苏木酮A

• 常用名: 苏木酮A
• 英文名: Sappanone A
• CAS号: 102067-84-5
• 分子量: 284.263
• 密度: 1.5±0.1 g/cm3
• 沸点: 605.5±55.0 °C at 760 mmHg
• 分子式: C₁₆H₁₂O₅
• 熔点: N/A
• 闪点: 233.2±25.0 °C

苏木酮A用途

苏丹酮A是一种高异黄酮,通过调节Nrf2和NF-κB发挥抗炎作用。苏丹酮可以减轻卵清蛋白诱导的哮喘中的过敏性气道炎症[1]。

苏木酮A名称

• 中文名: 苏木酮A
• 英文名: Sappanone A

苏木酮A生物活性

• 描述: 苏丹酮A是一种高异黄酮,通过调节Nrf2和NF-κB发挥抗炎作用。苏丹酮可以减轻卵清蛋白诱导的哮喘中的过敏性气道炎症[1]。
• 相关类别:
  信号通路 >> NF-κB信号通路 >> KEAP1-Nrf2
  研究领域 >> 炎症/免疫
• 参考文献:

  [1]. Lee S, et, al. Sappanone A exhibits anti-inflammatory effects via modulation of Nrf2 and NF-κB. Int Immunopharmacol. 2015 Sep;28(1):328-36.

  [2]. Liu X, et, al. Sappanone A Attenuates Allergic Airway Inflammation in Ovalbumin-Induced Asthma. Int Arch Allergy Immunol. 2016;170(3):180-6.

苏木酮A物理化学性质

• 密度: 1.5±0.1 g/cm3
• 沸点: 605.5±55.0 °C at 760 mmHg
• 分子式: C₁₆H₁₂O₅
• 分子量: 284.263
• 闪点: 233.2±25.0 °C
• 精确质量: 284.068481
• LogP: 2.49
• InChIKey: KVYZXXBTJHJISR-YHYXMXQVSA-N
• SMILES: O=C1C(=Cc2ccc(O)c(O)c2)COc2cc(O)ccc21
• 蒸汽压: 0.0±1.8 mmHg at 25°C
• 折射率: 1.754
• 储存条件: -20°C，密闭，干燥

苏木酮A靶点实验

查看更多实验

实验名称：Antioxidant activity assessed as nitric oxide free radical scavenging activity by UV-... 来源：ChEMBL 靶标：N/A External Id：CHEMBL2209569

实验名称：Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induc... 来源：ChEMBL 靶标：RAW264.7 External Id：CHEMBL2209570

实验名称：Cytotoxicity against mouse RAW264.7 cells at 50 uM incubated for 24 hrs in presence o... 来源：ChEMBL 靶标：RAW264.7 External Id：CHEMBL2209567

实验名称：Cytotoxicity against mouse RAW264.7 cells at 50 uM incubated for 24 hrs in absence of... 来源：ChEMBL 靶标：RAW264.7 External Id：CHEMBL2209568

实验名称：Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induc... 来源：ChEMBL 靶标：RAW264.7 External Id：CHEMBL2209571

实验名称：Inhibition of KDR at 10 uM by ELISA 来源：ChEMBL 靶标：Vascular endothelial growth factor receptor 2 External Id：CHEMBL986515

实验名称：Antiinflammatory activity in mouse RAW264.7 cells assessed as reduction of LPS-induce... 来源：ChEMBL 靶标：RAW264.7 External Id：CHEMBL2209561

实验名称：Antiinflammatory activity in mouse RAW264.7 cells assessed as reduction of LPS-induce... 来源：ChEMBL 靶标：RAW264.7 External Id：CHEMBL2209562

实验名称：Inhibition of EGFR at 10 uM by ELISA 来源：ChEMBL 靶标：Epidermal growth factor receptor External Id：CHEMBL986517

实验名称：Inhibition of c-Src at 10 uM by ELISA 来源：ChEMBL 靶标：Proto-oncogene tyrosine-protein kinase Src External Id：CHEMBL986511

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苏木酮A英文别名

• 3-(3,4-Dihydroxybenzylidene)-7-hydroxy-2,3-dihydro-4H-chromen-4-one