Nanterinone

• 常用名: Nanterinone
• 英文名: Nanterinone
• CAS号: 102791-47-9
• 分子量: 253.29900
• 密度: 1.24g/cm3
• 沸点: N/A
• 分子式: C₁₅H₁₅N₃O
• 熔点: N/A
• 闪点: N/A

Nanterinone用途

Nanterinone (UK 61260) 是一种正性肌力和动脉血管舒张剂。Nanterinone 是一种磷酸二酯酶抑制剂。

Nanterinone名称

• 英文名: 6-(2,4-dimethylimidazol-1-yl)-8-methyl-1H-quinolin-2-one

Nanterinone生物活性

• 描述: Nanterinone (UK 61260) 是一种正性肌力和动脉血管舒张剂。Nanterinone 是一种磷酸二酯酶抑制剂。
• 相关类别:
  研究领域 >> 心血管疾病
  信号通路 >> 代谢酶/蛋白酶 >> 磷酸二酯酶(PDE)
• 参考文献:

  [1]. Remme WJ, et al. Acute hemodynamic effects and preload-dependent cardiovascular profile of the partial phosphodiesterase inhibitor nanterinone in patients with mild to moderate heart failure. Cardiovasc Drugs Ther. 1996 May;10(2):137-44.

Nanterinone物理化学性质

• 密度: 1.24g/cm3
• 分子式: C₁₅H₁₅N₃O
• 分子量: 253.29900
• 精确质量: 253.12200
• PSA: 50.94000
• LogP: 3.05130
• InChIKey: NMNXBEXPAHSXOK-UHFFFAOYSA-N
• SMILES: Cc1cn(-c2cc(C)c3[nH]c(=O)ccc3c2)c(C)n1
• 折射率: 1.651

Nanterinone靶点实验

查看更多实验

实验名称：Compound was examined for effects on cardiac contractility to decrease in QA interval... 来源：ChEMBL 靶标：Canis lupus familiaris External Id：CHEMBL671679

实验名称：0.25 mg/kg of compound was administered orally to conscious adult Beagle dogs and the... 来源：ChEMBL 靶标：Canis lupus familiaris External Id：CHEMBL665509

实验名称：0.25 mg/kg of compound was administered orally to conscious adult Beagle dogs and the... 来源：ChEMBL 靶标：Canis lupus familiaris External Id：CHEMBL671285

实验名称：Compound was tested for cardiotonic activity after intravenous administration of 12.5... 来源：ChEMBL 靶标：Canis lupus familiaris External Id：CHEMBL672052

实验名称：Relative inotropic potency compared with 4-[4-[2-(1,1-dioxo-2-isothiazolidinyl)ethyl]... 来源：ChEMBL 靶标：Canis lupus familiaris External Id：CHEMBL667589

实验名称：Positive inotropic activity after intravenous administration of 12.5 ug/kg (dose) to ... 来源：ChEMBL 靶标：Canis lupus familiaris External Id：CHEMBL667304

实验名称：Compound was examined for effects on cardiac contractility after oral administration ... 来源：ChEMBL 靶标：Canis lupus familiaris External Id：CHEMBL671674

实验名称：Inotropic potencies relative to 4-[4-[2-(1,1-dioxo-2-isothiazolidinyl)ethyl]-1-piperi... 来源：ChEMBL 靶标：Canis lupus familiaris External Id：CHEMBL667581

实验名称：Dissociation constant was determined 来源：ChEMBL 靶标：N/A External Id：CHEMBL633256

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Nanterinone英文别名

• 6-(2,4-dimethylimidazol-1-yl)-8-methyl-2(1H)-quinolinone
• 6-(2,4-dimethyl-1h-imidazol-1-yl)-8-methylquinolin-2-ol
• 8-Methyl-6-(2,4-dimethylimidazol-1-yl)-2(1H)-quinazolinone
• 2(1H)-Quinolinone,6-(2,4-dimethyl-1H-imidazol-1-yl)-8-methyl
• Nanterinone
• UK-61,260
• 6-(2,4-dimethylimidazol-1-yl)-8-methyl-2-(1H)-quinolone