GAT-211
Modify Date: 2023-01-18 22:05:37
GAT-211 structure
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Common Name | GAT-211 | ||
|---|---|---|---|---|
| CAS Number | 102704-40-5 | Molecular Weight | 342.391 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 585.8±50.0 °C at 760 mmHg | |
| Molecular Formula | C22H18N2O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 308.1±30.1 °C | |
Use of GAT-211GAT-211 (GAT211) is a selective cannabinoid 1 receptor (CB1R) positive allosteric modulator with pKb of 7.26, Arrestin2 EC50 of 775 nM; engages CB1R allosteric site(s), enhances the binding of the orthosteric full agonist [3H]CP55,490, and reduces the binding of the orthosteric antagonist/inverse agonist [3H]SR141716A; displayed both PAM and agonist activity in HEK293A and Neuro2a cells expressing human recombinant CB1R (hCB1R) and in mouse-brain membranes rich in native CB1R. |
| Name | GAT211 |
|---|---|
| Synonym | More Synonyms |
| Description | GAT-211 (GAT211) is a selective cannabinoid 1 receptor (CB1R) positive allosteric modulator with pKb of 7.26, Arrestin2 EC50 of 775 nM; engages CB1R allosteric site(s), enhances the binding of the orthosteric full agonist [3H]CP55,490, and reduces the binding of the orthosteric antagonist/inverse agonist [3H]SR141716A; displayed both PAM and agonist activity in HEK293A and Neuro2a cells expressing human recombinant CB1R (hCB1R) and in mouse-brain membranes rich in native CB1R. |
|---|---|
| References | References 1. Laprairie RB, et al. ACS Chem Neurosci. 2017 Jun 21;8(6):1188-1203. View Related Products by Target Cannabinoid Receptor |
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 585.8±50.0 °C at 760 mmHg |
| Molecular Formula | C22H18N2O2 |
| Molecular Weight | 342.391 |
| Flash Point | 308.1±30.1 °C |
| Exact Mass | 342.136841 |
| LogP | 6.23 |
| Vapour Pressure | 0.0±1.6 mmHg at 25°C |
| Index of Refraction | 1.668 |
| MFCD02165420 |
| 1H-Indole, 3-(2-nitro-1-phenylethyl)-2-phenyl- |
| GAT211 |
| 3-(2-Nitro-1-phenylethyl)-2-phenyl-1H-indole |