)
S26In case of contact with eyes, rinse immediately with plenty of water and
seek medical advice.
S36Wear suitable protective clothing.
Other hazards - none

Section3. COMPOSITION/INFORMATION ON INGREDIENTS
Substances
Formula: HCaO4P · 2H2O
Molecular Weight: 172,09 g/mol
ComponentConcentration
Calcium hydrogenorthophosphate dihydrate
CAS-No.7789-77-7-
EC-No.231-826-1

Section4. FIRST AID MEASURES
Description of first aid measures
General advice
Consult a physician. Show this safety data sheet to the doctor in attendance.
If inhaled
If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician.
In case of skin contact
Wash off with soap and plenty of water. Consult a physician.
In case of eye contact
Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.
If swallowed
Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.
Most important symptoms and effects, both acute and delayed
Indication of any immediate medical attention and special treatment needed
no data available

Section5. FIREFIGHTING MEASURES
Extinguishing media
Suitable extinguishing media
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
Special hazards arising from the substance or mixture
Thermal decomposition may produce toxic fumes of phosphorus oxides and/or phosphine
Oxides of phosphorus, Calcium oxide
Advice for firefighters
Wear self contained breathing apparatus for fire fighting if necessary.
Further information
no data available

Section6. ACCIDENTAL RELEASE MEASURES
Personal precautions, protective equipment and emergency procedures
Use personal protective equipment. Avoid dust formation. Avoid breathing vapors, mist or gas. Ensure
adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust.
Environmental precautions
Do not let product enter drains.
Methods and materials for containment and cleaning up
Pick up and arrange disposal without creating dust. Sweep up and shovel. Keep in suitable, closed
containers for disposal.
Reference to other sections
For disposal see section 13.

Section7. HANDLING AND STORAGE
Precautions for safe handling
Avoid contact with skin and eyes. Avoid formation of dust and aerosols.
Provide appropriate exhaust ventilation at places where dust is formed.Normal measures for preventive fire
protection.
Conditions for safe storage, including any incompatibilities
Store in cool place. Keep container tightly closed in a dry and well-ventilated place.
Specific end uses
no data available

Section8. EXPOSURE CONTROLS/PERSONAL PROTECTION
Control parameters
Components with workplace control parameters
Exposure controls
Appropriate engineering controls
Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and
at the end of workday.
Personal protective equipment
Eye/face protection
Safety glasses with side-shields conforming to EN166 Use equipment for eye protection tested
and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).
Skin protection
Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique
(without touching glove's outer surface) to avoid skin contact with this product. Dispose of
contaminated gloves after use in accordance with applicable laws and good laboratory practices.
Wash and dry hands.
The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and
the standard EN 374 derived from it.
Body Protection
impervious clothing, The type of protective equipment must be selected according to the
concentration and amount of the dangerous substance at the specific workplace.
Respiratory protection
For nuisance exposures use type P95 (US) or type P1 (EU EN 143) particle respirator.For higher
level protection use type OV/AG/P99 (US) or type ABEK-P2 (EU EN 143) respirator cartridges.
Use respirators and components tested and approved under appropriate government standards
such as NIOSH (US) or CEN (EU).

Section9. PHYSICAL AND CHEMICAL PROPERTIES
Information on basic physical and chemical properties
a) AppearanceForm: crystalline
Colour: white
b) Odourno data available
c) Odour Thresholdno data available
d) pHno data available
e) Melting point/freezingno data available
point
f) Initial boiling point and no data available
boiling range
g) Flash pointno data available
h) Evaporation rateno data available
i) Flammability (solid, gas) no data available
j) Upper/lowerno data available
flammability or
explosive limits
k) Vapour pressureno data available
l) Vapour densityno data available
m) Relative density2,310 g/cm3
n) Water solubilityno data available
o) Partition coefficient: n- no data available
octanol/water
p) Autoignitionno data available
temperature
q) Decompositionno data available
temperature
r) Viscosityno data available
s) Explosive propertiesno data available
t) Oxidizing propertiesno data available
Other safety information
no data available

Section10. STABILITY AND REACTIVITY
Reactivity
no data available
Chemical stability
no data available
Possibility of hazardous reactions
no data available
Conditions to avoid
no data available
Incompatible materials
Strong oxidizing agents
Hazardous decomposition products
Other decomposition products - no data available

Section11. TOXICOLOGICAL INFORMATION
Information on toxicological effects
Acute toxicity
no data available
Skin corrosion/irritation
no data available
Serious eye damage/eye irritation
no data available
Respiratory or skin sensitization
no data available
Germ cell mutagenicity
no data available
Carcinogenicity
IARC:No component of this product present at levels greater than or equal to 0.1% is identified as
probable, possible or confirmed human carcinogen by IARC.
Reproductive toxicity
no data available
Specific target organ toxicity - single exposure
Inhalation - May cause respiratory irritation.
Specific target organ toxicity - repeated exposure
no data available
Aspiration hazard
no data available
Potential health effects
InhalationMay be harmful if inhaled. Causes respiratory tract irritation.
IngestionMay be harmful if swallowed.
SkinMay be harmful if absorbed through skin. Causes skin irritation.
EyesCauses serious eye irritation.
Additional Information
RTECS: Not available

Section12. ECOLOGICAL INFORMATION
Toxicity
no data available
Persistence and degradability
no data available
Bioaccumulative potential
no data available
Mobility in soil
no data available
Results of PBT and vPvB assessment
no data available
Other adverse effects
no data available

Section13. DISPOSAL CONSIDERATIONS
Waste treatment methods
Product
Offer surplus and non-recyclable solutions to a licensed disposal company. Contact a licensed
professional waste disposal service to dispose of this material. Dissolve or mix the material with a
combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber.
Contaminated packaging
Dispose of as unused product.

Section14. TRANSPORT INFORMATION
UN number
ADR/RID: -IMDG: -IATA: -
UN proper shipping name
ADR/RID: Not dangerous goods
IMDG: Not dangerous goods
IATA:Not dangerous goods
Transport hazard class(es)
ADR/RID: -IMDG: -IATA: -
Packaging group
ADR/RID: -IMDG: -IATA: -
Environmental hazards
ADR/RID: noIMDG Marine pollutant: noIATA: no
Special precautions for user
no data available

Section15. REGULATORY INFORMATION
This safety datasheet complies with the requirements of Regulation (EC) No. 1907/2006.
Safety, health and environmental regulations/legislation specific for the substance or mixture
no data available
Chemical Safety Assessment


SECTION 16 - ADDITIONAL INFORMATION
N/A

毒理学数据:

急性毒性:LD50:4000mg/Kg(大鼠经口);4720mg/Kg(兔经皮)。

LC50:9400mg/m3,2小时(小鼠吸入)。

刺激口、鼻、喉和肺,导致味觉、嗅觉衰减,鼻孔出血。

生态学数据:

对水是稍微危害的,若无政府许可,勿将材料排入周围环境。

危害码 (欧洲) Xi:Irritant
风险声明 (欧洲) R36/37/38
安全声明 (欧洲) S26-S36
危险品运输编码 NONH for all modes of transport
WGK德国 1

~%

7789-77-7结构式

7789-77-7

文献:Journal of Alloys and Compounds, , vol. 394, # 1-2 p. 13 - 18

1.用盐酸或硫酸分解兽骨,再加氢氧化钙,在一定的pH值下沉淀,可得磷酸氢钙,再经过滤、洗涤、干燥可制得成品。

7789-77-7 preparation

2.以普通过磷酸钙为原料,经多段水萃取、脱氟、石灰乳中和制得。也可由硫酸萃取磷酸经计量后进入脱氟槽,加入脱氟剂脱除氟、砷、铅等过程制得。或者将过磷酸钙粉碎后送入煅烧炉中,在890~1300℃下煅烧,脱氟、脱硫后出料,冷却、粉碎制得。

3.采用磷酸和石灰乳中和法或者磷酸钠盐与氯化钙的复分解反应,反应过程中要注意溶液pH的变化,直至反应终点。生成物溶液经清水洗涤、离心脱水、干燥、粉碎后得成品。

4.将二水合磷酸氢二钠90g(0.5mol)与磷酸二氢钾5g(0.037mol)溶于1L的热水中,将溶液冷却至室温。另外,将六水合氯化钙110g(0.5mol)溶于1L的水中制成溶液。向10g磷酸二氢钾溶于0.5L水所形成的溶液中,将上述两种溶液通过滴液漏斗以同样的速度慢慢滴加,并进行充分搅拌。反应液的pH值最初为4,加入甲基红为指示剂,使其保持pH值为4~5。如果pH值升高,则用磷酸二氢钾溶液调整pH值,以便使其产生沉淀。滴加过程约需2.5至3h。然后,将结晶过滤分离,用330mL磷酸溶液(在1L水中含有45%磷酸0.16mL)洗涤3次,然后用250mL乙醇洗涤,在空气中干燥就可制得二水合物。洗涤操作应快速不间断进行,在20min以内完成。直到洗液的pH值达到5时。

7789-77-7 preparation