330784-47-9

• 常用中文名：阿伐那非
• 常用英文名：Avanafil
• CAS号：330784-47-9
• 分子式：C₂₃H₂₆ClN₇O₃
• 分子量：483.951
• 相关类别： 生物化工 抑制剂 代谢(Metabolism) PDE 抑制剂
• 发布时间：2018-08-04 14:41:48
• 更新时间：2026-07-12 17:59:53
• Avanafil(TA-1790)是高活性PDE-5抑制剂,IC50为5.2 nM,对PDE1,PDE6和PDE11活性较低。

名称

• 中文名: 阿伐那非
• 英文名: avanafil
• 中文别名: 阿伐那非-[13C,]/精确称量; 阿伐那非330784-|含量|医药; 阿伐那非,阿伐; 阿伐那非|阿伐那非330784-|优质|可批发; 阿伐那非330784-|优质阿伐那非; 化合物：Avanafil; 天然提取物发阿伐那非; 盐酸阿伐那非; 4-[(3-氯-4-甲氧基苄基)氨基]-2-[2-(羟甲基)-1-吡咯烷基]-N-(2-嘧啶基甲基)-5-嘧啶甲磺酰胺; 阿伐那非|||TA1790; 阿伐那非330784-|批发|直销|供应; 化合物:Avanafil; 盐酸盐阿伐那非; 2-[(S)-2-(羟甲基)-1-吡咯烷基]-4-[(3-氯-4-甲氧基苄基)氨基]-N-[(2-嘧啶基)甲基]-5-嘧啶甲酰胺; 优质阿伐那非|阿伐那非330-9; 供应/可提供免费样品阿伐那非; 阿伐那非-D4; [13C5,15N]-阿伐那非; 阿伐那非|阿伐那非330784-|阿伐那非99; 阿伐那非盐酸; 特卖【供应】纯天然 阿伐那非|330-9; 阿法那非; 阿伐那菲; 阿伐那非|阿伐那非330-9|阿伐那非; (S)-4-((3-氯-4-甲氧基苄基)氨基)-2-(2-羟甲基)吡咯烷-1-基)-N-(嘧啶-2-基甲基)嘧啶-5-甲酰胺; 阿伐那非,4-[(3-氯-4-甲氧基苄基)氨基]-2-[2-(羟甲基)-1-吡咯烷基]-N-(2-嘧啶基甲基)-5-嘧啶甲磺酰胺; 阿伐那非标准品; 阿伐那非330784-|批发|直销|供应|优质; 阿伐那非 开票名称:4-[[(3-氯-4-甲氧基苯基)甲基]氨基]-2-[(2S)-2-羟甲基-1-吡咯烷基]-5-嘧啶羧酸乙酯; 阿伐那非|330-9; 【供应】纯天然阿伐那非; 【直销没有贸易赚钱中间价】阿伐那非; 阿伐那非,10 MM DMSO 溶液; 阿伐那非.阿伐那菲; 阿伐那非原料; 直销|阿伐那非330-9; 阿瓦那非; 便携式多参数水质分析仪; 发阿伐那非; 阿伐那非|330-9阿伐那非
• 英文别名: (S)-4-((3-Chloro-4-Methoxybenzyl)amino)-2-(2-(hydroxyMethyl)pyrrolidin-1-yl)-N-(pyriMidin-2-ylMethyl)pyriMidine-5-cboxaMide; (S)-4-[(3-Chloro-4-methoxybenzyl)amino]-2-[2-(hydroxymethyl)-1-pyrrolidinyl]-N-(2pyrimidinylmethyl)-5-pyrimidinecboxamide; avanfil; Natural Sex Steroid Hormones Avanafil Hormone Powder C23H26ClN7O3; 4-((3-chloro-4-Methoxybenzyl)amino)-2-(2-(hydroxyMethyl)pyrrolidin-1-yl)-N-(pyriMidin-2-ylMethyl)pyriMidine-5-cboxaMide; 4-[(3-Chloro-4-methoxybenzyl)amino]-2-[(2S)-2-(hydroxymethyl)-1-pyrrolidinyl]-N-(2-pyrimidinylmethyl)-5-pyrimidinecboxamide; Avanafil 4-[(3-Chloro-4-methoxybenzyl)amino]-2-[2-(hydroxymethyl)-1-pyrrolidinyl]-N-(2-pyrimidinylmethyl)-5-pyrimidinecboxamide; 4-[(3-Chloro-4-methoxybenzyl)amino]-2-[(2S)-2-(hydroxymethyl)-1-pyrrolidinyl]-N-(2-pyrimidinylmethyl)-5-pyrimidinecarboxamide; (S)-4-chloro-6-((3-chloro-4-methoxybenzyl)amino)-2-(2-(hydroxymethyl)pyrrolidin-1-yl)-N-(pyrimidin-2-ylmethyl)pyrimidine-6-cboxamide; TA-1790; 4-[(3-Chloro-4-methoxybenzyl)amino]-2-[2-(hydroxymethyl)-1-pyrrolidinyl]-N-(2-pyrimidinylmethyl)-5-pyrimidinecboxamide; 4-[(3-Chloro-4-methoxybenzyl)amino]; 4-[(3-Chloro-4-methoxybenzyl)amino]-2-[(S)-2-(hydroxymethyl)-1-pyrrolidyl]-N-[(2-pyrimidyl)methyl]-5-pyrimidinecboxamide; phmaceutical raw material suppliers Avanafil 330-9 high quality lower Prices; AVANAFE; U-53; (S)-4-[(3-Chloro-4-methoxybenzyl)amino]-2-[2-(hydroxymethyl)-1-pyrrolidinyl]-N-(2pyrimidinylmethyl)-5-pyrimidinecarboxamide; Stendra; Avanafil PDE5 inhibitor; Avanafil, Standa; AvanafilQ: What is Avanafil Q: What is the CAS Number of Avanafil Q: What is the storage condition of Avanafil Q: What e the applications of Avanafil; Avanafi; (S)-4-chloro-6-((3-chloro-4-methoxybenzyl)amino)-2-(2-(hydroxymethyl)pyrrolidin-1-yl)-N-(pyrimidin-2-ylmethyl)pyrimidine-5-cboxamide; Avanafl; 4-[(3-Chloro-4-methoxybenzyl)amino]-2-[(2S)-2-(hydroxymethyl)pyrrolidin-1-yl]-N-(pyrimidin-2-ylmethyl)pyrimidine-5-cboxamide; (S)-4-((3-Chloro-4-methoxybenzyl)amino)-2-(2-(hydroxymethyl)pyrrolidin-1-yl)-N-(pyrimidin-2-yl; Avanafil - Bio-X; Avanafil 13C5 15NQ: What is Avanafil 13C5 15N Q: What is the CAS Number of Avanafil 13C5 15N Q: What is the storage condition of Avanafil 13C5 15N Q: What e the applications of Avanafil 13C5 15N; vanafil; Avanafil, 10 mM in DMSO; Piperazinylpropylmethyldimethoxysilane; Avanafil invoicing name: 4- [[(3-chloro-4-methoxyphenyl) methyl] amino] -2- [(2S) -2-hydroxymethyl-1-pyrrolidine] -5-pyrimidine cboxylate ethyl ester; Avanafil //BP; O cut the non; [13C5, 15N]-Avanafil; 4-[[(3-Chloro-4-Methoxyphenyl)Methyl] amino]-2-[(2S)-2-(hydroxyMethyl)-1-pyrrolidinyl]-N-(2-pyriMidinylMethyl)-5-pyriMidinecboxaMide; avanafil:4-((3-chloro-4-methoxybenzyl)amino)-2-(2-(hydroxymethyl)-1-pyrrolidinyl)-n-(2-pyrimidinylmethyl)-5-pyrimidinecboxamide: (s)-2-(2-hydroxymethyl-1-pyrrolidinyl)-4-(3-chloro-4-methoxybenzylami; Avanafil (usan/inn); 4-[(3-Chloro-4-methoxybenzyl)amino] Avanafil; Avanafil(TA-1790); Avanafil-d4; Avanafil-d3; Avanafil 100 μg/mL in Acetonitrile:Dimethylsulfoxide; Avanafil white powder; U 53; (S)-2-(2-Hydroxymethyl-1-pyrrolidinyl)-4-(3-chloro-4-methoxybenzylamino)-5-[(2-pyrimidinylmethyl)cbamoyl]pyrimidine; D03217; Avanafil , Stendra

物化性质

• 密度: 1.4±0.1 g/cm3
• 熔点: 150-152ºC
• 分子式: C₂₃H₂₆ClN₇O₃
• 分子量: 483.951
• 精确质量: 483.178558
• PSA: 125.39000
• LogP: 3.52
• 外观性状: 白色固体
• 折射率: 1.651
• 储存条件: Refrigerator

生物活性

• 描述: Avanafil(TA-1790)是高活性PDE-5抑制剂,IC50为5.2 nM,对PDE1,PDE6和PDE11活性较低。
• 相关类别:
  信号通路 >> 代谢酶/蛋白酶 >> 磷酸二酯酶(PDE)
  研究领域 >> 心血管疾病
• 参考文献:

  [1]. Kotera J, et al. Avanafil, a potent and highly selective phosphodiesterase-5 inhibitor for erectile dysfunction. J Urol. 2012 Aug;188(2):668-74.

  [2]. Wang R, et al. Selectivity of avanafil, a PDE5 inhibitor for the treatment of erectile dysfunction: implications for clinical safety and improved tolerability. J Sex Med. 2012 Aug;9(8):2122-9.

  [3]. Mochida H, et al. Avanafil, a highly selective phosphodiesterase type 5 inhibitor for erectile dysfunction, shows good safety profiles for retinal function and hemodynamics in anesthetized dogs. J Urol. 2013 Aug;190(2):799-806.

安全

• 海关编码: 2933990090

海关

海关编码	2933990090
中文概述	2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%