21593-23-7

• 常用中文名：头孢匹林
• 常用英文名：Cefapirin
• CAS号：21593-23-7
• 分子式：C₁₇H₁₇N₃O₆S₂
• 分子量：423.46300
• 相关类别： 信号通路 抗感染 细菌
• 发布时间：2016-04-20 23:10:47
• 更新时间：2026-07-12 05:40:52
• 头孢匹林是一种头孢菌素类抗生素,具有广谱抗菌活性[1][2][3]。

名称

• 中文名: 头孢匹林
• 英文名: cephapirin
• 中文别名: 头孢匹啉; 头孢替安杂质39; 头孢匹林 标准品; 头孢吡林; (6R,7R)-3-(乙酰氧基甲基)-8-氧代-7-(2-(吡啶-4-基硫基)乙酰氨基)-5-硫杂-1-氮杂双环[4.2.0]辛烷-2-烯-2-羧酸; 头孢吡啶
• 英文别名: 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-cboxylic acid, 3-[(acetyloxy)methyl]-8-oxo-7-[[2-(4-pyridinylthio)acetyl]amino]-, (6R,7R); (6R)-3-acetoxymethyl-8-oxo-7t-(2-pyridin-4-ylsulfanyl-acetylamino)-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid; (6R-trans)-3-[(Acetyloxy)Methyl]-8-oxo-7- [[(4-pyridinylthio)acetyl]amino]; 7-(2-(4-pyridylthio)acetamido)cephalosporanic acid; (6R,7R)-3-(acetyloxymethyl)-8-oxo-7-[(2-pyridin-4-ylsulfanylacetyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid; Cephapirine; 7-[2-(4-Pyridylthio)acetamido]chalosporanic acid; Cefa; Cefaprin sodium; Cefapirin acid; Chaprin; Cefapirina; Cefapirine; (6R,7R)-3-[(Acetyloxy)Methyl]-8-oxo-7-[[(4-pyridinylthio)acetyl]amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-cboxylic Acid; (6R)-3-acetoxymethyl-8-oxo-7t-(2-pyridin-4-ylsulfanyl-acetylamino)-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-cboxylic acid; Cefotiam Impurity 39; Cefapirinum; (6R,7R)-3-(Acetoxymethyl)-8-oxo-7-(2-(pyridin-4-ylthio)acetamido)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-cboxylic acid; 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-cboxylic acid, 3-(hydroxymethyl)-8-oxo-7-[2-(4-pyridylthio)acetamido]-, acetate (ester) (8CI); 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-cboxylic acid, 3-[(acetyloxy)methyl]-8-oxo-7-[[(4-pyridinylthio)acetyl]amino]-, (6R-trans); 5-Thia-1-azabicyclo4.2.0oct-2-ene-2-cboxylic acid, 3-(acetyloxy)methyl-8-oxo-7-(4-pyridinylthio)acetylamino-, (6R,7R); Cefaprin; CEPR; C06896

物化性质

• 分子式: C₁₇H₁₇N₃O₆S₂
• 分子量: 423.46300
• 精确质量: 423.05600
• PSA: 179.99000
• LogP: 1.25360
• 蒸汽压: 6.98E-26mmHg at 25°C
• 储存条件: -20°C，密闭，干燥

生物活性

• 描述: 头孢匹林是一种头孢菌素类抗生素,具有广谱抗菌活性[1][2][3]。
• 相关类别:
  研究领域 >> 感染
  信号通路 >> 抗感染 >> 细菌
• 体外研究: 头孢匹林(头孢匹林)通过浓度为0.09至12.5μg/mL的头孢匹林抑制金黄色葡萄球菌[2]。头孢匹林(头孢匹林)对表皮葡萄球菌、绿色葡萄球菌、化脓性葡萄球菌和肺炎双球菌的抑制作用低于1μg/mL[2]。
• 体内研究: 头孢匹林(头孢匹林)(200 mg；i.m.；奶牛)对感染金黄色葡萄球菌的奶牛有效[3]。
• 参考文献:

  [1]. Bran JL, et al. Clinical and in vitro evaluation of cephapirin, a new cephalosporin antibiotic. Antimicrob Agents Chemother. 1972 Jan;1(1):35-40.

  [2]. Axelrod J, et, al. Cephapirin: in vitro antibacterial spectrum. Appl Microbiol. 1971 Nov;22(5):904-8.

  [3]. Roy JP, et, al. Efficacy of a 5-day extended therapy program during lactation with cephapirin sodium in dairy cows chronically infected with Staphylococcus aureus. Can Vet J. 2009 Dec;50(12):1257-62.

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