152918-18-8

• 常用中文名：匹利诺生
• 常用英文名：IB-MECA
• CAS号：152918-18-8
• 分子式：C₁₈H₁₉IN₆O₄
• 分子量：510.286
• 相关类别： 信号通路 G 蛋白偶联受体/G 蛋白 腺苷受体
• 发布时间：2018-03-23 08:00:00
• 更新时间：2024-01-11 11:36:57
• IB-MECA是一种腺苷A 3受体激动剂, EC50值为0.11 μM。

名称

• 中文名: 1-Deoxy-1-[6-[((3-Iodophenyl)methyl)amino]-9H-purin-9-yl]-N-methyl-β-D-ribofuranuronamide
• 英文名: (2S,3S,4R,5R)-3,4-dihydroxy-5-[6-[(3-iodophenyl)methylamino]purin-9-yl]-N-methyloxolane-2-carboxamide
• 中文别名: 匹利诺生
• 英文别名: UNII-30679UMI0N; Piclidenoson; (2S,3S,4R,5R)-3,4-Dihydroxy-5-{6-[(3-iodobenzyl)amino]-9H-purin-9-yl}-N-methyltetrahydro-2-furancarboxamide; IBMECA; (2S,3S,4R,5R)-3,4-Dihydroxy-5-{6-[(3-iodobenzyl)amino]-9H-purin-9-yl}-N-methyltetrahydrofuran-2-carboxamide (non-preferred name); CF 101; 3-IB-Meca; IB-MECA; CF101

物化性质

• 密度: 2.0±0.1 g/cm3
• 分子式: C₁₈H₁₉IN₆O₄
• 分子量: 510.286
• 精确质量: 510.051239
• PSA: 134.42000
• LogP: 2.08
• 折射率: 1.808
• 储存条件: 2-8°C，避光干燥密封

生物活性

• 描述: Piclidenoson (IB-MECA) 是一种腺苷A 3受体激动剂, EC50值为0.11 μM。
• 相关类别:
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 腺苷受体
  研究领域 >> 癌症
• 参考文献:

  [1]. Hofer M, et al. Agonist of the adenosine A3 receptor, IB-MECA, and inhibitor of cyclooxygenase-2, meloxicam, given alone or in a combination early after total body irradiation enhance survival of γ-irradiated mice. Radiat Environ Biophys. 2014 Mar;53(1):211-215.

  [2]. Abedi H, et al. Mitochondrial and caspase pathways are involved in the induction of apoptosis by IB-MECA in ovarian cancer cell lines. Tumour Biol. 2014 Nov;35(11):11027-11039.

  [3]. Shin Y, et al. Activation of Phosphoinositide Breakdown and Elevation of Intracellular Calcium in a Rat RBL-2H3 Mast Cell Line by Adenosine Analogs: Involvement of A(3)-Adenosine Receptors? Drug Dev Res. 1996 Sep 1;39(1):36-46.

安全

• 个人防护装备: Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
• 危险品运输编码: NONH for all modes of transport
• 海关编码: 2934999090

合成路线

3718-88-5 ~% 152918-18-8

文献：Journal of Medicinal Chemistry, , vol. 37, # 5 p. 636 - 646

104940-65-0 ~% 152918-18-8

文献：Journal of Medicinal Chemistry, , vol. 37, # 5 p. 636 - 646

152918-47-3 ~% 152918-18-8

文献：Journal of Medicinal Chemistry, , vol. 37, # 5 p. 636 - 646

696-41-3 ~% 152918-18-8

文献：Journal of Heterocyclic Chemistry, , vol. 37, # 2 p. 339 - 341

35788-27-3 ~% 152918-18-8

文献：Journal of Heterocyclic Chemistry, , vol. 37, # 2 p. 339 - 341

152918-48-4 ~% 152918-18-8

文献：Journal of Medicinal Chemistry, , vol. 37, # 5 p. 636 - 646

上下游产品

上游产品  5
3718-88-5 104940-65-0 152918-47-3 696-41-3
35788-27-3
下游产品  1
163042-96-4

海关

海关编码	2934999090
中文概述	2934999090. 其他杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途
Summary	2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%