AS2034178 free base

• 常用名: AS2034178 free base
• 英文名: AS 2034178
• CAS号: 1030846-42-4
• 分子量: 448.52900
• 密度: 1.2±0.1 g/cm3
• 沸点: 657.9±55.0 °C at 760 mmHg
• 分子式: C₂₇H₂₉FN₂O₃
• 熔点: N/A
• 闪点: 351.7±31.5 °C

AS2034178 free base用途

AS2034178 free base,一种特异的、具有口服活性的 GPR40 的激动剂,表现葡萄糖依赖性胰岛素分泌增强。AS2034178 free base 在 2 型糖尿病研究中具有潜在的应用前景。

AS2034178 free base名称

• 英文名: 3-[2-Fluoro-4-({[1-(2-phenoxyethyl)-1,2,3,4-tetrahydro-5-quinolinyl]methyl}amino)phenyl]propanoic acid

AS2034178 free base生物活性

• 描述: AS2034178 free base,一种特异的、具有口服活性的 GPR40 的激动剂,表现葡萄糖依赖性胰岛素分泌增强。AS2034178 free base 在 2 型糖尿病研究中具有潜在的应用前景。
• 相关类别:
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> GPR40
  研究领域 >> 代谢疾病
• 参考文献:

  [1]. Tanaka H, et al. Chronic treatment with novel GPR40 agonists improve whole-body glucose metabolism based on the glucose-dependent insulin secretion. J Pharmacol Exp Ther. 2013;346(3):443-452.

AS2034178 free base物理化学性质

• 密度: 1.2±0.1 g/cm3
• 沸点: 657.9±55.0 °C at 760 mmHg
• 分子式: C₂₇H₂₉FN₂O₃
• 分子量: 448.52900
• 闪点: 351.7±31.5 °C
• 精确质量: 448.21600
• PSA: 61.80000
• LogP: 5.44
• InChIKey: VENOXIKBBUVHRY-UHFFFAOYSA-N
• SMILES: O=C(O)CCc1ccc(NCc2cccc3c2CCCN3CCOc2ccccc2)cc1F
• 蒸汽压: 0.0±2.1 mmHg at 25°C
• 折射率: 1.622

AS2034178 free base靶点实验

查看更多实验

实验名称：Primary qHTS assay for small molecule inhibitors of Inositol hexaphosphate kinase 1 (... 来源：NCGC External Id：IP6K1-p1

实验名称：Cytochrome P450 family 3 subfamily A member 4 (CYP3A4) small molecule antagonists: lu... 来源：NCGC External Id：CYP3A4437

实验名称：Cytochrome P450 family 2 subfamily D member 6 (CYP2D6) small molecule antagonists: lu... 来源：NCGC External Id：CYP2D6395

实验名称：Cytochrome P450 family 2 subfamily C member 9 (CYP2C9) small molecule antagonists: lu... 来源：NCGC External Id：CYP2C9536

实验名称：SARS-CoV-2 3CL-Pro protease inhibition percentage at 20µM by FRET kind of response f... 来源：ChEMBL 靶标：Replicase polyprotein 1ab External Id：CHEMBL4495582

实验名称：Cytochrome P450 family 3 subfamily A member 7 (CYP3A7) small molecule antagonists: lu... 来源：NCGC External Id：CYP3A7681

实验名称：Enzymatic assay of human HDAC6 with commercial peptide substrate 来源：ChEMBL 靶标：Histone deacetylase 6 External Id：CHEMBL4808149

实验名称：Enzymatic assay of human HDAC6 with custom peptide substrate 来源：ChEMBL 靶标：Histone deacetylase 6 External Id：CHEMBL4808150

实验名称：Primary qHTS for inhibitors of NSP2Pro chikungunya virus (CHIKV) 来源：NCGC External Id：APP-Toga-CHIKV-nsp2-p

实验名称：qHTS assay to identify novel small-molecules to repurpose for Merkel cell carcinoma t... 来源：NCGC 靶标：N/A External Id：MCC011

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AS2034178 free base英文别名

• 3-[2-Fluoro-4-({[1-(2-phenoxyethyl)-1,2,3,4-tetrahydro-5-quinolinyl]methyl}amino)phenyl]propanoic acid
• AS2034178