3044-42-6

• 常用中文名：2-((8S,9S,10R,11S,13S,14S)-11-羟基-10,13-二甲基-3-氧代-6,7,8,9,10,11,12,13,14,15-十氢-3H-环戊并[a]菲-17-基)-2-氧代乙基乙酸酯
• 常用英文名：21-Acetoxy-11beta -hydroxypregna-1,4,16-triene-3,20-dione
• CAS号：3044-42-6
• 分子式：C₂₃H₂₈O₅
• 分子量：384.46500
• 发布时间：2016-11-17 16:59:40
• 更新时间：2025-08-21 10:28:54

名称

• 中文名: 2-((8S,9S,10R,11S,13S,14S)-11-羟基-10,13-二甲基-3-氧代-6,7,8,9,10,11,12,13,14,15-十氢-3H-环戊并[a]菲-17-基)-2-氧代乙基乙酸酯
• 英文名: [2-[(8S,9S,10R,11S,13S,14S)-11-hydroxy-10,13-dimethyl-3-oxo-6,7,8,9,11,12,14,15-octahydrocyclopenta[a]phenanthren-17-yl]-2-oxoethyl] acetate
• 中文别名: 21-乙酰氧基-11β-羟基-1,4,16-孕甾三烯-3,20-二酮; 布地奈德杂质57; 布地奈德杂质15; 布地奈德杂质32; 2-((8S,9S,10R,11S,13S,14S)-11-羟基-10,13-二甲基-3-氧代-6,7,8,9,10,11,12,13,14,15 -十氢-3H-环戊并[A]菲-17-基)-2-氧代乙基乙酸酯; 布地奈德杂质3; [2-[(8S,9S,10R,11S,13S,14S)-11-羟基-10,13-二甲基-3-氧代; [2-[(8S,9S,10R,11S,13S,14S)-11-羟基-10,13-二甲基-3-氧代-6,7,8,9,11,12,14,15-八氢环戊烯并[A]菲-17-基]-2-氧代乙基]乙酸酯; 11Β,21- 二 羟 基 孕 甾 -1,4,16- 三烯 -3,20- 二酮 21- 乙酸酯; 布地奈德杂质 22; 三烯-3,20-二酮21-乙酸酯; 布地奈德杂质38(布地奈德中间体3); 布地奈德 1,4,14-三烯杂质
• 英文别名: 1,3-dimethyl-27-nitrosourea; Budesonide iMpurit 15; 21-Acetoxy-112-hydroxypregna-1,4,16-triene-3,20-dione; Intermediate of Budesonide; 11beta,21-dihydroxypregna-1,4,16-triene-3,20-dione 21-acetate; Budesonide triene; Budesonide Impurity 15; Budesonide Impurity 57; Budesonide Impurity 38 (Budesonide Intermediate 3); Budesonide Impurity 32; (11b)-21-(Acetyloxy)-11-hydroxypregna-1,4,16-triene-3,20-dione; 21-acetoxy-11β-hydroxypregna-1,4,16-triene-3,20-dione; Budesonide 1,4,16-Triene Impurity; (11|A)-11-hydroxy-3,20-dioxopregna-1,4,16-trien-21-yl acetate; 2-((8S,9S,10R,11S,13S,14S)-11-hydroxy-10,13-dimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15-decahydro-3H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl acetate; 21-Acetyloxy-11β-hydroxypregna-1,4,16-triene-3,20-dione; Deoxyprednisolone-16-Ene Acetate; [2-[(8S,9S,10R,11S,13S,14S)-11-Hydroxy-10,13-Dimethyl-3-Oxo-6,7,8,9,11,12,14,15-Octahydrocyclopenta[a]Phenanthren-17-Yl]-2-Oxoethyl] Acetate; Budesonide Impurity 3; Budesonide Impurity 3/(11)-21-(Acetyloxy)-11-hydroxypregna-1,4,16-triene-3,20-dione; 11β,21-dihydroxypregna-1,4,16-triene-3,20-dione 21-acetate; Pregna-1,4,16-triene-3,20-dione, 21-(acetyloxy)-11-hydroxy-, (11β); Pregna-1,4,16-triene-3,20-dione,21-(acetyloxy)-11-hydroxy-, (11b); Budesonide intermediate; Budesonide Impurity 22; 21-Acetoxy-11b-hydroxypregna-1,4,16-triene-3,20-dione; 21-acetoxy-11β-hydroxyl-1,4,16-pregnatriene-3,20-dione

物化性质

• 密度: 1.24g/cm3
• 沸点: 553.4ºC at 760mmHg
• 分子式: C₂₃H₂₈O₅
• 分子量: 384.46500
• 闪点: 189.9ºC
• 精确质量: 384.19400
• PSA: 80.67000
• LogP: 2.93360
• 折射率: 1.584
• 储存条件: 室温，干燥，密封

安全

• 危害码 (欧洲): Xi

合成路线

17652-24-3 ~88% 3044-42-6 3103-17-1

文献：Florida Agricultural and Mechanical University Patent: US4762919 A1, 1988 ;

17652-24-3 ~78% 3044-42-6

文献：Schering Aktiengesellschaft Patent: US4290963 A1, 1981 ;

125-10-0 ~% 3044-42-6

文献：Green, Michael J.; Tiberi, Robert L.; Friary, Richard; Lutsky, Barry N.; Berkenkoph, Joseph; et al. Journal of Medicinal Chemistry, 1982 , vol. 25, # 12 p. 1492 - 1495

6677-19-6 ~% 3044-42-6

文献：Green, Michael J.; Tiberi, Robert L.; Friary, Richard; Lutsky, Barry N.; Berkenkoph, Joseph; et al. Journal of Medicinal Chemistry, 1982 , vol. 25, # 12 p. 1492 - 1495

50-24-8 ~% 3044-42-6

文献：Taraporewala; Kim; Heiman; Lee Arzneimittel-Forschung/Drug Research, 1989 , vol. 39, # 1 p. 21 - 25

52628-64-5 ~% 3044-42-6

文献：Yoon, Kyoung-Jin; Khalil, Mounir A.; Kwon, Taesoo; Choi, Sun-Ju; Lee, Henry J. Steroids, 1995 , vol. 60, # 7 p. 515 - 521

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