56-72-4

56-72-4结构式

常用中文名：蝇毒磷
常用英文名：Coumaphos
CAS号：56-72-4
分子式：C₁₄H₁₆ClO₅PS
分子量：362.766
相关类别：化学农药原药杀虫剂有机磷杀虫剂
发布时间：2018-07-14 16:29:03
更新时间：2024-01-08 14:05:28
Coumaphos is aorganothiophosphorus cholinesterase inhibitor that is used as an anthelmintic, insecticide, and as a nematocide.

中文名	蝇毒磷
英文名	coumaphos
中文别名	香豆磷 O,O-二乙基-O-(3氯-4-甲基香豆素-7)-硫代磷酸酯 O,O-二乙基-O-(3-氯-4甲基香豆素-7)硫逐磷酸酯库马磷蝇毒硫磷蝇毒
英文别名	Agridip Coumaphos Meldone Baymix Phosphorothioic acid, O- (3-chloro-4-methyl-2-oxo-2H-1-benzopyran-7-yl) O,O-diethyl ester 3-chloro-7-diethoxyphosphinothioyloxy-4-methylcoumarin Asuntol 3-Chlor-7-diaethoxythiophosphoryloxy-4-methyl-cumarin Meldane Azunthol Phosphorothioic acid, O-(3-chloro-4-methyl-2-oxo-2H-1-benzopyran-7-yl) O,O-diethyl ester 3-chloro-7-diethoxythiophosphoryloxy-4-methyl-coumarin EINECS 200-285-3 Coumaphos [BAN] O-(3-Chlor-4-methyl-2-oxo-2H-chromen-7-yl)-O,O-diethylthiophosphat O-(3-chloro-4-methyl-2-oxo-2H-1-benzopyran-7-yl) O,O-diethyl phosphorothioate Muscatox Thiophosphate de O-(3-chloro-4-méthyl-2-oxo-2H-chromén-7-yle) et de O,O-diéthyle O-(3-chloro-4-methyl-2-oxo-2H-chromen-7-yl) O,O-diethylphosphorothioate 3-chloro-7-diethoxyphosphinothioyloxy-4-methylchromen-2-one O-3-chloro-4-methyl-2-oxo-2H-chromen-7-yl O,O-diethyl phosphorothioate O-(3-Chloro-4-methyl-2-oxo-2H-chromen-7-yl) O,O-diethyl phosphorothioate Asunthol Coumafos MFCD00041820

密度	1.4±0.1 g/cm3
沸点	449.9±55.0 °C at 760 mmHg
熔点	91ºC
分子式	C₁₄H₁₆ClO₅PS
分子量	362.766
闪点	225.9±31.5 °C
精确质量	362.014465
PSA	99.80000
LogP	3.86
外观性状	黄褐色或米色固体
蒸汽压	0.0±1.1 mmHg at 25°C
折射率	1.578
储存条件	本品应密封保存。
稳定性	Stable. Combustible. Incompatible with alkalies, strong oxidising agents.
分子结构	1、摩尔折射率：86.84 2、摩尔体积（m³/mol）：261.8 3、等张比容（90.2K）：709.5 4、表面张力（dyne/cm）：53.9 5、极化率（10 ^-24cm ³）：34.42
计算化学	1.疏水参数计算参考值（XlogP）:4.5 2.氢键供体数量:0 3.氢键受体数量:6 4.可旋转化学键数量:6 5.互变异构体数量:无 6.拓扑分子极性表面积86.1 7.重原子数量:22 8.表面电荷:0 9.复杂度:500 10.同位素原子数量:0 11.确定原子立构中心数量:0 12.不确定原子立构中心数量:0 13.确定化学键立构中心数量:0 14.不确定化学键立构中心数量:0 15.共价键单元数量:1
更多	1. 性状：无色结晶。工业为棕色结晶 2. 密度（g/mL,25/4℃）： 1.474 3. 相对蒸汽密度（g/mL,空气=1）：未确定 4. 熔点（ºC）：95℃ 5. 沸点（ºC,常压）：未确定 6. 沸点（ºC,5.2kPa）：未确定 7. 折射率：未确定 8. 闪点（ºC）：未确定 9. 比旋光度（º）：未确定 10. 自燃点或引燃温度（ºC）：未确定 11. 蒸气压（kPa,25ºC）：未确定 12. 饱和蒸气压（kPa,60ºC）：未确定 13. 燃烧热（KJ/mol）：未确定 14. 临界温度（ºC）：未确定 15. 临界压力（KPa）：未确定 16. 油水（辛醇/水）分配系数的对数值：未确定 17. 爆炸上限（%,V/V）：未确定 18. 爆炸下限（%,V/V）：未确定 19. 溶解性：微溶于水

国标编号:	61125
ＣＡＳ:	56-72-4
中文名称:	蝇毒磷
英文名称:	Coumaphos；Asunthol
别名:	蝇毒硫磷；O，O-二乙基-O-(3-氯-4-甲基香豆素-7)硫逐磷酸酯
分子式:	C₁₄H₁₆ClO₅PS
分子量:	362.78
熔点:	95℃
密度:	相对密度(水=1)1.474(
蒸汽压:	20℃
溶解性:	微溶于水
稳定性:	稳定
外观与性状:	无色结晶。工业为棕色结晶
危险标记:	14(有毒品)
用途:	用作畜用杀虫剂

2.对环境的影响:
一、健康危害

侵入途径：吸入、食入、经皮吸收。
健康危害：本品为高毒有机磷杀虫剂。能使全血胆碱酯酶活性下降，引起头痛、头晕、无外国籍、烦燥、恶心、呕吐、出汗、流涎、瞳孔缩小、抽搐、呼吸困难、紫绀，重者常伴有肺水肿、脑水肿，可死于呼吸衰竭。

二、毒理学资料及环境行为

毒性：对人畜高毒。
急性毒性：LD5013mg/kg(大鼠经口)；28mg/kg(小鼠经口)；860mg/kg(大鼠经皮)

危险特性：遇明火、高热可燃。受高热分解，放出高毒的烟气。
燃烧(分解)产物：一氧公碳、二氧化碳、氯化氢、氧化硫、氧化磷。

3.现场应急监测方法:
　

4.实验室监测方法:
气相色谱法《固体废弃物试验分析评价手册》中国环境监测总站等译

5.环境标准:
前苏联(1975) 水体中有害有机物的最大允许浓度 1.0mg/L
联合国规划署(1974)保护水生生物淡水中农药的最大允许浓度 0.001μg/L

6.应急处理处置方法:
一、泄漏应急处理

隔离泄漏污染区，周围设警告标志，建议应急处理珍员戴自给式呼吸器，穿化学防护服。不要直接接触泄漏物，避免扬尘，收集于干燥净洁有盖的容器中，倒至空旷地方深埋。也可以用大量水冲洗，经稀释的洗水放入废水系统。如大量泄漏，收集回收或无处理后废弃。

二、防护措施

呼吸系统防护：生产操作或农业使用时，佩戴防毒口罩。紧急事态抢救或逃生时，应该佩戴自给式呼吸器。
眼睛防护：戴化学安全防护眼镜。
防护服：穿相应的防护服。
手防护：戴防化学品手套。
其它：工作现场禁止吸烟、进食和饮水。工作后，淋浴更衣。工作服不要带到非作业场所，单独存放被毒物污染的衣服，洗后再用。注意个人清洁卫生。

三、急救措施

皮肤接触：用肥皂水及清水彻底冲洗。就医。
眼睛接触：拉开眼睑，用流动清水冲洗15分钟。就医。
吸入：脱离现场至空气新鲜处。呼吸困难时给输氧。呼吸停止时，立即进行人工呼吸。
食入：误服者，饮适量温水，催吐。洗胃。就医。合并使用阿托品及复能剂(氯磷定、解磷定)。

灭火方法：泡沫、干粉、砂土、二氧化碳。

CHEMICAL IDENTIFICATION

RTECS NUMBER :: GN6300000

CHEMICAL NAME :: Coumarin, 3-chloro-7-hydroxy-4-methyl-, O-ester with O,O-diethyl phosphorothioate

CAS REGISTRY NUMBER :: 56-72-4

BEILSTEIN REFERENCE NO. :: 0327083

LAST UPDATED :: 199701

DATA ITEMS CITED :: 28

MOLECULAR FORMULA :: C14-H16-Cl-O5-P-S

MOLECULAR WEIGHT :: 362.78

WISWESSER LINE NOTATION :: T66 BOVJ DG E1 IOPS&O2&O2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 13 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 303 mg/m3

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 860 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 7500 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 28 mg/kg

TOXIC EFFECTS :: Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 50 mg/kg

TOXIC EFFECTS :: Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 80 mg/kg

TOXIC EFFECTS :: Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 2600 ug/kg

TOXIC EFFECTS :: Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 58 mg/kg

TOXIC EFFECTS :: Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 140 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - pigeon

DOSE/DURATION :: 5620 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - quail

DOSE/DURATION :: 13300 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - duck

DOSE/DURATION :: 29800 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - domestic

DOSE/DURATION :: 22600 ug/kg

TOXIC EFFECTS :: Behavioral - ataxia Gastrointestinal - hypermotility, diarrhea Gastrointestinal - other changes

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Mammal - species unspecified

DOSE/DURATION :: 55 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - wild bird species

DOSE/DURATION :: 1780 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Bird - wild bird species

DOSE/DURATION :: 7500 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 168 mg/kg/28W-I

TOXIC EFFECTS :: Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase

MUTATION DATA

TYPE OF TEST :: Morphological transformation

TEST SYSTEM :: Rodent - rat Embryo

DOSE/DURATION :: 1400 ng/plate

REFERENCE :: JJATDK JAT, Journal of Applied Toxicology. (John Wiley & Sons Ltd., Baffins Lane, Chichester, W. Sussex PO19 1UD, UK) V.1- 1981- Volume(issue)/page/year: 1,190,1981 *** REVIEWS *** TOXICOLOGY REVIEW AQMOAC Air Quality Monographs. (Washington, DC) No.69-1 - No.75-25, 1969-75(?). Discontinued. Volume(issue)/page/year: #73-19,1973 TOXICOLOGY REVIEW RREVAH Residue Reviews. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1962- Volume(issue)/page/year: 46,1,1973 TOXICOLOGY REVIEW PMDCAY Progress in Medical Chemistry. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.1- 1961- Volume(issue)/page/year: 10,85,1974 TOXICOLOGY REVIEW RREVAH Residue Reviews. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1962- Volume(issue)/page/year: 63,1,1976 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989

符号	GHS06, GHS09
信号词	Danger
危害声明	H300-H312-H410
警示性声明	P264-P273-P280-P301 + P310-P501
个人防护装备	Eyeshields;Faceshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
危害码 (欧洲)	T+: Very toxic;N: Dangerous for the environment;
风险声明 (欧洲)	R21;R28;R50/53
安全声明 (欧洲)	S28-S36/37-S45-S60-S61-S36-S26-S16
危险品运输编码	2783
RTECS号	GN6300000
包装等级	II
危险类别	6.1(a)

6174-86-3

2524-04-1

~58%

56-72-4

文献：Journal of Medicinal Chemistry, , vol. 49, # 1 p. 246 - 255

上游产品 2
6174-86-3 2524-04-1
下游产品 2
6174-86-3 2465-65-8

（1）200g乙酰乙酸乙酯及270g SO2CI2，分别溶于100ml苯中，然后在10℃时，将SO2CI2苯溶液滴入乙酰乙酸乙酯苯溶液中而得。（2）将间苯二酚88g和α-氯化乙酰乙酸乙酯132g滴加640ml浓硫酸中，温度在5℃以下进行反应而得3-氯-4-甲基-7-羟基香豆素。将44g 3-氯-4-甲基-7-羟基香豆素，29g无水碳酸钾同置於500ml甲乙酮中，在回流和搅拌下，滴加40g O,O-二乙基硫代磷酰氯，回流2h而得蝇毒磷。

56-72-4	321-54-0
7700-17-6	2778-04-3
919-54-0	299-84-3
3983-45-7	2763-96-4
4104-14-7	347884-61-1