526-94-3

• 常用中文名：酒石酸氢钠
• 常用英文名：Monosodium tartrate
• CAS号：526-94-3
• 分子式：C₄H₅NaO₆
• 分子量：172.069
• 相关类别： 有机原料 有机金属类化合物 有机钠
• 发布时间：2018-03-07 08:00:00
• 更新时间：2024-01-01 20:38:21
• 【用途一】
  用作分析试剂，也用于培养基的制备
  【用途二】
  可作生化试剂
  【用途三】
  检验钾、培养基。

名称

• 中文名: 酒石酸氢钠(一水)
• 英文名: Sodium Bitartrate
• 中文别名: 酒石酸氢钠,一水; 酒石酸氢钠,一水; 重酒石酸钠; 酒石酸氢钠; 酒石酸氢钠,单水合物; L-酒石酸氢钠; 酒石酸氢钠单水合物
• 英文别名: EINECS 208-400-9; Monosodium tartrate; Sodium bitartrate; MFCD00065393; Sodium hydrogen tartrate; Sodium 3-carboxy-2,3-dihydroxypropanoate; Butanedioic acid, 2,3-dihydroxy-, sodium salt (1:1); Tartaric acid, sodium salt, D-; Sodium bitartrate monohydrate; sodium,2,3,4-trihydroxy-4-oxobutanoate

物化性质

• 沸点: 399.3ºC at 760mmHg
• 熔点: 253 °C (dec.)(lit.)
• 分子式: C₄H₅NaO₆
• 分子量: 172.069
• 闪点: 209.4ºC
• 精确质量: 171.998383
• PSA: 117.89000
• 外观性状: 白色结晶粉末
• 储存条件:

  1.储存于阴凉、干燥、通风良好的库房。

  2.远离火种、热源。防止阳光直射。包装密封。

  3.应与酸类、食用化学品分开存放，切忌混储。储区应备有合适的材料收容泄漏物。

• 稳定性:

  按规格使用和贮存，不会发生分解，避免与氧化物接触

• 水溶解性: H2O: 0.1 M at 20 °C, clear, colorless
• 计算化学:

  1.疏水参数计算参考值（XlogP）:无

  2.氢键供体数量:3

  3.氢键受体数量:6

  4.可旋转化学键数量:3

  5.互变异构体数量:无

  6.拓扑分子极性表面积118

  7.重原子数量:11

  8.表面电荷:0

  9.复杂度:157

  10.同位素原子数量:0

  11.确定原子立构中心数量:0

  12.不确定原子立构中心数量:2

  13.确定化学键立构中心数量:0

  14.不确定化学键立构中心数量:0

  15.共价键单元数量:2

• 更多:

  1. 性状：无色结晶或白色结晶性粉末

  2. 密度（g/ cm³,25/4℃）：未确定

  3. 相对蒸汽密度（g/cm³,空气=1）：未确定

  4. 熔点（ºC）：253

  5. 沸点（ºC,常压）：未确定

  6. 沸点（ºC,8kPa）：未确定

  7. 折射率：未确定

  8. 闪点（ºC）：未确定

  9. 比旋光度（º）：未确定

  10. 自燃点或引燃温度（ºC）：未确定

  11. 蒸气压（kPa,25ºC）：未确定

  12. 饱和蒸气压（kPa,55.1ºC）：未确定

  13. 燃烧热（KJ/mol）：未确定

  14. 临界温度（ºC）：未确定

  15. 临界压力（KPa）：未确定

  16. 油水（辛醇/水）分配系数的对数值：未确定

  17. 爆炸上限（%,V/V）：未确定

  18. 爆炸下限（%,V/V）：未确定

  19. 溶解性：溶于水，不溶于乙醇,水溶液呈碱性。

MSDS

Name: Sodium Hydrogen Tartrate Monohydrate Material Safety Data Sheet Synonym: Butanedioic acid, 2,3-dihydroxy- (2R,3R)-, monosodium salt, monohydrate; Sodium hydrogen tartrate monohydrate CAS: 526-94-3 Section 1 - Chemical Product MSDS Name:Sodium Hydrogen Tartrate Monohydrate Material Safety Data Sheet Synonym:Butanedioic acid, 2,3-dihydroxy- (2R,3R)-, monosodium salt, monohydrate; Sodium hydrogen tartrate monohydrate Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS CAS# Chemical Name content EINECS# 526-94-3 Sodium bitartrate monohydrate 100 unlisted Hazard Symbols: None Listed. Risk Phrases: None Listed. Section 3 - HAZARDS IDENTIFICATION EMERGENCY OVERVIEW Not available. Potential Health Effects Eye: May cause eye irritation. Skin: May cause skin irritation. Ingestion: May cause irritation of the digestive tract. Inhalation: May cause respiratory tract irritation. Chronic: May cause kidney damage. Section 4 - FIRST AID MEASURES Eyes: In case of contact, immediately flush eyes with plenty of water for at least 15 minutes. Get medical aid. Skin: In case of contact, flush skin with plenty of water. Remove contaminated clothing and shoes. Get medical aid if irritation develops and persists. Wash clothing before reuse. Ingestion: If swallowed, do not induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an unconscious person. Get medical aid. Inhalation: If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid. Notes to Physician: Section 5 - FIRE FIGHTING MEASURES General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Dusts may be combustible when exposed to heat, flame, or oxidizing agents. Extinguishing Media: For small fires, use water spray, dry chemical, carbon dioxide or chemical foam. Section 6 - ACCIDENTAL RELEASE MEASURES General Information: Use proper personal protective equipment as indicated in Section 8. Spills/Leaks: Vacuum or sweep up material and place into a suitable disposal container. Avoid generating dusty conditions. Provide ventilation. Section 7 - HANDLING and STORAGE Handling: Wash thoroughly after handling. Use with adequate ventilation. Minimize dust generation and accumulation. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid breathing dust. Storage: Store in a cool, dry, well-ventilated area away from incompatible substances. Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION Engineering Controls: Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate ventilation to keep airborne concentrations low. Exposure Limits CAS# 526-94-3: CAS# 6131-98-2: Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to minimize contact with skin. Respirators: Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced. Section 9 - PHYSICAL AND CHEMICAL PROPERTIES Physical State: Crystalline powder Color: white Odor: none reported pH: acidic in solution Vapor Pressure: Not applicable. Viscosity: Not applicable. Boiling Point: Not applicable. Freezing/Melting Point: Not available. Autoignition Temperature: Not available. Flash Point: Not applicable. Explosion Limits, lower: Not available. Explosion Limits, upper: Not available. Decomposition Temperature: 426 deg F Solubility in water: Soluble. Specific Gravity/Density: Not available. Molecular Formula: C4H6O6.Na.H2O Molecular Weight: 190.09 Section 10 - STABILITY AND REACTIVITY Chemical Stability: Stable under normal temperatures and pressures. Conditions to Avoid: High temperatures, dust generation. Incompatibilities with Other Materials: Strong oxidizing agents. Hazardous Decomposition Products: Carbon monoxide, carbon dioxide. Hazardous Polymerization: Has not been reported Section 11 - TOXICOLOGICAL INFORMATION RTECS#: CAS# 526-94-3: WW8225000 CAS# 6131-98-2 unlisted. LD50/LC50: CAS# 526-94-3: Oral, mouse: LD50 = 4360 mg/kg. CAS# 6131-98-2. Carcinogenicity: Sodium hydrogen tartrate, anhydrous - Not listed by ACGIH, IARC, or NTP. Sodium bitartrate monohydrate - Not listed by ACGIH, IARC, or NTP. Other: See actual entry in RTECS for complete information. Section 12 - ECOLOGICAL INFORMATION Section 13 - DISPOSAL CONSIDERATIONS Products which are considered hazardous for supply are classified as Special Waste and the disposal of such chemicals is covered by regulations which may vary according to location. Contact a specialist disposal company or the local waste regulator for advice. Empty containers must be decontaminated before returning for recycling. Section 14 - TRANSPORT INFORMATION IATA Not regulated as a hazardous material. IMO Not regulated as a hazardous material. RID/ADR Not regulated as a hazardous material. Section 15 - REGULATORY INFORMATION European/International Regulations European Labeling in Accordance with EC Directives Hazard Symbols: Not available. Risk Phrases: Safety Phrases: WGK (Water Danger/Protection) CAS# 526-94-3: 1 CAS# 6131-98-2: No information available. Canada CAS# 526-94-3 is listed on Canada's DSL List. CAS# 526-94-3 is not listed on Canada's Ingredient Disclosure List. CAS# 6131-98-2 is not listed on Canada's Ingredient Disclosure List. US FEDERAL TSCA CAS# 526-94-3 is listed on the TSCA inventory. CAS# 6131-98-2 is not on the TSCA Inventory because it is a hydrate. It is considered to be listed if the CAS number for the anhydrous form is on the inventory (40CFR720.3(u)(2)). SECTION 16 - ADDITIONAL INFORMATION N/A

毒性和生态

毒理学数据: 急性毒性：大鼠经皮下LDLo：3gm/kg，除致死剂量外无详细说明； 小鼠经口LC50：4360mg/kg，除致死剂量外无详细说明； 小鼠经皮下LCLo：1gm/kg，肾，输尿管，膀胱-间质性肾炎； 兔子经皮下LDLo：1gm/kg，除致死剂量外无详细说明； 兔子经静脉LDLo：200mg/kg，行为-惊厥或癫痫，对肾，输尿管，膀胱引起其他变化； 生态学数据: 该物质对环境可能有危害，对水体应给予特别注意。 CHEMICAL IDENTIFICATION RTECS NUMBER : WW8225000 CHEMICAL NAME : Tartaric acid, monosodium salt CAS REGISTRY NUMBER : 526-94-3 LAST UPDATED : 199709 DATA ITEMS CITED : 7 MOLECULAR FORMULA : C4-H5-O6.Na MOLECULAR WEIGHT : 172.08 WISWESSER LINE NOTATION : QVYQYQVQ &-NA- HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 3 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 25,467,1925 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 4360 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : FAONAU FAO Nutrition Meetings Report Series. (Rome, Italy) No.?-57, 1948-77. Discontinued. Volume(issue)/page/year: 53A,512,1974 TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 1 gm/kg TOXIC EFFECTS : Kidney, Ureter, Bladder - interstitial nephritis REFERENCE : JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 25,467,1925 TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 1 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." (Leipzig, Ger. Dem. Rep.) Volume(issue)/page/year: 4,1289,1935 TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 200 mg/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold Kidney, Ureter, Bladder - other changes REFERENCE : JAPMA8 Journal of the American Pharmaceutical Association, Scientific Edition. (Washington, DC) V.29-49, 1940-60. For publisher information, see JPMSAE. Volume(issue)/page/year: 31,1,1942 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X8973 No. of Facilities: 30 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 447 (estimated) No. of Female Employees: 179 (estimated)

安全

• 个人防护装备: Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
• 危害码 (欧洲): Xn
• 安全声明 (欧洲): S22-S24/25
• 危险品运输编码: NONH for all modes of transport
• WGK德国: 2
• RTECS号: WW8225000
• 海关编码: 2918199090

合成路线

6381-59-5 ~% 526-94-3

文献：Lowry; Morgan Journal of the American Chemical Society, 1924 , vol. 46, p. 2192 Full Text View citing articles Show Details Docters van Leeuwen, J. Z. phys. Ch., 1897 , vol. 23, p. 34 - 38 Full Text Show Details Gmelin Handbook: K: MVol.6, 2.18.2.4, page 1217 - 1218

868-14-4 ~% 526-94-3

文献：Gmelin Handbook: K: MVol.5, 1.8.3, page 963 - 965

6381-59-5 6381-59-5 ~% 526-94-3 4958-46-7

文献：Gmelin Handbook: K: MVol.6, 2.16, page 1162 - 1164

上下游产品

上游产品  2
6381-59-5 868-14-4
下游产品  5
868-14-4 133-37-9 144-62-7 64-19-7
87-69-4

制备

1.将酒石酸溶于水，一部分溶液加入十水合碳酸钠中和，经过滤，将滤液加入剩余部分酒石酸溶液中，抽滤析出结晶，于室温下干燥，即得酒石酸氢钠。

2.由酒石酸与氢氧化钠或碳酸钠作用而制得。反应式为：

海关

海关编码	2918199090
中文概述	HS: 2918199090. 其他含醇基但不含其他含氧基羧酸（包括其酸酐、酰卤化物、过氧化物和过氧酸及该税号的衍生物）. 增值税率:17.0%. 退税率:9.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%
申报要素	品名, 成分含量, 用途
Summary	2918199090 other carboxylic acids with alcohol function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%