12126-59-9

• 常用中文名：共轭雌激素
• 常用英文名：Premarin
• CAS号：12126-59-9
• 分子式：C₁₈H₁₉NaO₅S
• 分子量：370.395
• 相关类别： 原料药 激素及调节内分泌功能类药 雌激素及孕激素类药
• 发布时间：2018-05-02 08:00:00
• 更新时间：2024-01-31 00:33:24
• Estrogens, conjugated is a pharmaceutical preparation containing a mixture of water-soluble, conjugated estrogens derived wholly or in part from URINE of pregnant mares or synthetically from ESTRONE and EQUILIN. Conjugated estrogens are a medicine that contains a mixture of estrogen hormones. It is used to treat moderate to severe hot flashes, changes in and around the vagina, and other symptoms of menopause or low amounts of estrogen (hypoestrogenism). This medicine is also used to prevent osteoporosis (thinning of the bones) after menopause. Conjugated estrogens tablet is also used to treat symptoms of breast and prostate cancer that have spread through the body in men and women. It is also used to treat certain conditions in women before menopause if their ovaries do not make enough estrogen naturally.

名称

• 中文名: 共轭雌激素
• 英文名: Premarin
• 英文别名: MFCD00240712; Equilin sodium sulfate; Estra-1,3,5(10),7-tetraen-17-one, 3-(sulfooxy)-, sodium salt (1:1); Sodium 17-oxoestra-1,3,5(10),7-tetraen-3-yl sulfate; Sodium equilin sulfate; EINECS 235-199-5; Premarin

物化性质

• 分子式: C₁₈H₁₉NaO₅S
• 分子量: 370.395
• 精确质量: 370.085083
• PSA: 91.88000
• LogP: 3.95170

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : GL1224000 CHEMICAL NAME : Conjugated estrogenic hormones CAS REGISTRY NUMBER : 12126-59-9 LAST UPDATED : 199510 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human - woman DOSE/DURATION : 108 mg/kg/4Y-C TOXIC EFFECTS : Tumorigenic - Carcinogenic by RTECS criteria Vascular - tumors Liver - tumors REFERENCE : AIMDAP Archives of Internal Medicine. (AMA, 535 N. Dearborn St., Chicago, IL 60610) V.1- 1908- Volume(issue)/page/year: 137,357,1977 TYPE OF TEST : TD - Toxic dose (other than lowest) ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human - woman DOSE/DURATION : 27 mg/kg/3Y-C TOXIC EFFECTS : Tumorigenic - neoplastic by RTECS criteria Liver - tumors REFERENCE : NYSJAM New York State Journal of Medicine. (Medical Soc. of the State of New York, POB 5405, Lake Success, NY 11042) V.1- 1901- Volume(issue)/page/year: 78,1933,1978 ** REPRODUCTIVE DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Unreported DOSE : 3 mg/kg SEX/DURATION : female 1-5 day(s) after conception TOXIC EFFECTS : Reproductive - Fertility - female fertility index (e.g. # females pregnant per # sperm positive females; # females pregnant per # females mated) REFERENCE : JAMAAP JAMA, Journal of the American Medical Association. (AMA, 535 N. Dearborn St., Chicago, IL 60610) V.1- 1883- Volume(issue)/page/year: 244,1336,1980 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral DOSE : 4167 ug/kg SEX/DURATION : female 1-5 day(s) after conception TOXIC EFFECTS : Reproductive - Fertility - female fertility index (e.g. # females pregnant per # sperm positive females; # females pregnant per # females mated) REFERENCE : AJOGAH American Journal of Obstetrics and Gynecology. (C.V. Mosby Co., 11830 Westline Industrial Dr., St. Louis, MO 63146) V.1- 1920- Volume(issue)/page/year: 115,101,1973 *** REVIEWS *** IARC Cancer Review:Animal Limited Evidence IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,283,1987