56488-59-6

• 常用中文名：特丁贝罗
• 常用英文名：Terbufibrol
• CAS号：56488-59-6
• 分子式：C₂₀H₂₄O₅
• 分子量：344.40200
• 相关类别： 研究领域 代谢疾病
• 发布时间：2018-07-13 12:16:27
• 更新时间：2024-01-01 21:23:39
• Terbufibrol 在正常和高胆固醇血症雄性大鼠中,高效降低血清总胆固醇 (TC) 水平。

名称

• 中文名: 特丁贝罗
• 英文名: 4-[3-(4-tert-butylphenoxy)-2-hydroxypropoxy]benzoic acid
• 英文别名: 4'-(3-(4'-t-Butylphenoxy)-2-hydroxypropoxy)benzoic acid; 4-(3-(4-(1,1-Dimethylethyl)phenoxy)-2-hydroxypropoxy)benzoic acid; K-11,267; Terbufibrolum [INN-Latin]; BENZOIC ACID,p-(3-(p-tert-BUTYLPHENOXY)-2-HYDROXYPROPOXY); Terbufibrol; p-(3-(p-tert-Butylphenoxy)-2-hydroxypropoxy)benzoic acid; Terbufibrolum; Benzoic acid,4-(3-(4-(1,1-dimethylethyl)phenoxy)-2-hydroxypropoxy)

物化性质

• 密度: 1.179g/cm3
• 沸点: 524.1ºC at 760mmHg
• 分子式: C₂₀H₂₄O₅
• 分子量: 344.40200
• 闪点: 183.4ºC
• 精确质量: 344.16200
• PSA: 75.99000
• LogP: 3.50100
• 折射率: 1.566
• 储存条件: 库房通风低温干燥

生物活性

• 描述: Terbufibrol 在正常和高胆固醇血症雄性大鼠中,高效降低血清总胆固醇 (TC) 水平。
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 代谢疾病
• 体内研究: 特比布罗(20-200 mg/kg)在所有3种饮食中均可降低动物血清TC,但胆固醇降低的程度依次为胆固醇(HC)>高蛋白和脂肪饮食(HPF)> N(最大值。减少：分别为154％,80％和70％)。使用HPF饮食时,氯贝特(200 mg/kg)使TC降低最多28％,使用N饮食降低13％,但对HC饮食无效。消胆胺(400mg/kg /天)在HPF喂养的动物中无活性,但在HC喂养的动物中TC降低45％。使用HPF饮食烟酸(200 mg/kg)无效。替比福布降低喂食HPF饮食的动物的HDL,HDL-TC,LDL,LDL-TC和LDL-TC/PL。随着剂量增加,LDL-TC出现更大的降低。氯贝特(200 mg/kg)的主要作用是降低HDL和HDL-TC并增加LDL [1]。
• 动物实验: 狒狒[1] 18只狒狒（9只雄性，9只雌性）全程给予N-饮食，分成3组，每组6只，用特比布罗治疗8周，如下：第1组：对照;第2组：每天50毫克/千克;第3组：每天200毫克/千克。
• 参考文献:

  [1]. Howard AN, et al. The hypocholesterolemic effect of terbufibrol and other drugs in normal and hypercholesterolemic baboons. Atherosclerosis. 1979 Apr;32(4):367-80.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : DG4927000 CHEMICAL NAME : Benzoic acid, p-(3-(p-tert-butylphenoxy)-2-hydroxypropoxy)- CAS REGISTRY NUMBER : 56488-59-6 LAST UPDATED : 199612 DATA ITEMS CITED : 7 MOLECULAR FORMULA : C20-H24-O5 MOLECULAR WEIGHT : 344.44 WISWESSER LINE NOTATION : QVR DO1YQ1OR DX1&1&1 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 2400 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 4,140,1979 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 500 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 4,140,1979 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 2100 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 4,140,1979 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 335 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 4,140,1979 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 1800 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 4,140,1979 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - guinea pig DOSE/DURATION : 320 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 4,140,1979 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Mammal - species unspecified DOSE/DURATION : 5 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 4,140,1979

合成路线

60377-13-1 ~% 56488-59-6

文献：Klinge Pharma GmbH and Co Patent: DE2460689 , 1976 ; Chem.Abstr., 1979 , vol. 90, # 22564

99-76-3 ~% 56488-59-6

文献：Klinge Pharma GmbH and Co Patent: DE2460689 , 1976 ; Chem.Abstr., 1979 , vol. 90, # 22564

3101-60-8 ~% 56488-59-6

文献：Klinge Pharma GmbH and Co Patent: DE2460689 , 1976 ; Chem.Abstr., 1979 , vol. 90, # 22564

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