35788-27-3

• 常用中文名：b-D-Ribofuranuronamide,1-(6-amino-9H-purin-9-yl)-1-deoxy-N-methyl-
• 常用英文名：b-D-Ribofuranuronamide,1-(6-amino-9H-purin-9-yl)-1-deoxy-N-methyl-
• CAS号：35788-27-3
• 分子式：C₁₁H₁₄N₆O₄
• 分子量：294.26700
• 发布时间：2016-08-21 21:21:39
• 更新时间：2024-01-09 17:30:27

名称

• 英文名: 5'-n-methylcarboxamidoadenosine
• 英文别名: MEGA; 5'-N-methylcarboxamideadenosine; MECA; adenosine-5'-N-methyl uronamide

物化性质

• 密度: 1.98g/cm3
• 分子式: C₁₁H₁₄N₆O₄
• 分子量: 294.26700
• 精确质量: 294.10800
• PSA: 148.41000
• 折射率: 1.873
• 储存条件: 库房通风低温干燥,与食品原料分开存放

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : VJ2241000 CHEMICAL NAME : Ribofuranuronamide, 1-(6-amino-9H-purin-9-yl)-1-deoxy-N-methyl-, hemihydrate CAS REGISTRY NUMBER : 35788-27-3 LAST UPDATED : 199007 DATA ITEMS CITED : 2 MOLECULAR FORMULA : C11-H14-N6-O4.1/2H2-O MOLECULAR WEIGHT : 303.32 WISWESSER LINE NOTATION : T56 BN DN FN HNJ IZ D- BT5OTJ CQ DQ EVM1 &QH 1/2 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 20 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 23,313,1980 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 5 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 23,313,1980

安全

• 危害码 (欧洲): T+: Very toxic;
• 风险声明 (欧洲): 28
• 危险品运输编码: UN 2811 6.1/PG 2

合成路线

39491-51-5 ~43% 35788-27-3

文献：De Zwart, Maarten; Kourounakis, Angeliki; Kooijman, Huub; Spek, Anthony L.; Link, Regina; Von Frijtag Drabbe Kuenzel, Jacobien K.; IJzerman, Ad P. Journal of Medicinal Chemistry, 1999 , vol. 42, # 8 p. 1384 - 1392

89177-37-7 74-89-5 ~71% 35788-27-3

文献：Devine, Shane M.; Scammells, Peter J. Tetrahedron, 2008 , vol. 64, # 8 p. 1772 - 1777

19234-66-3 ~% 35788-27-3

文献：De Zwart, Maarten; Kourounakis, Angeliki; Kooijman, Huub; Spek, Anthony L.; Link, Regina; Von Frijtag Drabbe Kuenzel, Jacobien K.; IJzerman, Ad P. Journal of Medicinal Chemistry, 1999 , vol. 42, # 8 p. 1384 - 1392

159647-45-7 ~% 35788-27-3

文献：Umino; Yoshioka; Saitoh; Minakawa; Nakata; Matsuda Journal of Medicinal Chemistry, 2001 , vol. 44, # 2 p. 208 - 214

41110-75-2 74-89-5 ~% 35788-27-3

文献：Prasad, Raj Nandan; Bariana, Dilbagh S.; Fung, Anthony; Savic, Milica; Tietje, Karin; et al. Journal of Medicinal Chemistry, 1980 , vol. 23, # 3 p. 313 - 319

上下游产品

上游产品  4
39491-51-5 74-89-5 19234-66-3 41110-75-2
下游产品  1
152918-18-8