15087-02-2

• 常用中文名：β-雌二醇17-(β-D-葡糖醛酸)钠盐
• 常用英文名：β-Estradiol 17-(β-D-glucuronide) sodium salt
• CAS号：15087-02-2
• 分子式：C₂₄H₃₁NaO₈
• 分子量：470.5
• 相关类别： 研究领域 内分泌
• 发布时间：2017-07-30 23:51:42
• 更新时间：2026-07-03 12:03:36
• 众所周知,雌二醇17-(β-D-葡萄糖醛酸)钠是雌激素的代谢物,可导致人类肝内胆汁淤积[1]。

名称

• 中文名: β-雌二醇17-(β-D-葡糖醛酸)钠盐
• 英文名: sodium,3,4,5-trihydroxy-6-[(3-hydroxy-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-17-yl)oxy]oxane-2-carboxylic acid
• 中文别名: Β-雌二醇17-(Β-D-葡糖醛酸)钠盐; 化合物:Estradiol 17-(β-D-Glucuronide) (sodium salt); 雌二醇杂质14; 雌二醇17-O-Β-D-葡萄糖醛酸钠; 雌二醇17-O-Β-D-葡糖醛酸,钠盐; Β雌二醇17-(Β-D-葡萄糖醛酸)钠盐; 化合物：Estradiol 17-(β-D-Glucuronide) (sodium salt); β雌二醇17-(β-D-葡萄糖醛酸)钠盐
• 英文别名: 1, 3, 5-ESTRATRIEN-3, 17β-DIOL 17-GLUCOSIDURONATE SODIUM SALT; 3,17BETA-DIHYDROXY-1,3,5-ESTRATRIENE 17-GLUCURONIDE SODIUM SALT; BETA-ESTRADIOL 17-(BETA-D-GLUCURONIDE) SODIUM SALT; oestradiol 17-(beta-D-glucuronide), sodium salt; Clazuril Impurity3 (Clazuril ImpurityC); 17-BETA-ESTRADIOL 17-GLUCURONIDE SODIUM SALT; Hexopyranosiduronic acid, 3-hydroxyestra-1,3,5(10)-trien-17-yl, sodium salt (1:1); 1,3,5-ESTRATRIENE-3,17BETA-DIOL 17-GLUCURONIDE SODIUM SALT; Estradiol 17-O-β-D-glucuronide, sodium salt; Estradiol Impurity 14; β-Estradiol 17-(β- D -glucuronide) sodium salt; 1,3,5-Estratriene-3,17β-diol 17-glucuronide, 3,17β-Dihydroxy-1,3,5-estratriene 17-glucuronide; B-ESTRADIOL 17-(B-D-GLUCURONIDE)SODIUM; sodium 3-hydroxyestra-1,3,5-trien-17β-yl-β-D-glucopyranosuronate; 3,17β-Dihydroxy-1,3,5-estratriene 17-glucuronide; b-Estradiol 17-(b-D-glucuronide) sodium salt; 17β-Estradiol 17-Glucuronide Sodium Salt; sodium:(2S,3S,4S,5R,6R)-3,4,5-trihydroxy-6-[[(8R,9S,13S,14S,17S)-3-hydroxy-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-17-yl]oxy]oxane-2-cboxylate; Estradiol 17-(β-D-Glucuronide) sodium salt; 1,3,5-Estratriene-3,17β-diol 17-glucuronide; 1,3,5-ESTRATRIEN-3,17-BETA-DIOL 17-GLUCOSIDURONATE SODIUM SALT

物化性质

• 分子式: C₂₄H₃₁NaO₈
• 分子量: 470.5
• 精确质量: 470.19166222
• PSA: 136.68000
• LogP: 1.52570
• 储存条件: -20°C

生物活性

• 描述: 众所周知,雌二醇17-(β-D-葡萄糖醛酸)钠是雌激素的代谢物,可导致人类肝内胆汁淤积[1]。
• 相关类别:
  研究领域 >> 内分泌
  研究领域 >> 代谢疾病
• 靶点:

  Human Endogenous Metabolite

• 参考文献:

  [1]. Kinbara S, et al. Improvement of estradiol-17 beta-D-glucuronide-induced cholestasis by sodium tauroursodeoxycholate therapy in rats. Scand J Gastroenterol. 1997;32(9):947-952.

安全

• 符号: GHS07, GHS08
• 信号词: Warning
• 危害声明: H302-H312-H332-H351
• 警示性声明: P280
• 个人防护装备: Eyeshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
• 危害码 (欧洲): Xn: Harmful;
• 风险声明 (欧洲): R20/21/22
• 安全声明 (欧洲): S22
• 危险品运输编码: NONH for all modes of transport

合成路线

14364-66-0 ~43% 15087-02-2

文献：Numazawa, Mitsuteru; Nagaoka, Masao; Tsuji, Masachika; Osawa, Yoshio Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1983 , # 1 p. 121 - 125

19590-55-7 ~% 15087-02-2

文献：Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , # 1 p. 121 - 125

86030-37-7 ~% 15087-02-2

文献：Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , # 1 p. 121 - 125

21085-72-3 ~% 15087-02-2

文献：Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , # 1 p. 121 - 125

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