BC-7013

• 常用名: BC-7013
• 英文名: BC-7013
• CAS号: 1028291-66-8
• 分子量: 500.69
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₉H₄₀O₅S
• 熔点: N/A
• 闪点: N/A

BC-7013用途

BC-7013是一种新型的半合成胸膜菌素衍生物。BC-7013对革兰氏阳性致病菌具有良好的抗菌活性。BC-7013对葡萄球菌、链球菌和耐青霉素肺炎链球菌均表现出强大的抗菌性能。BC-7013具有抗革兰氏阳性致病菌的活性,可用于急性细菌性皮肤和皮肤结构感染(ABSSSI)的研究[1]。

BC-7013名称

• 英文名: BC-7013

BC-7013生物活性

• 描述: BC-7013是一种新型的半合成胸膜菌素衍生物。BC-7013对革兰氏阳性致病菌具有良好的抗菌活性。BC-7013对葡萄球菌、链球菌和耐青霉素肺炎链球菌均表现出强大的抗菌性能。BC-7013具有抗革兰氏阳性致病菌的活性,可用于急性细菌性皮肤和皮肤结构感染(ABSSSI)的研究[1]。
• 相关类别:
  研究领域 >> 感染
  信号通路 >> 抗感染 >> 细菌
• 靶点实验:

  MIC50: 0.015µg/mL (303 tested S. aureus isolates)[2]

• 体外研究: BC-7013对 303株金黄色葡萄球菌有很强的抑制活性,MIC50值为 0.015µg/mL[2]BC-7013对 A.组链球菌和 B组链球菌表现出强大的活性,MIC90值分别为 0.03µg/mL和 0.06µg/mL[2]
• 参考文献:

  [1]. Shang R, et al. Efficient antibacterial agents: a review of the synthesis, biological evaluation and mechanism of pleuromutilin derivatives. Curr Top Med Chem. 2013;13(24):3013-25.

  [2]. Biedenbach D J, et al. In vitro antibacterial spectrum of BC-7013, a novel pleuromutilin derivative for topical use in humans. Interscience Conference on Antimicrobial Agents and Chemotherapy. 2009, 49: 199

BC-7013物理化学性质

• 分子式: C₂₉H₄₀O₅S
• 分子量: 500.69
• InChIKey: KELRBTWVTDHIHS-KGTFJIFRSA-N
• SMILES: C=CC1(C)CC(OC(=O)CSc2cccc(CO)c2)C2(C)C(C)CCC3(CCC(=O)C32)C(C)C1O

BC-7013靶点实验

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实验名称：Inhibition of CYP2C9 in human liver microsomes using tolbutamide as substrate after 1... 来源：ChEMBL 靶标：Cytochrome P450 2C9 External Id：CHEMBL3297535

实验名称：Inhibition of CYP1A2 in human liver microsomes using phenacetin as substrate after 15... 来源：ChEMBL 靶标：Cytochrome P450 1A2 External Id：CHEMBL3297534

实验名称：Inhibition of CYP2D6 in human liver microsomes using dextromethorphan as substrate af... 来源：ChEMBL 靶标：Cytochrome P450 2D6 External Id：CHEMBL3297537

实验名称：Antibacterial activity against Staphylococcus aureus ATCC 292135 after 16 hrs by agar... 来源：ChEMBL 靶标：Staphylococcus aureus External Id：CHEMBL3296588

实验名称：Inhibition of CYP2C19 in human liver microsomes using mephenytoin as substrate after ... 来源：ChEMBL 靶标：Cytochrome P450 2C19 External Id：CHEMBL3297536

实验名称：Inhibition of CYP3A4 in human liver microsomes using testosterone as substrate after ... 来源：ChEMBL 靶标：Cytochrome P450 3A4 External Id：CHEMBL3297539

实验名称：Antibacterial activity against methicillin-resistant Staphylococcus aureus after 16 h... 来源：ChEMBL 靶标：Staphylococcus aureus External Id：CHEMBL3296590

实验名称：Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate after 15 ... 来源：ChEMBL 靶标：Cytochrome P450 3A4 External Id：CHEMBL3297538

实验名称：Antibacterial activity against methicillin-sensitive Staphylococcus aureus after 16 h... 来源：ChEMBL 靶标：Staphylococcus aureus External Id：CHEMBL3296589

实验名称：Antibacterial activity against penicillin-resistant Streptococcus pneumoniae after 16... 来源：ChEMBL 靶标：Streptococcus pneumoniae External Id：CHEMBL3296592

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