25875-51-8

• 常用中文名：盐酸氯苯胍
• 常用英文名：Robenidine hydrochloride
• CAS号：25875-51-8
• 分子式：C₁₅H₁₃Cl₂N₅
• 分子量：334.20
• 相关类别： 研究领域 感染
• 发布时间：2018-09-08 18:25:09
• 更新时间：2026-07-18 22:54:03
• 罗伯尼丁是一种抗球虫剂,可用于研究由艾美耳属寄生虫引起的球虫病[1]。

名称

• 中文名: 罗贝胍
• 英文名: 1,2-bis[(E)-(4-chlorophenyl)methylideneamino]guanidine
• 中文别名: 1,3-双-(对氯苯叉氨基)胍盐酸盐; N',2-双(4-氯亚苄基)肼-1-甲亚胺肼; 1,3-双(对氯苯叉氨基)胍盐酸盐; 氯苯胍标准品
• 英文别名: Cytostat; N',2-BIS(4-CHLOROBENZYLIDENE)HYDRAZINECBOXIMIDOHYDRAZIDE; Chimcoccide; Khimcoccid; Khimkoktsid; Robenidin; Khimcoecid; WAKO91; EINECS 247-308-3; Robenidine; Khimkoktside; 1,2-bis[(4-chlorophenyl)methylideneamino]guanidine hydrochloride; Bis[(4-chlorophenyl)methylene]cbonimidic; N, N'-Bis (p-chlorobenzylideneamino) quanidine; bis[(4-chlorophenyl)methylene]cbonimidic dihydrazide hydrochloride; Cbonimidic dihydrazide, 2,2'-bis[(4-chlorophenyl)methylene]

物化性质

• 密度: 1.33 g/cm3
• 沸点: 488.1ºC at 760 mmHg
• 分子式: C₁₅H₁₃Cl₂N₅
• 分子量: 334.20
• 闪点: 249ºC
• 精确质量: 333.05500
• PSA: 72.63000
• LogP: 4.35690
• 外观性状: 固体
• 蒸汽压: 0mmHg at 25°C
• 折射率: 1.634
• 储存条件: 室温

生物活性

• 描述: 罗伯尼丁是一种抗球虫剂,可用于研究由艾美耳属寄生虫引起的球虫病[1]。
• 相关类别:
  研究领域 >> 感染
• 参考文献:

  [1]. Krollenbrock A, et, al. Robenidine Analogues Are Potent Antimalarials in Drug-Resistant Plasmodium falciparum. ACS Infect Dis. 2021 Jul 9;7(7):1956-1968.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : ME8650000 CHEMICAL NAME : Guanidine, 1,3-bis((p-chlorobenzylidene)amino)- CAS REGISTRY NUMBER : 25875-51-8 LAST UPDATED : 199612 DATA ITEMS CITED : 5 MOLECULAR FORMULA : C15-H13-Cl2-N5 MOLECULAR WEIGHT : 334.23 WISWESSER LINE NOTATION : GR D1 UNMYUM&MNU1R DG HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 1350 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : VETNAL Veterinariya. Veterinary Science. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1924- Volume(issue)/page/year: 57(9),53,1981 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 1212 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : VETNAL Veterinariya. Veterinary Science. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1924- Volume(issue)/page/year: 53(11),69,1976 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 1245 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : VETNAL Veterinariya. Veterinary Science. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1924- Volume(issue)/page/year: 57(9),53,1981 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Bird - chicken DOSE/DURATION : 500 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : VETNAL Veterinariya. Veterinary Science. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1924- Volume(issue)/page/year: 57(9),53,1981 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Bird - duck DOSE/DURATION : 1017 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : VETNAL Veterinariya. Veterinary Science. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1924- Volume(issue)/page/year: 57(9),53,1981

合成路线

36062-19-8 3848-36-0 ~95% 25875-51-8

文献：Zaionts, V. I.; Zakharova, N. A.; Korovitskaya, L. A.; Agrest, F. B.; Krylov, M. V.; et al. Pharmaceutical Chemistry Journal, 1982 , vol. 16, # 8 p. 637 - 638 Khimiko-Farmatsevticheskii Zhurnal, 1982 , vol. 16, # 8 p. 972 - 973