1030825-20-7

• 常用中文名：2-(2-甲基-5-溴苄基)-5-(4-氟苯)噻吩
• 常用英文名：2-(5-bromo-2-methylbenzyl)-5-(4-fluorophenyl)thiophene
• CAS号：1030825-20-7
• 分子式：C₁₈H₁₄BrFS
• 分子量：361.271
• 相关类别： 医药中间体 杂环化合物 噻吩类化合物
• 发布时间：2018-12-25 16:46:36
• 更新时间：2026-06-30 12:25:49

名称

• 中文名: 2-(2-甲基-5-溴苄基)-5-(4-氟苯)噻吩
• 英文名: 2-[(5-bromo-2-methylphenyl)methyl]-5-(4-fluorophenyl)thiophene
• 中文别名: 卡格列净INT; 2-(5-溴-2-甲基苯甲基)-5-(4-氟苯基)噻吩; 2-(4-氟苯基)-5-((5-溴-2-甲基苯基)甲基)噻吩; 坎格列净 中间体4; 卡格列净杂质; 2-(5-溴-2-甲基-苄基)-5 -(4-氟-苯基)-噻吩; C-6溴化物/2-[(5-溴-2-甲基苯基)甲基]-5-(4-氟苯基)噻吩; C-6溴化物; 2-(5-溴-2-甲基苯基)-5-(4-氟苯基)噻吩; 卡格列净杂质52; 坎格列净中间体1; 2-(4-氟苯基)-5-(5-溴-2-甲基苯基)甲基噻吩; 2-[(5-溴-2-甲基苯基)甲基]-5-(4-氟苯基)噻吩; 2-(2-甲基-5-溴苄基)-5-(4-氟苯)噻吩(坎格列净中间体); 2-(2-甲基-5-溴苄基-5-(4-氟苯))噻吩 (卡格列净中间体); 2-(5-溴-2-甲基苯基)-5-(4-氟苯)噻吩; 卡那列净杂质69; 2-(2-甲基-5-溴苄基)-5-(4-氟苯)噻吩(卡格列净杂质); 卡格列净中间体(C-6溴化物); 坎格列净中间体; 2-(4-氟苯基)-5-[(5-溴-2-甲基苯基)甲基]噻吩2-(5-BROMO-2-METHYLBENZYL)-5-(4-FLUOROPHENYL)THIOPHENE; 2-(5-溴-2-甲基苯甲基)-5-(4-氟苯基)噻吩*5; 2-(4-氟苯)-5-(5-溴-2-甲基苄基)噻吩; 2-(甲基-5-溴卞基)-5-(4-氟苯)噻吩; 卡格列净中间体4; 3-(2-甲基-5-溴苄基)-5-(4-氟苯)噻吩
• 英文别名: )-5-(4-fL; 2-((5-bromo-2-methylphenyl)methyl)-5-(4-fluorophenyl)thiophe; Canagliflozin Impurity 52; Canagliflozin Intermediate2; Canagliflozin INT4; 2-(5-Bromo-2-methylbenzyl)-5-(4-fluorophenyl]thiophene (Canagliflozin Impurity); 2-((5-bromo-2-methylphenyl)methyl)-5-(4-fluorophenyl)thiophene; Canagliflozin Bromo Impurity; 2-(4-fluorophenyl)-5-[(5-bromo-2-methylphenyl)methyl]thiophene; Canagliflozin Bromo Imp; 2-(5-Bromo-2-methyL; canagliflozin impurities1; 1030-7 2-(5-BroMo-2-Methylbenzyl)-5-(4-fluorophenyl)thiophene; 2-[(5-Bromo-2-methylphenyl)methyl]-5-(4-fluorophenyl)thiophene; CanagliflozinINT; 2-(5-bromo-2-methyl-benzyl-(5-fluorophenyl)thiophene; 2-(5-Bromo-2-methylbenzoyl)-5-(4-fluorophenyl)thio; canagliflozin impurities603; 2-(2-Methyl-5-bromobenzyl)-5-(4-fluorophenyl)thiophene; Canagliflozin-19; 2-(5-Bromo-2- Methylbenzyl)-5-(4-fIuorophenyl) t; 2-(5-Bromo-2-methylbenzyl)-5-(4-fluorophenyl)thiophene; Thiophene, 2-[(5-broMo-2-Methylphenyl)Methyl]-5-(4-fluorophenyl); 2-(5-BroMo-2-Methylbenzyl)-5-(4-fluorophenyl)thiophene 1030-7; Methyl-2-ethoxy-1-((2'-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)biphenyl-4-yl)methyl)-1H-benzo[d]imidazole-7-cboxylate (Intermediate of Azilstan ); Canagliflozin Intermediate II; Kagliflozin impurity 24; Canagliflozin intermediate; Canagliflozin impurity CQ: What is Canagliflozin impurity C Q: What is the CAS Number of Canagliflozin impurity C Q: What is the storage condition of Canagliflozin impurity C; CAGLIFLOZIN IMPURITY C; 2-(5-BroMo-2-Methylbenzyl)-5-(4-fluorophenyl)thiophene; Canogliflozin; 2- (2-methyl-5-bromobenzyl) -5- (4-fluorobenzene) thiophene

物化性质

• 密度: 1.4±0.1 g/cm3
• 沸点: 438.3±40.0 °C at 760 mmHg
• 熔点: 103 °C
• 分子式: C₁₈H₁₄BrFS
• 分子量: 361.271
• 闪点: 218.9±27.3 °C
• 精确质量: 359.998352
• PSA: 28.24000
• LogP: 6.93
• 外观性状: 固体;White to Light yellow powder to crystal
• 蒸汽压: 0.0±1.0 mmHg at 25°C
• 折射率: 1.617
• 储存条件: 室温，干燥，密封

安全

• 危害码 (欧洲): Xi
• 海关编码: 2934999090

合成路线

1132832-75-7 ~76% 1030825-20-7

文献：Nomura, Sumihiro; Sakamaki, Shigeki; Hongu, Mitsuya; Kawanishi, Eiji; Koga, Yuichi; Sakamoto, Toshiaki; Yamamoto, Yasuo; Ueta, Kiichiro; Kimata, Hirotaka; Nakayama, Keiko; Tsuda-Tsukimoto, Minoru Journal of Medicinal Chemistry, 2010 , vol. 53, # 17 p. 6355 - 6360

460-00-4 ~% 1030825-20-7

文献：WO2012/160218 A1, ; WO 2012/160218 A1

79669-49-1 ~% 1030825-20-7

文献：WO2012/160218 A1, ; WO 2012/160218 A1

58861-48-6 ~% 1030825-20-7

文献：WO2012/160218 A1, ; WO 2012/160218 A1

21900-41-4 ~% 1030825-20-7

文献：WO2012/160218 A1, ; WO 2012/160218 A1

上下游产品

上游产品  5
1132832-75-7 460-00-4 79669-49-1 58861-48-6
21900-41-4
下游产品  1
898566-17-1

海关

海关编码	2934999090
中文概述	2934999090. 其他杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途
Summary	2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%