CEP-28122

• 常用名: CEP-28122
• 英文名: CEP-28122
• CAS号: 1022958-60-6
• 分子量: 539.069
• 密度: 1.4±0.1 g/cm3
• 沸点: 786.9±70.0 °C at 760 mmHg
• 分子式: C₂₈H₃₅ClN₆O₃
• 熔点: N/A
• 闪点: 429.7±35.7 °C

CEP-28122用途

CEP-28122是一种高度有效的选择性ALK抑制剂, IC50值为1.9 ± 0.5 nM。

CEP-28122名称

• 中文名: CEP-28122
• 英文名: cep-28122

CEP-28122生物活性

• 描述: CEP-28122是一种高度有效的选择性ALK抑制剂, IC50值为1.9 ± 0.5 nM。
• 相关类别:
  信号通路 >> 蛋白酪氨酸激酶 >> ALK
  研究领域 >> 癌症
• 参考文献:

  [1]. Cheng M, et al. CEP-28122, a highly potent and selective orally active inhibitor of anaplastic lymphoma kinase with antitumor activity in experimental models of human cancers. Mol Cancer Ther. 2012 Mar;11(3):670-679.

CEP-28122物理化学性质

• 密度: 1.4±0.1 g/cm3
• 沸点: 786.9±70.0 °C at 760 mmHg
• 分子式: C₂₈H₃₅ClN₆O₃
• 分子量: 539.069
• 闪点: 429.7±35.7 °C
• 精确质量: 538.245911
• PSA: 114.63000
• LogP: 1.47
• InChIKey: LAJAFFLJAJMYLK-KXINBKKUSA-N
• SMILES: COc1c(Nc2ncc(Cl)c(NC3C4C=CC(C4)C3C(N)=O)n2)ccc2c1CCC(N1CCOCC1)CC2
• 蒸汽压: 0.0±2.7 mmHg at 25°C
• 折射率: 1.665
• 储存条件: 2-8℃

CEP-28122靶点实验

查看更多实验

实验名称：Diffuse intrinsic pontine glioma (SU-DIPG-XVII) cell line screen of MIPE5.0 library: ... 来源：15316 靶标：N/A External Id：s-dipg-DIPG17_CTG48h_mipe5_0-1

实验名称：Diffuse intrinsic pontine glioma (SU-DIPG-XXV) cell line screen of MIPE5.0 library: v... 来源：15316 靶标：N/A External Id：s-dipg-DIPG25-MIPE5.0-CTF48h-p1

实验名称：Cellular viability qHTS for adrenocortical cancer (ACC) cell line SW-13 来源：NCGC 靶标：N/A External Id：ACC-ATC-p1-SW13-72hr

实验名称：Cellular viability qHTS for adrenocortical cancer (ACC) cell line NCI-H295R 来源：NCGC 靶标：N/A External Id：ACC-ATC-p1-H295R-72hr

实验名称：Primary qHTS for inhibitors of nuclear receptor binding SET domain protein 2 (NSD2) i... 来源：NCGC External Id：NSD2-synergy-p-2C

实验名称：Cytotoxicity counterscreen for inhibitors of SARS-CoV-2 cell entry 来源：NCGC 靶标：N/A External Id：TRND-SARS-CoV-2-cytotox-48hr

实验名称：Diffuse intrinsic pontine glioma (SU-DIPG-XIII) cell line screen of MIPE5.0 library: ... 来源：15316 靶标：N/A External Id：s-dipg-DIPG13_CTG48h_mipe5_0-1

实验名称：Primary qHTS for inhibitors of nuclear receptor binding SET domain protein 2 (NSD2) i... 来源：NCGC External Id：NSD2-synergy-p-9B

实验名称：Diffuse intrinsic pontine glioma (SU-DIPG-XXV) cell line screen of MIPE5.0 library: v... 来源：15316 靶标：N/A External Id：s-dipg-DIPG25_CTG48h_mipe5_0-2

实验名称：Viability qHTS for spleen associated tyrosine kinase inhibitor (SYKi) drug resistant ... 来源：NCGC External Id：s-sky_synergy-MV-411_DR-CTG72-MIPE_NPC_NPACT_Kinase-p1

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CEP-28122英文别名

• (1S,2S,3R,4R)-3-[(5-Chloro-2-{[(7S)-1-methoxy-7-(4-morpholinyl)-6,7,8,9-tetrahydro-5H-benzo[7]annulen-2-yl]amino}-4-pyrimidinyl)amino]bicyclo[2.2.1]hept-5-ene-2-carboxamide
• CEP 28122