131926-99-3

• 常用中文名：兰索拉唑磺化物(兰索拉唑砜)
• 常用英文名：Lansoprazole Sulfone
• CAS号：131926-99-3
• 分子式：C₁₆H₁₄F₃N₃O₃S
• 分子量：385.361
• 相关类别： 信号通路 跨膜转运 质子泵
• 发布时间：2018-08-14 07:52:14
• 更新时间：2026-07-03 18:53:52
• 兰索拉唑砜(AG-1813)是一种口服活性和选择性的H+,K+-ATP酶抑制剂。兰索拉唑砜可通过抑制H+、K+-ATP酶来显著刺激胃酸分泌。兰索拉唑砜在十二指肠溃疡、胃溃疡、胃食管反流病和Zolinger-Ellison病中有潜在的应用[1][2]。

名称

• 中文名: 兰索拉唑磺酸盐
• 英文名: Lansoprazole Sulfone
• 中文别名: 右旋兰索拉唑杂质B; 兰索拉唑杂质II; 兰索拉唑磺酸盐(杂质B); 兰索拉唑相关物质A; 兰索拉唑砜,杂质B; 兰索拉唑杂质B(兰索拉唑砜); 兰素拉唑相关物质A; 兰索拉唑磺化物/兰索拉唑砜; 兰索拉唑杂质B; 兰索拉唑磺化物/兰索拉唑砜/兰索拉唑杂质; 2-[-[(3-甲基-4-(2,2,2-三氟乙氧基)- 2-吡啶基)甲基]磺酰基]苯并咪唑; 兰索拉唑欧洲药典杂质 B; 兰索拉唑杂质B 标准品; 兰索拉唑磺酰化物; 2-(((3-甲基-4-(2,2,2-三氟乙氧基)吡啶-2-基)甲基)磺酰基)-1H-苯并[D]咪唑; 2-[-[(3-甲基-4-(2,2,2-三氟乙氧基)-2-吡啶基)甲基]磺酰基]苯并咪唑; 兰索拉唑磺酸盐,10 MM DMSO 溶液; 兰索拉唑杂质 2; 兰索拉唑杂质Ⅱ; 兰索拉唑杂质B/杂质A; 兰索拉唑杂质2(兰索拉唑杂质B); 兰索拉唑相关化合物A; 兰索拉唑砜; 兰索拉唑磺化物; 兰索拉唑EP杂质B
• 英文别名: Lansoprazole Sulphone; 1H-BenziMidazole, 2-[[[3-Methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl]Methyl]sulfonyl]; Lansoprazole sulfone - Bio-X; Lansoprazole Impurity B/Impurity A; Lansoprazole Impurity B (Sulphone); Lansoprazole Related Compound A (25 mg) (2-[[[3-methyl-4-(2,2,2-triflouroethoxy)-2-pyridyl]methyl]sulfonyl]benzimidazole); Lansoprazole SulfoneDiscontinued See: L175026; Lansoprazole sulfoneQ: What is Lansoprazole sulfone Q: What is the CAS Number of Lansoprazole sulfone Q: What is the storage condition of Lansoprazole sulfone Q: What e the applications of Lansoprazole sulfone; Lansoprazole impurity 2/Lansoprazole Impurity B/Lansoprazole Sulfone/2-[[[3-methyl-4-(2,2,2-trifluoroethoxy)pyridin-2-yl]methyl]sulfonyl]-1H-benzimidazole; 2-[[3-methyl-4-(2,2,2-trifluoroethoxy)pyridin-2-yl]methylsulfonyl]-1H-benzimidazole; 2-[3-Methyl-4-(2,2,2-trifluoroethoxy)-2-pyridylmethylsulfonyl]-1H-benzimidazole; RC A)Cat No; Lansoprazole Related Compound A (or) imp B; Lansoprazole Impurity B（）; Lansoprazole Related Compound A; Lansoprazole Impurity B Lansoprazole Related Compound A; Lansoprazole related substance B; 2-(((3-methyl-4-(2,2,2-trifluoroethoxy)pyridin-2-yl)methyl)sulfonyl)-1H-benzo[d]imidazole; Lansoprazole Sulfone / Lansoprazole Impurity-B; LANSOPRAZOLE SULFONE; Lansoprazole Impurity Ⅱ/Lansoprazole sulfone; Lansoprazole IMpurity B; 2-({[3-Methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl]methyl}sulfonyl)-1H-benzimidazole; 2-[[[3-Methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl]methyl]sulfonyl]-1H-benzimidazole; Lansoprazole Impurity B/ Lansoprazole Related Compound A (Lansoprazole Sulfone); Lansoprazole-2; Lansoprazole Related CoMpound A; 2-[[[3-Methyl-4-(2,2,2-trifluoroethoxy)pyridin-2-yl]methyl]sulphonyl]-1H-benzimidazole (Lansoprazole; 2-[[[3-Methyl-4-(2,2,2-triflouroethoxy)-2-pyridyl]Methyl]sulfonyl]benziMidazole; Lansoprazole Impurity 2(Lansoprazole Impurity B); Dex-Lansoprazole Sulfone/Lansoprazole Impurity B /Lansoprazole Related Compound A; 2-[[[3-Methyl-4-(2,2,2-trifluoroeth; 2-[[4-(2,2,2-Trifluoroethoxy)-3-methylpyridine-2-yl]methylsulfonyl]-1H-benzoimidazole; Lansoprazole Impurity Ⅱ; Lansoprazole sulfone, 10 mM in DMSO; Lansoprazole IMpurity B (Lansoprazole Sulfone); 1H-Benzoimidazole-2-yl[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridyl]methyl] sulfone

物化性质

• 密度: 1.5±0.1 g/cm3
• 沸点: 555.6±60.0 °C at 760 mmHg
• 熔点: 207ºC(dec.)
• 分子式: C₁₆H₁₄F₃N₃O₃S
• 分子量: 385.361
• 闪点: 289.8±32.9 °C
• 精确质量: 385.070801
• PSA: 93.32000
• LogP: 4.46
• 蒸汽压: 0.0±1.5 mmHg at 25°C
• 折射率: 1.581
• 储存条件: 室温，干燥

生物活性

• 描述: 兰索拉唑砜(AG-1813)是一种口服活性和选择性的H+,K+-ATP酶抑制剂。兰索拉唑砜可通过抑制H+、K+-ATP酶来显著刺激胃酸分泌。兰索拉唑砜在十二指肠溃疡、胃溃疡、胃食管反流病和Zolinger-Ellison病中有潜在的应用[1][2]。
• 相关类别:
  研究领域 >> 代谢疾病
  信号通路 >> 跨膜转运 >> 质子泵
• 参考文献:

  [1]. Swamy G, et al. Crystal structure of lansoprazole sulfone[J]. Journal of Structural Chemistry, 2007, 48: 715-718.

  [2]. Karol MD, et al. Lansoprazole pharmacokinetics in subjects with various degrees of kidney function. Clin Pharmacol Ther. 1997 Apr;61(4):450-8.

安全

• 危险品运输编码: NONH for all modes of transport