GAT-211

• 常用名: GAT-211
• 英文名: GAT-211
• CAS号: 102704-40-5
• 分子量: 342.391
• 密度: 1.2±0.1 g/cm3
• 沸点: 585.8±50.0 °C at 760 mmHg
• 分子式: C₂₂H₁₈N₂O₂
• 熔点: N/A
• 闪点: 308.1±30.1 °C

GAT-211用途

GAT-211(GAT211)是一种选择性大麻素1受体(CB1R)阳性变构调节剂,pKb为7.26,Arrestin2 EC50为775 nM；参与CB1R变构位点,增强正构完全激动剂[3H]CP55490的结合,并减少正构拮抗剂/反向激动剂[3H]SR141716A的结合；在表达人重组CB1R(hCB1R)的HEK293A和Neuro2a细胞以及富含天然CB1R的小鼠脑膜中显示PAM和激动剂活性。

GAT-211名称

• 英文名: GAT211

GAT-211生物活性

• 描述: GAT-211(GAT211)是一种选择性大麻素1受体(CB1R)阳性变构调节剂,pKb为7.26,Arrestin2 EC50为775 nM；参与CB1R变构位点,增强正构完全激动剂[3H]CP55490的结合,并减少正构拮抗剂/反向激动剂[3H]SR141716A的结合；在表达人重组CB1R(hCB1R)的HEK293A和Neuro2a细胞以及富含天然CB1R的小鼠脑膜中显示PAM和激动剂活性。
• 参考文献: References 1. Laprairie RB, et al. ACS Chem Neurosci. 2017 Jun 21;8(6):1188-1203. View Related Products by Target Cannabinoid Receptor

GAT-211物理化学性质

• 密度: 1.2±0.1 g/cm3
• 沸点: 585.8±50.0 °C at 760 mmHg
• 分子式: C₂₂H₁₈N₂O₂
• 分子量: 342.391
• 闪点: 308.1±30.1 °C
• 精确质量: 342.136841
• LogP: 6.23
• InChIKey: OHZDCJJHWPHZJD-UHFFFAOYSA-N
• SMILES: O=[N+]([O-])CC(c1ccccc1)c1c(-c2ccccc2)[nH]c2ccccc12
• 蒸汽压: 0.0±1.6 mmHg at 25°C
• 折射率: 1.668

GAT-211靶点实验

查看更多实验

实验名称：Positive allosteric modulatory activity at N-terminal GFP-tagged rat CB1R receptor ex... 来源：ChEMBL 靶标：Cannabinoid receptor 1 External Id：CHEMBL4379819

实验名称：Positive allosteric modulatory activity at N-terminal GFP-tagged rat CB1R receptor ex... 来源：ChEMBL 靶标：Cannabinoid receptor 1 External Id：CHEMBL4379820

实验名称：Positive allosteric modulatory activity at human CB1R expressed in CHO-K1 cells asses... 来源：ChEMBL 靶标：Cannabinoid receptor 1 External Id：CHEMBL4379797

实验名称：Positive allosteric modulatory activity at human CB1R expressed in CHO-K1 cells asses... 来源：ChEMBL 靶标：Cannabinoid receptor 1 External Id：CHEMBL4379798

实验名称：Positive allosteric modulatory activity at human CB1 receptor expressed in CHO-K1 cel... 来源：ChEMBL 靶标：Cannabinoid receptor 1 External Id：CHEMBL4672175

实验名称：Kinetic solubility of compound in PBS at pH 7.4 incubated for 2 hrs by turbidimetric ... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4672174

实验名称：Positive allosteric modulatory activity at mouse CB1R expressed in CHO-K1 cells asses... 来源：ChEMBL 靶标：Cannabinoid receptor 1 External Id：CHEMBL4368289

实验名称：Positive allosteric modulatory activity at mouse CB1R expressed in CHO-K1 cells asses... 来源：ChEMBL 靶标：Cannabinoid receptor 1 External Id：CHEMBL4368288

实验名称：Positive allosteric modulatory activity at human CB1R expressed in CHO-K1 cells asses... 来源：ChEMBL 靶标：Cannabinoid receptor 1 External Id：CHEMBL4368287

实验名称：Positive allosteric modulatory activity at human CB1R expressed in CHO-K1 cells asses... 来源：ChEMBL 靶标：Cannabinoid receptor 1 External Id：CHEMBL4368286

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GAT-211英文别名

• MFCD02165420
• GAT211
• 3-(2-Nitro-1-phenylethyl)-2-phenyl-1H-indole