CHEMICAL IDENTIFICATION
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RTECS NUMBER :
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XI0175000
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CHEMICAL NAME :
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4-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 6-(2-ethoxy-1-naphthamido)- 3,3-dimethyl-7-oxo-, monosodium salt
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CAS REGISTRY NUMBER :
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985-16-0
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LAST UPDATED :
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199612
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DATA ITEMS CITED :
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10
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MOLECULAR FORMULA :
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C21-H22-N2-O5-S.Na
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MOLECULAR WEIGHT :
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437.50
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WISWESSER LINE NOTATION :
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T45 ANV ESTJ F1 F1 GVQ CMV- BL66J CO2 &-NA-
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Intravenous
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SPECIES OBSERVED :
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Human - woman
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DOSE/DURATION :
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3200 mg/kg/20D-I
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TOXIC EFFECTS :
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Gastrointestinal - hypermotility, diarrhea Liver - jaundice, cholestatic Skin and Appendages - dermatitis, other (after systemic exposure)
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REFERENCE :
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AJGAAR American Journal of Gastroenterology. (American College of Gastroenterology, Inc., 428 E. Preston St., Baltimore, MD 21202) V.21- 1954- Volume(issue)/page/year: 88,1960,1993
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Intravenous
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SPECIES OBSERVED :
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Human - woman
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DOSE/DURATION :
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4560 mg/kg/19D-I
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TOXIC EFFECTS :
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Blood - agranulocytosis
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REFERENCE :
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JAMAAP JAMA, Journal of the American Medical Association. (AMA, 535 N. Dearborn St., Chicago, IL 60610) V.1- 1883- Volume(issue)/page/year: 232,1150,1975
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Intravenous
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SPECIES OBSERVED :
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Human - child
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DOSE/DURATION :
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450 mg/kg/3D
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TOXIC EFFECTS :
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Liver - other changes Blood - leukopenia Blood - eosinophilia
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REFERENCE :
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AJDCAI American Journal of Diseases of Children. (AMA, 535 N. Dearborn St., Chicago, IL 60610) V.1-80(3), 1911-50; V.100- 1960- Volume(issue)/page/year: 135,52,1981
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Intravenous
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SPECIES OBSERVED :
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Human - man
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DOSE/DURATION :
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3100 mg/kg/18D-I
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TOXIC EFFECTS :
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Kidney, Ureter, Bladder - interstitial nephritis Kidney, Ureter, Bladder - proteinuria Kidney, Ureter, Bladder - hematuria
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REFERENCE :
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JAMAAP JAMA, Journal of the American Medical Association. (AMA, 535 N. Dearborn St., Chicago, IL 60610) V.1- 1883- Volume(issue)/page/year: 244,2609,1980
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Intravenous
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SPECIES OBSERVED :
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Human - man
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DOSE/DURATION :
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429 mg/kg/23D-I
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TOXIC EFFECTS :
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Blood - agranulocytosis
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REFERENCE :
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JAMAAP JAMA, Journal of the American Medical Association. (AMA, 535 N. Dearborn St., Chicago, IL 60610) V.1- 1883- Volume(issue)/page/year: 232,1152,1975
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Intravenous
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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1 gm/kg
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TOXIC EFFECTS :
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Details of toxic effects not reported other than lethal dose value
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REFERENCE :
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RPTOAN Russian Pharmacology and Toxicology (English Translation). Translation of FATOAO. (Euromed Pub., 33, Woodlands Rd., Surbiton, Surrey, UK) V.30- 1967- Volume(issue)/page/year: 37,69,1974
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Intravenous
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SPECIES OBSERVED :
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Mammal - dog
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DOSE/DURATION :
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633 mg/kg
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TOXIC EFFECTS :
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Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea Gastrointestinal - changes in structure or function of salivary glands
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REFERENCE :
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TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 6,220,1964
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Intraperitoneal
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SPECIES OBSERVED :
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Mammal - species unspecified
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DOSE/DURATION :
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1266 mg/kg
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TOXIC EFFECTS :
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Behavioral - convulsions or effect on seizure threshold Behavioral - muscle weakness Lungs, Thorax, or Respiration - dyspnea
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REFERENCE :
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TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 6,220,1964
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Intramuscular
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SPECIES OBSERVED :
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Mammal - species unspecified
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DOSE/DURATION :
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2955 mg/kg
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TOXIC EFFECTS :
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Behavioral - convulsions or effect on seizure threshold Behavioral - muscle weakness Lungs, Thorax, or Respiration - dyspnea
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REFERENCE :
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TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 6,220,1964 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X3706 No. of Facilities: 288 (estimated) No. of Industries: 1 No. of Occupations: 8 No. of Employees: 14341 (estimated) No. of Female Employees: 11125 (estimated)
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