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25875-51-8

25875-51-8 structure

25875-51-8 structure

Name: Robenidine hydrochloride
Chemical Name: 1,2-bis[(E)-(4-chlorophenyl)methylideneamino]guanidine
CAS Number: 25875-51-8
Molecular Formula: C₁₅H₁₃Cl₂N₅
Molecular Weight: 334.20
Catalog: Research Areas Infection
Create Date: 2018-09-08 18:25:09
Modify Date: 2026-07-18 22:54:03
Robenidine is a coccidiostat agent that can be used for the research of coccidiosis caused by parasites in the Eimeria genus[1].

Name	1,2-bis[(E)-(4-chlorophenyl)methylideneamino]guanidine
Synonyms	Cytostat N',2-BIS(4-CHLOROBENZYLIDENE)HYDRAZINECBOXIMIDOHYDRAZIDE Chimcoccide Khimcoccid Khimkoktsid Robenidin Khimcoecid WAKO91 EINECS 247-308-3 Robenidine Khimkoktside 1,2-bis[(4-chlorophenyl)methylideneamino]guanidine hydrochloride Bis[(4-chlorophenyl)methylene]cbonimidic N, N'-Bis (p-chlorobenzylideneamino) quanidine bis[(4-chlorophenyl)methylene]cbonimidic dihydrazide hydrochloride Cbonimidic dihydrazide, 2,2'-bis[(4-chlorophenyl)methylene]

Description	Robenidine is a coccidiostat agent that can be used for the research of coccidiosis caused by parasites in the Eimeria genus[1].
Related Catalog	Research Areas >> Infection
References	[1]. Krollenbrock A, et, al. Robenidine Analogues Are Potent Antimalarials in Drug-Resistant Plasmodium falciparum. ACS Infect Dis. 2021 Jul 9;7(7):1956-1968.

Density	1.33 g/cm3
Boiling Point	488.1ºC at 760 mmHg
Molecular Formula	C₁₅H₁₃Cl₂N₅
Molecular Weight	334.20
Flash Point	249ºC
Exact Mass	333.05500
PSA	72.63000
LogP	4.35690
Vapour Pressure	0mmHg at 25°C
Index of Refraction	1.634

CHEMICAL IDENTIFICATION

RTECS NUMBER :: ME8650000

CHEMICAL NAME :: Guanidine, 1,3-bis((p-chlorobenzylidene)amino)-

CAS REGISTRY NUMBER :: 25875-51-8

LAST UPDATED :: 199612

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C15-H13-Cl2-N5

MOLECULAR WEIGHT :: 334.23

WISWESSER LINE NOTATION :: GR D1 UNMYUM&MNU1R DG

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1350 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: VETNAL Veterinariya. Veterinary Science. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1924- Volume(issue)/page/year: 57(9),53,1981

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1212 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: VETNAL Veterinariya. Veterinary Science. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1924- Volume(issue)/page/year: 53(11),69,1976

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 1245 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: VETNAL Veterinariya. Veterinary Science. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1924- Volume(issue)/page/year: 57(9),53,1981

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - chicken

DOSE/DURATION :: 500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: VETNAL Veterinariya. Veterinary Science. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1924- Volume(issue)/page/year: 57(9),53,1981

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - duck

DOSE/DURATION :: 1017 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: VETNAL Veterinariya. Veterinary Science. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1924- Volume(issue)/page/year: 57(9),53,1981

36062-19-8 structure

36062-19-8

3848-36-0 structure

3848-36-0

~95%

25875-51-8 structure

25875-51-8

Literature: Zaionts, V. I.; Zakharova, N. A.; Korovitskaya, L. A.; Agrest, F. B.; Krylov, M. V.; et al. Pharmaceutical Chemistry Journal, 1982 , vol. 16, # 8 p. 637 - 638 Khimiko-Farmatsevticheskii Zhurnal, 1982 , vol. 16, # 8 p. 972 - 973

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