A7132

• 常用名: A7132
• 英文名: A7132
• CAS号: 100490-21-9
• 分子量: 386.35200
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₉H₁₆F₂N₄O₃
• 熔点: N/A
• 闪点: N/A

A7132用途

A7132 是一种有效的广谱抗菌剂。

A7132名称

• 中文名: 6-氟-1-(4-氟苯基)-4-氧代-7-(哌嗪-1-基)-1,4-二氢-1,8-萘啶-3-羧酸
• 英文名: 6-fluoro-1-(4-fluorophenyl)-4-oxo-7-piperazin-1-yl-1,8-naphthyridine-3-carboxylic acid

A7132生物活性

• 描述: A7132 是一种有效的广谱抗菌剂。
• 相关类别:
  信号通路 >> 抗感染 >> 细菌
  研究领域 >> 感染
• 靶点实验:

  Antibacterial[1]

• 体外研究: A7132(化合物31)显示出对金黄色葡萄球菌NCTC 10649,大肠杆菌Juhl和铜绿假单胞菌5007的良好口服活性,MIC分别为0.25,0.05和0.39μg/ mL [1]。
• 参考文献:

  [1]. Chu DT, et al. Synthesis and structure-activity relationships of new arylfluoronaphthyridine antibacterialagents. J Med Chem. 1986 Nov;29(11):2363-9.

A7132物理化学性质

• 分子式: C₁₉H₁₆F₂N₄O₃
• 分子量: 386.35200
• 精确质量: 386.11900
• PSA: 87.46000
• LogP: 2.16550
• InChIKey: ROMLGDPRVIVYSV-UHFFFAOYSA-N
• SMILES: O=C(O)c1cn(-c2ccc(F)cc2)c2nc(N3CCNCC3)c(F)cc2c1=O
• 储存条件: -20°C，密闭，干燥

A7132靶点实验

查看更多实验

实验名称：In vivo dose(sc) inhibiting systemic infections caused by Pseudomonas aeruginosa 5007... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL716198

实验名称：In vivo dose(sc) inhibiting systemic infections caused by Staphylococcus aureus NCTC ... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL716200

实验名称：In vitro antibacterial activity against Streptococcus faecium ATCC 8043 来源：ChEMBL 靶标：Enterococcus faecium External Id：CHEMBL813856

实验名称：In vivo antibacterial activity against systemic infection caused by Escherichia coli ... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL723773

实验名称：In vitro antibacterial activity against Enterobacter aerogenes ATCC 13048 来源：ChEMBL 靶标：Klebsiella aerogenes External Id：CHEMBL678425

实验名称：In vivo antibacterial activity against systemic infection caused by Pseudomonas aerug... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL723775

实验名称：In vivo antibacterial activity against systemic infection caused by Staphylococcus au... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL723919

实验名称：In vitro antibacterial activity against Klebsiella pneumoniae 8045 来源：ChEMBL 靶标：Klebsiella pneumoniae External Id：CHEMBL704187

实验名称：In vitro antibacterial activity against Escherichia coli (A 15119) 来源：ChEMBL 靶标：Escherichia coli External Id：CHEMBL671304

实验名称：In vitro antibacterial activity against Pseudomonas aeruginosa (A 9843) 来源：ChEMBL 靶标：Pseudomonas aeruginosa External Id：CHEMBL754842

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A7132英文别名

• 1-p-fluorophenyl-6-fluoro-1,4-dihydro-4-oxo-7(1-piperazinyl)-1,8-naphthyridine-3-carboxylic acid
• 6-fluoro-1-(4-fluorophenyl)-4-oxo-7-(piperazin-1-yl)-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid
• sarafloxacin
• A7132