985-16-0

• 常用中文名：萘夫西林钠
• 常用英文名：nafcillin sodium
• CAS号：985-16-0
• 分子式：C₂₁H₂₁N₂NaO₅S
• 分子量：436.45700
• 相关类别： 原料药 抗生素类药物 青霉素类药
• 发布时间：2018-04-09 08:00:00
• 更新时间：2026-07-17 03:48:11
• Nafcillin sodium 是第二代耐青霉素酶的青霉素类抗生素。Nafcillin sodium 可用于葡萄球菌感染的研究。

名称

• 中文名: 萘夫西林钠
• 英文名: nafcillin sodium
• 中文别名: 萘夫西林; 萘夫西林溶液, 100PPM; 纳夫西林钠盐; 氘6-萘夫西林钠盐; 奈夫西林钠盐; 乙氧萘青霉素
• 英文别名: Einecs -4; SodiuM 6-(2-(ethoxy-d5)-1-naphthaMido)-3,3-diMethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]htane-2-cboxylate; Wy 3277-d5; SodiuM Nafcillin-d5; 4-Thia-1-azabicyclo(3.2.0)htane-2-cboxylic acid, 6-(2-ethoxy-1-naphthamido)-3,3-dimethyl-7-oxo-, monosodium salt; NAFCILLIN; (2S,5R,6R)-6-[[(2-Ethoxy-1-naphthalenyl)carbonyl]amino]-3,3-diMethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]htane-2-cboxylic Acid SodiuM Salt; Nafcillin sodium sal; N-Ethyl-3-(trifluormethyl)-anilin; SodiuM 6-(2-(ethoxy-d5)-1-naphthaMido)penicillanate; brl1383; Nafcillin sodium; unipen; NAFCILLIN SODIUM SALT; 4-Thia-1-azabicyclo[3.2.0]htane-2-cboxylicacid, 6-[[(2-ethoxy-1-naphthalenyl)carbonyl]amino]-3,3-dimethyl-7-oxo-, sodiumsalt (1:1), (2S,5R,6R); Nafcil; D6-Nafcillin sodium salt; 4-Thia-1-azabicyclo3.2.0htane-2-cboxylic acid, 6-(2-ethoxy-1-naphthalenyl)cbonylamino-3,3-dimethyl-7-oxo-, monosodium salt, (2S,5R,6R); Naphthicillin-d5; SodiuM 6-(2-ethoxy-1-naphthaMido)-3,3-diMethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]htane-2-cboxylate; Naphthicillin; Benzenamine,N-ethyl-3-(trifluoromethyl); NAFCILLIN SODIUM ANHYDROUS; BRL 1383-d5; (2S,5R,6R)-6-[[(2-(Ethoxy-d5)-1-naphthalenyl)carbonyl]amino]-3,3-diMethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]htane-2-cboxylic Acid SodiuM Salt; sodium [2S-(2alpha,5alpha,6beta)]-6-[[(2-ethoxy-1-naphthyl)carbonyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]htane-2-cboxylate; (2S,5β)-6α-[(2-Ethoxy-1-naphthoyl)amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]htane-2β-cboxylic acid sodium salt; naftopen; 4-Thia-1-azabicyclo(3.2.0)htane-2-cboxylic acid, 6-(((2-ethoxy-1-naphthalenyl)carbonyl)amido)-3,3-dimethyl-7-oxo-, monosodium salt, (2S,5R,6R); NAFCILLIN SODIUM SALT //BP; 6-(2-(Ethoxy-d5)-1-naphthaMido)-3,3-diMethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]htane-2-cboxylic Acid SodiuM Salt; sodium6-(2-ethoxy-1-naphthamido)penicillanate; wy3277; Naftopen-d5; N-ethyl-3-trifluoromethyl-aniline; Nafcillin sodium salt solution,100ppm; 6-[2-ETHOXY-1-NAPHTHAMIDO]-PENICILLIN SODIUM SALT; sodiumnafcillin; 6-(2-(Ethoxy-d5)-1-naphthaMido)penicillin SodiuM Salt; 6-(2-Ethoxy-1-naphthaMido)-3,3-diMethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]htane-2-cboxylic Acid SodiuM Salt; Nafcil-d5; Sodium nafcillin; 6-(2-ethoxy-1-naphthamido)penicillinsodium; 3-dimethyl-7-oxo-monosodiumsalt

物化性质

• 密度: 1.42g/cm3
• 沸点: 714.1ºC at 760mmHg
• 分子式: C₂₁H₂₁N₂NaO₅S
• 分子量: 436.45700
• 闪点: 385.7ºC
• 精确质量: 436.10700
• PSA: 124.07000
• LogP: 1.47790
• 储存条件: Store at 0-5°C

生物活性

• 描述: Nafcillin sodium 是第二代耐青霉素酶的青霉素类抗生素。Nafcillin sodium 可用于葡萄球菌感染的研究。
• 相关类别:
  研究领域 >> 感染
• 参考文献:

  [1]. Tan AK, et, al. Identification of the site of covalent attachment of nafcillin, a reversible suicide inhibitor of beta-lactamase. Biochem J. 1992 Jan 1;281 ( Pt 1)(Pt 1):191-6.

  [2]. Palmer DL, et, al. Bacterial wound colonization after broad-spectrum versus narrow-spectrum antibiotics. Ann Thorac Surg. 1995 Mar;59(3):626-31.

  [3]. Monogue ML, et, al. Nafcillin versus cefazolin for the treatment of methicillin-susceptible Staphylococcus aureus bacteremia. J Infect Public Health. Sep-Oct 2018;11(5):727-731.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : XI0175000 CHEMICAL NAME : 4-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 6-(2-ethoxy-1-naphthamido)- 3,3-dimethyl-7-oxo-, monosodium salt CAS REGISTRY NUMBER : 985-16-0 LAST UPDATED : 199612 DATA ITEMS CITED : 10 MOLECULAR FORMULA : C21-H22-N2-O5-S.Na MOLECULAR WEIGHT : 437.50 WISWESSER LINE NOTATION : T45 ANV ESTJ F1 F1 GVQ CMV- BL66J CO2 &-NA- HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Human - woman DOSE/DURATION : 3200 mg/kg/20D-I TOXIC EFFECTS : Gastrointestinal - hypermotility, diarrhea Liver - jaundice, cholestatic Skin and Appendages - dermatitis, other (after systemic exposure) REFERENCE : AJGAAR American Journal of Gastroenterology. (American College of Gastroenterology, Inc., 428 E. Preston St., Baltimore, MD 21202) V.21- 1954- Volume(issue)/page/year: 88,1960,1993 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Human - woman DOSE/DURATION : 4560 mg/kg/19D-I TOXIC EFFECTS : Blood - agranulocytosis REFERENCE : JAMAAP JAMA, Journal of the American Medical Association. (AMA, 535 N. Dearborn St., Chicago, IL 60610) V.1- 1883- Volume(issue)/page/year: 232,1150,1975 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Human - child DOSE/DURATION : 450 mg/kg/3D TOXIC EFFECTS : Liver - other changes Blood - leukopenia Blood - eosinophilia REFERENCE : AJDCAI American Journal of Diseases of Children. (AMA, 535 N. Dearborn St., Chicago, IL 60610) V.1-80(3), 1911-50; V.100- 1960- Volume(issue)/page/year: 135,52,1981 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Human - man DOSE/DURATION : 3100 mg/kg/18D-I TOXIC EFFECTS : Kidney, Ureter, Bladder - interstitial nephritis Kidney, Ureter, Bladder - proteinuria Kidney, Ureter, Bladder - hematuria REFERENCE : JAMAAP JAMA, Journal of the American Medical Association. (AMA, 535 N. Dearborn St., Chicago, IL 60610) V.1- 1883- Volume(issue)/page/year: 244,2609,1980 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Human - man DOSE/DURATION : 429 mg/kg/23D-I TOXIC EFFECTS : Blood - agranulocytosis REFERENCE : JAMAAP JAMA, Journal of the American Medical Association. (AMA, 535 N. Dearborn St., Chicago, IL 60610) V.1- 1883- Volume(issue)/page/year: 232,1152,1975 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 1 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : RPTOAN Russian Pharmacology and Toxicology (English Translation). Translation of FATOAO. (Euromed Pub., 33, Woodlands Rd., Surbiton, Surrey, UK) V.30- 1967- Volume(issue)/page/year: 37,69,1974 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Mammal - dog DOSE/DURATION : 633 mg/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea Gastrointestinal - changes in structure or function of salivary glands REFERENCE : TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 6,220,1964 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Mammal - species unspecified DOSE/DURATION : 1266 mg/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold Behavioral - muscle weakness Lungs, Thorax, or Respiration - dyspnea REFERENCE : TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 6,220,1964 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intramuscular SPECIES OBSERVED : Mammal - species unspecified DOSE/DURATION : 2955 mg/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold Behavioral - muscle weakness Lungs, Thorax, or Respiration - dyspnea REFERENCE : TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 6,220,1964 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X3706 No. of Facilities: 288 (estimated) No. of Industries: 1 No. of Occupations: 8 No. of Employees: 14341 (estimated) No. of Female Employees: 11125 (estimated)

安全

• 符号: GHS08
• 信号词: Danger
• 危害声明: H317-H334
• 警示性声明: P261-P280-P342 + P311
• 危害码 (欧洲): Xn
• 风险声明 (欧洲): 42/43
• 安全声明 (欧洲): 22-36/37-45
• 危险品运输编码: NONH for all modes of transport
• RTECS号: XI0175000