β-Estradiol 17-(β-D-glucuronide) sodium salt

Modify Date: 2024-01-04 18:24:41

β-Estradiol 17-(β-D-glucuronide) sodium salt Structure
β-Estradiol 17-(β-D-glucuronide) sodium salt structure
Common Name β-Estradiol 17-(β-D-glucuronide) sodium salt
CAS Number 15087-02-2 Molecular Weight 471.496
Density N/A Boiling Point N/A
Molecular Formula C24H32NaO8 Melting Point N/A
MSDS Chinese USA Flash Point N/A
Symbol GHS07 GHS08
GHS07, GHS08
Signal Word Warning

 Use of β-Estradiol 17-(β-D-glucuronide) sodium salt


Estradiol 17-(β-D-Glucuronide) sodium, a metabolite of estrogen, is well known to cause intrahepatic cholestasis in humans[1].

 Names

Name sodium,3,4,5-trihydroxy-6-[(3-hydroxy-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-17-yl)oxy]oxane-2-carboxylic acid
Synonym More Synonyms

  Biological Activity

Description Estradiol 17-(β-D-Glucuronide) sodium, a metabolite of estrogen, is well known to cause intrahepatic cholestasis in humans[1].
Related Catalog
Target

Human Endogenous Metabolite

References

[1]. Kinbara S, et al. Improvement of estradiol-17 beta-D-glucuronide-induced cholestasis by sodium tauroursodeoxycholate therapy in rats. Scand J Gastroenterol. 1997;32(9):947-952.

 Chemical & Physical Properties

Molecular Formula C24H32NaO8
Molecular Weight 471.496
Exact Mass 471.199493
PSA 136.68000
LogP 1.52570
Storage condition -20°C

 Safety Information

Symbol GHS07 GHS08
GHS07, GHS08
Signal Word Warning
Hazard Statements H302-H312-H332-H351
Precautionary Statements P280
Personal Protective Equipment Eyeshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
Hazard Codes Xn: Harmful;
Risk Phrases R20/21/22
Safety Phrases S22
RIDADR NONH for all modes of transport

 Synthetic Route

~43%

β-Estradiol 17-(β-D-glucuronide) sodium salt Structure

β-Estradiol 17-...

CAS#:15087-02-2

Literature: Numazawa, Mitsuteru; Nagaoka, Masao; Tsuji, Masachika; Osawa, Yoshio Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1983 , # 1 p. 121 - 125

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β-Estradiol 17-(β-D-glucuronide) sodium salt Structure

β-Estradiol 17-...

CAS#:15087-02-2

Literature: Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , # 1 p. 121 - 125

~%

β-Estradiol 17-(β-D-glucuronide) sodium salt Structure

β-Estradiol 17-...

CAS#:15087-02-2

Literature: Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , # 1 p. 121 - 125

~%

β-Estradiol 17-(β-D-glucuronide) sodium salt Structure

β-Estradiol 17-...

CAS#:15087-02-2

Literature: Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , # 1 p. 121 - 125

 Synonyms

Hexopyranosiduronic acid, 3-hydroxyestra-1,3,5(10)-trien-17-yl, sodium salt (1:1)