117545-11-6

• 常用中文名：比卡林
• 常用英文名：Bimakalim
• CAS号：117545-11-6
• 分子式：C₁₇H₁₄N₂O₂
• 分子量：278.30500
• 发布时间：2018-09-13 18:03:28
• 更新时间：2025-09-11 12:01:19

名称

• 中文名: 比卡林
• 英文名: 2,2-dimethyl-4-(2-oxopyridin-1-yl)chromene-6-carbonitrile
• 英文别名: 2,2-dimethyl-4-(2-oxopyridin-1(2H)-yl)-2H-chromene-6-carbonitrile; 4-(1,2-dihydro-2-oxo-1-pyridyl)-2,2-dimethyl-2H-1-benzopyran-6-carbonitrile; Bimakalimum; Bimakalimum [INN-Latin]; BIMAKALIM; Bimakalim [INN]; 6-cyano-4-(1,2-dihydro-2-oxopyrid-1-yl)-2,2-dimethylchromene; 2H-1-Benzopyran-6-carbonitrile,2,2-dimethyl-4-(2-oxo-1(2H)-pyridinyl); 6-cyano-2,2-dimethyl-4-(1H-2-oxopyrid-1-yl)-2H-chromene

物化性质

• 密度: 1.29g/cm3
• 沸点: 498.4ºC at 760mmHg
• 分子式: C₁₇H₁₄N₂O₂
• 分子量: 278.30500
• 闪点: 255.2ºC
• 精确质量: 278.10600
• PSA: 55.02000
• LogP: 2.78018
• 蒸汽压: 4.56E-10mmHg at 25°C
• 折射率: 1.651

合成路线

123595-75-5 ~87% 117545-11-6

文献：Bergmann; Gericke Journal of Medicinal Chemistry, 1990 , vol. 33, # 2 p. 492 - 504

33143-29-2 ~% 117545-11-6

文献：Buckle, Derek R.; Arch, Jonathon R. S.; Fenwick, Ashley E.; Houge-Frydrych, Catherine S. V.; Pinto, Ivan L.; et al. Journal of Medicinal Chemistry, 1990 , vol. 33, # 11 p. 3028 - 3034

127806-78-4 ~% 117545-11-6

文献：Bergmann; Gericke Journal of Medicinal Chemistry, 1990 , vol. 33, # 2 p. 492 - 504

142-08-5 65018-90-8 ~% 117545-11-6 123595-75-5

文献：Buckle, Derek R.; Arch, Jonathon R. S.; Fenwick, Ashley E.; Houge-Frydrych, Catherine S. V.; Pinto, Ivan L.; et al. Journal of Medicinal Chemistry, 1990 , vol. 33, # 11 p. 3028 - 3034

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