乐卡地平

• 常用名: 乐卡地平
• 英文名: Lercanidipine
• CAS号: 100427-26-7
• 分子量: 611.727
• 密度: 1.2±0.1 g/cm3
• 沸点: 712.5±60.0 °C at 760 mmHg
• 分子式: C₃₆H₄₁N₃O₆
• 熔点: 118-120ºC
• 闪点: 384.7±32.9 °C

乐卡地平用途

Lercanidipine是钙离子通道阻断剂。

乐卡地平名称

• 中文名: 乐卡地平
• 英文名: 5-O-[1-[3,3-diphenylpropyl(methyl)amino]-2-methylpropan-2-yl] 3-O-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
• 中文别名: 1,4-双氢-2,6-二甲基-4-(3-硝基苯基)-3,5-吡啶二羧酸 2-[(3,3-二苯丙基)甲氨基]-1,1-二甲基乙基甲酯

乐卡地平生物活性

• 描述: Lercanidipine是钙离子通道阻断剂。
• 相关类别:
  信号通路 >> 跨膜转运 >> 钙通道
  研究领域 >> 心血管疾病
• 参考文献:

  [1]. Barrios, V., et al., Lercanidipine is an effective and well tolerated antihypertensive drug regardless the cardiovascular risk profile: The LAURA study. Int J Clin Pract, 2006. 60(11): p. 1364-70.

  [2]. Burnier, M., M. Pruijm, and G. Wuerzner, Treatment of essential hypertension with calcium channel blockers: what is the place of lercanidipine? Expert Opin Drug Metab Toxicol, 2009. 5(8): p. 981-7.

乐卡地平物理化学性质

• 密度: 1.2±0.1 g/cm3
• 沸点: 712.5±60.0 °C at 760 mmHg
• 熔点: 118-120ºC
• 分子式: C₃₆H₄₁N₃O₆
• 分子量: 611.727
• 闪点: 384.7±32.9 °C
• 精确质量: 611.299561
• PSA: 113.69000
• LogP: 8.04
• InChIKey: ZDXUKAKRHYTAKV-UHFFFAOYSA-N
• SMILES: COC(=O)C1=C(C)NC(C)=C(C(=O)OC(C)(C)CN(C)CCC(c2ccccc2)c2ccccc2)C1c1cccc([N+](=O)[O-])c1
• 外观性状: 白色至淡黄色固体
• 蒸汽压: 0.0±2.3 mmHg at 25°C
• 折射率: 1.580

乐卡地平安全信息

• 海关编码: 2942000000

乐卡地平海关

• 海关编码: 2942000000

乐卡地平靶点实验

查看更多实验

实验名称：qHTS to identify inhibitors of the New Delhi Metallo-beta-lactamase (NDM): assay vali... 来源：NCGC External Id：adst_MBL_Abs_LOPAC_o1

实验名称：Primary qHTS for small molecule stabilizers of the endoplasmic reticulum resident pro... 来源：NCGC 靶标：N/A External Id：SERCaMPGLuc-p1-antagonist

实验名称：Compound was evaluated for inhibition of rat Gabra1 in an in vitro assay with cellula... 来源：ChEMBL 靶标：Gamma-aminobutyric acid receptor subunit alpha-1 External Id：CHEMBL5291801

实验名称：Primary qHTS assay for inhibitors of alpha-synuclein gene (SNCA) expression 来源：NCGC External Id：SNCA-p-activity-luciferase

实验名称：qHTS Validation Assay for Inhibitors of Ubiquitin-specific Protease USP2a Using CHOP2... 来源：NCGC 靶标：ubiquitin carboxyl-terminal hydrolase 2 isoform a [Homo sapiens] External Id：UBCH001

实验名称：Binding affinity towards rat Gabra1 in an in vitro assay with cellular components mea... 来源：ChEMBL 靶标：Gamma-aminobutyric acid receptor subunit alpha-1 External Id：CHEMBL5291798

实验名称：Binding affinity towards human ESR1 in an in vitro cell free assay (NIBR assay) measu... 来源：ChEMBL 靶标：Estrogen receptor External Id：CHEMBL5291791

实验名称：Rescue cell viability in cybrid cells with a genetic mutation in complex 1 of the mit... 来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School 靶标：N/A External Id：HMS1315

实验名称：Binding affinity towards human DRD2 in an in vitro assay with cellular components mea... 来源：ChEMBL 靶标：D(2) dopamine receptor External Id：CHEMBL5291781

实验名称：Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resol... 来源：ChEMBL 靶标：D(1A) dopamine receptor External Id：CHEMBL5291777

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乐卡地平英文别名

• 1-[(3,3-diphenylpropyl)(methyl)amino]-2-methylpropan-2-yl methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
• 3-O-[1-[3,3-diphenylpropyl(methyl)amino]-2-methylpropan-2-yl] 5-O-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
• 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic Acid 2-[(3,3-Diphenylpropyl)methylamino]-1,1-dimethylethyl Methyl Ester
• lercarnidipine
• 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 2-[(3,3-diphenylpropyl)methylamino]-1,1-dimethylethyl methyl ester
• methyl 1,1,N-trimethyl-N-(3,3-diphenylpropyl)-2-aminoethyl 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-pyridine-3,5-dicarboxylate
• masnidipine
• Methyl 1,1-Dimethyl-2-[N-(3,3-diphenylpropyl)-N-methylamino]ethyl 2,6-Dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
• 1-[(3,3-Diphenylpropyl)(methyl)amino]-2-methyl-2-propanyl methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydro-3,5-pyridinedicarboxylate
• Lercanidipine [INN]
• UNII:V7XTJ4R0BH
• Lercanil (TN)
• (±)-2-((3,3-diphenylpropyl)(methyl)amino)-1,1-dimethylethyl methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
• REC 15-2375
• MFCD00867978
• UNII-V7XTJ4R0BH
• 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinecarboxylic acid 2-[(3,3-diphenylpropyl)methylamino]-1,1-dimethylethyl methyl ester
• Lercanidipine