125-10-0

• 常用中文名：醋酸泼尼松
• 常用英文名：d-Corlin
• CAS号：125-10-0
• 分子式：C₂₃H₂₈O₆
• 分子量：400.46
• 相关类别： 原料药 激素及调节内分泌功能类药 肾上腺皮质激素类药
• 发布时间：2018-02-07 08:00:00
• 更新时间：2026-07-01 17:26:21
• Prednisone acetate (Prednisone 21-acetate) 是泼尼松的醋酸盐形式,Prednisone acetate 是一种具有抗炎和免疫调节特性的糖皮质激素受体激动剂。

名称

• 中文名: 醋酸泼尼松
• 英文名: cortancyl
• 中文别名: 醋酸泼尼松(醋酸强的松、去氢可的松醋酸酯、乙酸去氢可的松、乙酸去氢肾上腺皮质激素、乙酸脱氢可的松); 乙腈中醋酸泼尼松; 醋酸泼尼松的原料药; 去氢可的松醋酸酯; 醋酸泼尼松(泼尼松醋酸酯)检测标准品; 醋酸泼尼松,10 MM DMSO 溶液; 醋酸泼尼松原料药厂商; 醋酸泼尼松原料药; 乙酸去氢可的松; 醋酸强的松; 泼尼松醋酸盐; 醋酸泼尼松 现货; 醋酸脱氢可的松; 醋酸泼尼松,PREDNISONEACETATE; 21-醋酸泼尼松; 乙酸脱氢可的松; 醋酸泼尼松(对照品); 醋酸泼尼松原粉; 醋酸泼尼; 泼尼松杂质6; 醋酸泼尼松原料粉; 甲醇中泼尼松醋酸酯(醋酸泼尼松)标准物质; 醋酸强的松原料药; 醋酸泼尼松原料; Prednisone Acetate 醋酸泼尼松; 泼尼松杂质E; 湖北醋酸泼尼松原料药; 泼尼松醋酸酯; 醋酸泼尼松纯标准品; 乙酸强的松; 醋酸去氢可的松; 17Α,21-二羟基-Δ1,4-孕甾二烯-3,11,20-三酮-21-醋酸酯,17Α,21-DIHYDROXY-1,4-PREGNADIENE-3,11,20-TRIONE-21-ACETATE; 醋酸强的松、强的松; 醋酸泼尼松溶液,100PPM; 醋酸去氢皮质素; 醋酸波尼松BP68; 17a,21-二羟基孕甾-1,4-二烯-3,11,20-三酮 21-醋酸酯; 泼尼松杂质E(醋酸泼尼松21); 醋酸泼尼松(标准品); 乙酸去氢肾上腺皮质激素
• 英文别名: δ-Cortelan; [2-[(8S,9S,10R,13S,14S,17R)-17-hydroxy-10,13-dimethyl-3,11-dioxo-6,7,8,9,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl]-2-oxo-ethyl] ethanoate; prednisone 21-acetate; 21-Acetoxy-17α-hydroxypregna-1,4-diene-3,11,20-trione; Prednisone acetate, Glucocorticoid; MFCD00200229; Prednisone 21-acetate; deltalone; 21-Acetoxy-17a-hydroxypregna-1,4-diene-3,11,20-trione (Prednisone Acetate); delta-corlin; EINECS 204-726-0; [2-[(8S,9S,10R,13S,14S,17R)-17-hydroxy-10,13-dimethyl-3,11-dioxo-6,7,8,9,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl]-2-oxoethyl] acetate; hot selling Prednisone 21-acetate; [2-[(8s,9s,10s,13s,14s,17r)-17-hydroxy-10,13-dimethyl-3,11-dioxo-6,7,8,9,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl]-2-oxo-ethyl] acetate; Prednisolone Impurity 32; ACETIC ACID 2-((8S,9S,10R,13S,14S,17R)-17-HYDROXY-10,13-DIMETHYL-3,11-DIOXO-6,7,8,9,10,11,12,13,14,15,16,17-DODECAHYDRO-3H-CYCLOPENTA[A]PHENANTHREN-17-YL)-2-OXO-ETHYL ESTER; d-Cortelan; Prednisone 21-acetate //BP; Prednisone 21-acetate / Dehydrocortisone acetate; Prendnisone acetate; Prednisone 21-acetat; Prednisone/ Prednisone Acetate; 21-(Acetyloxy)-17-hydroxy-pregna-1,4-diene-3,11,20-trione; Cortancyl (Prednisone 21-acetate); 17α,21-Dihydroxypregna-1,4-diene-3,11,20-trioneacetate; 17-Hydroxy-3,11,20-trioxopregna-1,4-dien-21-yl acetate; acetic acid [2-(17-hydroxy-10,13-dimethyl-3,11-dioxo-6,7,8,9,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl)-2-oxoethyl] ester; δ-Corlin; 1-DEHYDROCORTISONE ACETATE; 1-Cortisone 21-Acetate; 4-diene-3,11,20-trione,17,21-dihydroxy-pregna-21-acetate; 1,4-PREGNADIEN-17,21-DIOL-3,11,20-TRIONE 21-ACETATE; 17,21-Dihydroxypregna-1,4-diene-3,11,20-trione-21-acetate; Alitretinoin Impurity 22; Prednisone acetate, 10 mM in DMSO; Prednisone Impurity E (Prednisone 21-Acetate); 17 ALPHA,21-DIHYDROXYPREGNA-1,4-DIENE-3,11,20-TRIONE-21-ACETATE; 1,4-PREGNADIEN-17ALPHA,21-DIOL-3,11,20-TRIONE 21-ACETATE; delcortin; Prednisone Impurity E; acetic acid [2-[(8S,9S,10R,13S,14S,17R)-17-hydroxy-3,11-diketo-10,13-dimethyl-6,7,8,9,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl]-2-keto-ethyl] ester; delta’-dehydrocortisoneacetate; Dehydrocortisone acetate; PREDNISONE ACETATE; nisone; Prednisone Impurity 6; Pregna-1,4-diene-3,11,20-trione,21-(acetyloxy)-17-hydroxy; 11,20-trione,21-(acetyloxy)-17-hydroxy-pregna-4-diene-3; Ferr; Cblconin

物化性质

• 密度: 1.3±0.1 g/cm3
• 沸点: 582.0±50.0 °C at 760 mmHg
• 熔点: 240-242°C (dec.)
• 分子式: C₂₃H₂₈O₆
• 分子量: 400.46
• 闪点: 200.2±23.6 °C
• 精确质量: 400.188599
• PSA: 97.74000
• LogP: 2.66
• 蒸汽压: 0.0±3.7 mmHg at 25°C
• 折射率: 1.580
• 储存条件: Refrigerator
• 分子结构:

  1、 摩尔折射率：103.66

  2、 摩尔体积（cm³/mol）：311.5

  3、 等张比容（90.2K）：845.7

  4、 表面张力（dyne/cm）：54.3

  5、 极化率（10-24cm3）：41.09

• 计算化学:

  1.疏水参数计算参考值（XlogP）:无

  2.氢键供体数量:1

  3.氢键受体数量:6

  4.可旋转化学键数量:4

  5.互变异构体数量:18

  6.拓扑分子极性表面积97.7

  7.重原子数量:29

  8.表面电荷:0

  9.复杂度:869

  10.同位素原子数量:0

  11.确定原子立构中心数量:6

  12.不确定原子立构中心数量:0

  13.确定化学键立构中心数量:0

  14.不确定化学键立构中心数量:0

  15.共价键单元数量:1

生物活性

• 描述: Prednisone acetate (Prednisone 21-acetate) 是泼尼松的醋酸盐形式,Prednisone acetate 是一种具有抗炎和免疫调节特性的糖皮质激素受体激动剂。
• 相关类别:
  研究领域 >> 炎症/免疫
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 糖皮质激素受体
• 靶点:

  glucocorticoid receptor[1]

• 参考文献:

  [1]. Prednisolone acetate

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : TU4154085 CHEMICAL NAME : Pregna-1,4-diene-3,11,20-trione, 17,21-dihydroxy-, 21-acetate CAS REGISTRY NUMBER : 125-10-0 BEILSTEIN REFERENCE NO. : 2342061 LAST UPDATED : 199612 DATA ITEMS CITED : 3 MOLECULAR FORMULA : C23-H28-O6 MOLECULAR WEIGHT : 400.51 WISWESSER LINE NOTATION : L E5 B666 CV OV AHTTT&J A1 E1 FV1OV1 FQ HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intramuscular DOSE : 330 mg/kg SEX/DURATION : female 10 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Embryo or Fetus - fetal death Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue) REFERENCE : TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 56,23,1980 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intramuscular DOSE : 135 mg/kg SEX/DURATION : female 10 day(s) after conception TOXIC EFFECTS : Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) REFERENCE : TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 56,23,1980 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X3270 No. of Facilities: 18 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 1045 (estimated) No. of Female Employees: 1045 (estimated)

安全

• 危害码 (欧洲): Xi
• 风险声明 (欧洲): R20/21/22:Harmful by inhalation, in contact with skin and if swallowed . R36/37/38:Irritating to eyes, respiratory system and skin .
• 安全声明 (欧洲): S26-S36/37/39
• 海关编码: 2937210000

合成路线

52-21-1 ~99% 125-10-0

文献：Lapitskaya, Margarita A.; Vasiljeva, Ljudmila L.; Pivnitsky, Kasimir K. Mendeleev Communications, 2008 , vol. 18, # 6 p. 309 - 311

50-24-8 ~% 125-10-0

文献：Journal of the American Chemical Society, , vol. 77, p. 4781,4783

28449-43-6 ~% 125-10-0

文献：Journal of the American Chemical Society, , vol. 77, p. 4436

50-04-4 ~% 125-10-0

文献：Helvetica Chimica Acta, , vol. 39, p. 734,741 Recueil des Travaux Chimiques des Pays-Bas, , vol. 75, p. 475,480

53-03-2 108-24-7 ~% 125-10-0

文献：Heterocyclic Communications, , vol. 9, # 6 p. 575 - 578

52-21-1 ~% 898-84-0 125-10-0

文献：Journal of Pharmaceutical Sciences, , vol. 72, # 1 p. 30 - 35

上下游产品

上游产品  6
52-21-1 50-24-8 28449-43-6 50-04-4
53-03-2 108-24-7
下游产品  3
3044-42-6 17652-24-3 53-03-2

制备

【方法一】
醋酸可的松经二氧化硒脱氢而得。

海关

海关编码	2937210000