1132832-75-7

• 常用中文名：(5-溴-2-甲基苯基)-(5-(4-氟苯基)-2-噻吩基)甲酮
• 常用英文名：(5-Bromo-2-methylphenyl)[5-(4-fluorophenyl)-2-thienyl]methanone
• CAS号：1132832-75-7
• 分子式：C₁₈H₁₂BrFOS
• 分子量：375.255
• 发布时间：2018-12-28 18:03:27
• 更新时间：2026-08-02 19:02:11
• 医药中间体，用于生产抗糖尿病类药物卡格列净。
  

名称

• 中文名: (5-溴-2-甲基苯基)(5-(4-氟苯基)-2-噻吩)甲酮
• 英文名: (5-Bromo-2-methylphenyl)[5-(4-fluorophenyl)-2-thienyl]methanone
• 中文别名: 5-溴-2-甲基苯基)5-(对氟苯基)噻吩基甲酮; 卡格列净杂质B; (5-溴-2-甲基苯基)(5-(对氟苯基)噻吩-2-基)甲酮; C-5溴化物; 2-(5-溴-2-甲基苯甲酰基)-5-(4-氟苯基)噻吩; 卡格列净 中间体 KG-1; 溴-2-甲基苯基)(5-(4-氟苯基)-2-噻吩)甲酮; (5-溴-2-甲基苯基)(5-(4-氟苯基)噻吩-2-基)甲酮; 坎格列净中间体2; C-5溴化物/(5-溴-2-甲基苯基)5-(对氟苯基)噻吩基甲酮; (5-溴-2-甲基苯基)[5-(对氟苯基)噻吩-2-基]甲酮; 溴代酮; 卡格列净中间体(C-5溴化物); (5-溴-2-甲基苯基)-(5-(4-氟苯基)-2-噻吩基)甲酮(5-BROMO-2-METHYLPHENYL)(5-(4-FLUOROPHENYL)THIOPHEN-2-YL)METHANONE; 卡格列净; 坎格列嗪杂质 B
• 英文别名: Canagliflozin INT1; (5-bromo-2-methylphenyl)[5-(4-flurophenyl)-2-thienyl]-methanone; Methanone,(5-bromo-2-methylphenyl)(4-methoxyphenyl); (5-Bromo-2-methylphenyl)[5-(4-fluorophenyl)-2-thienyl]; (2R,3S,4S,5R)-2-((S)-1,2-dihydroxyethyl)-5-(3-((5-(4-fluorophenyl)thiophen-2-yl)methyl)-4-methylphenyl)tetrahydrofuran-3,4-diol; Methanone, (5-Bromo-2-methylphenyl)[5-(4-fluorophenyl)-2-thi; Canagliflozin Intermediate KG-1; (5-bromo-2-methylphenyl)(5-(4-fluorophenyl)-2-thienyl)methanone; (5-bromo-2-methyl-phenyl)-[5-(4-fluoro-phenyl)-thiophen-2-yl]-methanone; (5-broMo-2-Methylphenyl)(5-(4-fluorophenyl)thiophen-2-yl)Methanone; CAS NO.:1132-7 Canagliflozin INT1; 1-[3-Chloro-5-[[4-(4-chlorothiophen-2-yl)-5-(4-cyclohexylpiperazin-1-yl)thiazol-2-yl]cbamoyl]-2-pyridyl]piperidine-4-cboxylic acid (Intermediate of Avatrombopag maleate); Canagliflozin iMpurity B; (5-Bromo-2-methylphenyl) - (5- (4-fluorophenyl) -2-thienyl) ketone; (5-Bromo-2-methyl-phenyl)-(4-methoxy-phenyl)-methanone; (5-BROMO-2-METHYLPHENYL)(5-(4-FLUOROPHENYL)THIOPHEN-2-YL)METHA; (5-bromo-2-methylphenyl) (5-(4-fluorophenyl)-2-thiophene) methylone; 2-(5-BroMo-2-Methylbenzoyl)-5-(4-fluorophenyl)thiophene; (5-broMo-2-Methylphenyl)[5-(4-fluorophenyl)-2-thienyl]- Methanone; (5-Bromo-2-methylphenyl) (5-(4-Fluorinhenyl)-2-Thiophene) Methrone; 5-Bromo-2-methyl-4'methoxybenzophenone; (5-bromo-2-methylph; Methanone, (5-BroMo-2-Methylphenyl)[5-(4-fluorophenyl)-2-thienyl]; Capagliflozin impurity 65

物化性质

• 密度: 1.4±0.1 g/cm3
• 沸点: 476.0±45.0 °C at 760 mmHg
• 熔点: 121-122 °C
• 分子式: C₁₈H₁₂BrFOS
• 分子量: 375.255
• 闪点: 241.7±28.7 °C
• 精确质量: 373.977631
• PSA: 45.31000
• LogP: 6.03
• 蒸汽压: 0.0±1.2 mmHg at 25°C
• 折射率: 1.625
• 储存条件: 2-8°C， 避光， 干燥， 密封

安全

• 危害码 (欧洲): Xi
• 海关编码: 2934999090

合成路线

58861-48-6 21900-41-4 ~84% 1132832-75-7

文献：Nomura, Sumihiro; Sakamaki, Shigeki; Hongu, Mitsuya; Kawanishi, Eiji; Koga, Yuichi; Sakamoto, Toshiaki; Yamamoto, Yasuo; Ueta, Kiichiro; Kimata, Hirotaka; Nakayama, Keiko; Tsuda-Tsukimoto, Minoru Journal of Medicinal Chemistry, 2010 , vol. 53, # 17 p. 6355 - 6360

460-00-4 ~% 1132832-75-7

文献：TFCHEM; DELIENCOURT-GODEFROY, Geraldine; LOPES, Lenaig Patent: WO2012/160218 A1, 2012 ; WO 2012/160218 A1

79669-49-1 ~% 1132832-75-7

文献：TFCHEM; DELIENCOURT-GODEFROY, Geraldine; LOPES, Lenaig Patent: WO2012/160218 A1, 2012 ; WO 2012/160218 A1

上下游产品

上游产品  4
58861-48-6 21900-41-4 460-00-4 79669-49-1
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海关

海关编码	2934999090
中文概述	2934999090. 其他杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途
Summary	2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%