25311-71-1

• 常用中文名：异柳磷
• 常用英文名：UNII:0514MAW53A
• CAS号：25311-71-1
• 分子式：C₁₅H₂₄NO₄PS
• 分子量：345.394
• 相关类别： 化学农药原药 杀虫剂 有机氯杀虫剂
• 发布时间：2018-04-06 08:00:00
• 更新时间：2024-01-12 12:44:07
• Isofenphos is a pesticide residue found in plant based food that may have acute health risks for consumers.

名称

• 中文名: 异柳磷
• 英文名: isofenphos
• 中文别名: 异丙胺磷; O-甲基-0-(邻异丙氧基羰基苯基)硫代磷酰酰胺
• 英文别名: pyrfon; 1-methylethyl 2-[[ethoxy[(1-methylethyl)amino]phosphinothioyl]oxy]benzoate; Amidocid; Amaze; O-ethyl O-(2-isopropoxycarbonyl-phenyl-isopropyl) phosphoramidothioate; ISOFENPHOS; Benzoic acid, 2-[[ethoxy[(1-methylethyl)amino]phosphinothioyl]oxy]-, 1-methylethyl ester; EINECS 246-814-1; Pryfon; (RS)-(O-ethyl O-2-isopropoxycarbonylphenyl isopropylphosphoramidothioate); [14C]-Isofenphos; propan-2-yl 2-{[ethoxy(propan-2-ylamino)phosphorothioyl]oxy}benzoate; Isopropyl 2-{[ethoxy(isopropylamino)phosphorothioyl]oxy}benzoate; discus; isopropyl (RS)-O-[ethoxy(isopropylamino)phosphinothioyl]salicylate; propan-2-yl 2-{[(Ξ)-P-ethoxy-N-propan-2-ylphosphoramidothioyl]oxy}benzoate; AMAZE(R); 40sd; MFCD00041805; OFTANOL; UNII:0514MAW53A; le-mat; O-ethyl-O-2-isopropoxycarbonylphenyl-N-isopropyl phosphoroamidothioate; isophenphos

物化性质

• 密度: 1.2±0.1 g/cm3
• 沸点: 411.5±47.0 °C at 760 mmHg
• 熔点: Less than -12ºC
• 分子式: C₁₅H₂₄NO₄PS
• 分子量: 345.394
• 闪点: 202.7±29.3 °C
• 精确质量: 345.116364
• PSA: 98.69000
• LogP: 4.12
• 蒸汽压: 0.0±1.0 mmHg at 25°C
• 折射率: 1.528
• 储存条件:

  0-6℃

• 分子结构:

  1、 摩尔折射率：91.89

  2、 摩尔体积（m³/mol）：298.3

  3、 等张比容（90.2K）：763.4

  4、 表面张力（dyne/cm）：42.9

  5、 极化率（10^-24cm³）：36.42

• 计算化学:

  1.疏水参数计算参考值（XlogP）:无

  2.氢键供体数量:1

  3.氢键受体数量:6

  4.可旋转化学键数量:9

  5.互变异构体数量:2

  6.拓扑分子极性表面积88.9

  7.重原子数量:22

  8.表面电荷:0

  9.复杂度:403

  10.同位素原子数量:0

  11.确定原子立构中心数量:0

  12.不确定原子立构中心数量:1

  13.确定化学键立构中心数量:0

  14.不确定化学键立构中心数量:0

  15.共价键单元数量:1

• 更多:

  1. 性状：亮黄色油状液体

  2. 密度（g/mL,25/4℃）：1.13

  3. 相对蒸汽密度（g/mL,空气=1）：未确定

  4. 熔点（ºC）：未确定

  5. 沸点（ºC,常压）：120

  6. 沸点（ºC,5.2kPa）：未确定

  7. 折射率：1.5165

  8. 闪点（ºC）：未确定

  9. 比旋光度（º）：未确定

  10. 自燃点或引燃温度（ºC）：未确定

  11. 蒸气压（kpa,20ºC）：未确定

  12. 饱和蒸气压（kPa,60ºC）：未确定

  13. 燃烧热（KJ/mol）：未确定

  14. 临界温度（ºC）：未确定

  15. 临界压力（KPa）：未确定

  16. 油水（辛醇/水）分配系数的对数值：未确定

  17. 爆炸上限（%,V/V）：未确定

  18. 爆炸下限（%,V/V）：未确定

  19. 溶解性：溶于丙酮、醇、醚、苯

毒性和生态

毒理学数据: 急性毒性：大鼠口经LD50：28 mg/kg；大鼠吸入LC50：144 mg/m3/4H；小鼠口经LD50：91300 ug/kg CHEMICAL IDENTIFICATION RTECS NUMBER : VO4395500 CHEMICAL NAME : Salicylic acid, isopropyl ester, O-ester with O-ethyl isopropylphosphoramidothioate CAS REGISTRY NUMBER : 25311-71-1 LAST UPDATED : 199710 DATA ITEMS CITED : 10 MOLECULAR FORMULA : C15-H24-N-O4-P-S MOLECULAR WEIGHT : 345.43 WISWESSER LINE NOTATION : 1Y1&OVR DOPS&O2&MY1&1 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 28 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 85ARAE "Agricultural Chemicals," Thomson, W.T., 4 vols., Fresno, CA, Thomson Publications, 1976/77 revision Volume(issue)/page/year: 1,118,1977 TYPE OF TEST : LC50 - Lethal concentration, 50 percent kill ROUTE OF EXPOSURE : Inhalation SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 144 mg/m3/4H TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 85JFAN "Agrochemicals Handbook," with updates, Hartley, D., and H. Kidd, eds., Nottingham, Royal Soc. of Chemistry, 1983-86 Volume(issue)/page/year: A236,1983 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Administration onto the skin SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 188 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : SPEADM Special Publication of the Entomological Society of America. (4603 Calvert Rd., College Park, MD 20740) Volume(issue)/page/year: 78-1,39,1978 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 91300 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 85DPAN "Wirksubstanzen der Pflanzenschutz und Schadlingsbekampfungsmittel," Perkow, W., Berlin, Verlag Paul Parey, 1971-1976 Volume(issue)/page/year: -,-,1971/1976 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Administration onto the skin SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 162 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : FMCHA2 Farm Chemicals Handbook. (Meister Pub., 37841 Euclid Ave., Willoughy, OH 44094) Volume(issue)/page/year: -,C173,1991 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Bird - chicken DOSE/DURATION : 3 mg/kg TOXIC EFFECTS : Behavioral - tremor Behavioral - muscle weakness Gastrointestinal - changes in structure or function of salivary glands REFERENCE : BECTA6 Bulletin of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1966- Volume(issue)/page/year: 33,386,1984 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Bird - quail DOSE/DURATION : 13 mg/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia Lungs, Thorax, or Respiration - dyspnea REFERENCE : EESADV Ecotoxicology and Environmental Safety. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1977- Volume(issue)/page/year: 8,551,1984 ** OTHER MULTIPLE DOSE TOXICITY DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 2240 mg/kg/8W-I TOXIC EFFECTS : Liver - other changes Biochemical - Metabolism (Intermediary) - other proteins REFERENCE : IJEBA6 Indian Journal of Experimental Biology. (Publications & Information Directorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963- Volume(issue)/page/year: 21,684,1983 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989

安全

• 符号: GHS02, GHS07
• 信号词: Danger
• 危害声明: H225-H302 + H312 + H332-H319-H412
• 警示性声明: P210-P273-P280-P305 + P351 + P338
• 个人防护装备: Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
• 危害码 (欧洲): T: Toxic;N: Dangerous for the environment;
• 风险声明 (欧洲): 24/25-50/53
• 安全声明 (欧洲): S36/37-S45-S60-S61
• 危险品运输编码: 3018
• RTECS号: VO4395500
• 包装等级: I
• 危险类别: 6.1(a)
• 海关编码: 2929909012

制备

由乙基硫磷酰二氯、水杨酸异丙酯、异丙胺经下列反应而得。将水杨酸异丙酯、乙基硫代磷酰二氯和催化剂投入反应釜，搅拌冷却至 10 ℃ 左右。缓慢加入一部分氢氧化钠溶液，反应半小时后再将其余的氢氧化钠溶液和异丙胺同时缓慢均匀加入。加毕后再继续反应2h。然后加水和溶剂，搅拌后静置分出下层废水，上层粗油经减压蒸馏即得乙基异柳磷原油。将乙基硫代磷酰二氯用甲基硫代磷酰二氯代替，采用相似工艺可制得甲基异柳磷。原料消耗定额：水杨酸 350kg /t、异丙醇 580kg /t、硫酸 340kg /t、甲醇 720kg /t、异丙胺 130kg /t、三氯硫磷 380kg /t。

海关

海关编码	2929909012
中文概述	2929909012 异柳磷、甲基异柳磷、丙胺氟磷等 退税率:0.0% 监管条件:S(进出口农药登记证明)
申报要素	品名, 成分含量, 用途
监管条件	S.进出口农药登记证明
Summary	2929909012 isopropyl 2-((ethoxy(isopropylamino)phosphorothioyl)oxy)benzoate