MC-70

• 常用名: MC-70
• 英文名: MC-70
• CAS号: 1031367-64-2
• 分子量: 375.46
• 密度: 1.2±0.1 g/cm3
• 沸点: 536.6±50.0 °C at 760 mmHg
• 分子式: C₂₄H₂₅NO₃
• 熔点: N/A
• 闪点: 278.3±30.1 °C

MC-70用途

MC70是一种有效的非选择性P糖蛋白(P-gp)抑制剂,EC50为0.69µM。MC70是一种ABC转运蛋白抑制剂和抗癌剂。MC70与ABCB1、ABCG2和ABCC1相互作用[1][2]。

MC-70名称

• 英文名: MC70

MC-70生物活性

• 描述: MC70是一种有效的非选择性P糖蛋白(P-gp)抑制剂,EC50为0.69µM。MC70是一种ABC转运蛋白抑制剂和抗癌剂。MC70与ABCB1、ABCG2和ABCC1相互作用[1][2]。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 跨膜转运 >> P-糖蛋白
• 靶点实验:

  EC50: 0.69 µM (P-glycoprotein)[1]

• 参考文献:

  [1]. Stefano Guglielmo, et al. Structure-Activity Relationship Studies on Tetrahydroisoquinoline Derivatives: [4'-(6,7-Dimethoxy-3,4-dihydro-1H-isoquinolin-2-ylmethyl)biphenyl-4-ol] (MC70) Conjugated through Flexible Alkyl Chains with Furazan Moieties Gives Rise to Potent and Selective Ligands of P-glycoprotein. J Med Chem. 2016 Jul 28;59(14):6729-38.

  [2]. Amalia Azzariti, et al. MC70 potentiates doxorubicin efficacy in colon and breast cancer in vitro treatment. Eur J Pharmacol. 2011 Nov 16;670(1):74-84.

MC-70物理化学性质

• 密度: 1.2±0.1 g/cm3
• 沸点: 536.6±50.0 °C at 760 mmHg
• 分子式: C₂₄H₂₅NO₃
• 分子量: 375.46
• 闪点: 278.3±30.1 °C
• 精确质量: 375.183441
• LogP: 4.22
• InChIKey: ATYXTVKHMLAWBZ-UHFFFAOYSA-N
• SMILES: COc1cc2c(cc1OC)CN(Cc1ccc(-c3ccc(O)cc3)cc1)CC2
• 蒸汽压: 0.0±1.5 mmHg at 25°C
• 折射率: 1.617

MC-70靶点实验

查看更多实验

实验名称：Inhibition of MDR1 (unknown origin) expressed in MDCK cells assessed as increase in d... 来源：ChEMBL 靶标：ATP-dependent translocase ABCB1 External Id：CHEMBL4259150

实验名称：Activation of human P-gp ATPase in human Caco-2 cells at 100 uM 来源：ChEMBL 靶标：ATP-dependent translocase ABCB1 External Id：CHEMBL923493

实验名称：Downregulation of MDR1 protein expression in MDCK-MDR1 cells at 10 uM after 48 hrs by... 来源：ChEMBL 靶标：MDCK External Id：CHEMBL4259151

实验名称：Inhibition of human P-gp mediated [3H]vinblastine transport activity in human Caco-2 ... 来源：ChEMBL 靶标：N/A External Id：CHEMBL923490

实验名称：Efflux ratio of permeability in dog MDCK-MDR1 cells 来源：ChEMBL 靶标：N/A External Id：CHEMBL5236869

实验名称：Efflux ratio of apparent permeability from basolateral to apical over apical to basol... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4259148

实验名称：Activity at MRP1 (unknown origin) expressed in MDCK cells assessed as interference ca... 来源：ChEMBL 靶标：Multidrug resistance-associated protein 1 External Id：CHEMBL2341934

实验名称：Inhibition of MDR1 (unknown origin) expressed in MDCK cells assessed as reduction in ... 来源：ChEMBL 靶标：ATP-dependent translocase ABCB1 External Id：CHEMBL4259147

实验名称：Activity at MDR1 (unknown origin) expressed in MDCK cells assessed as interference wi... 来源：ChEMBL 靶标：ATP-dependent translocase ABCB1 External Id：CHEMBL2341933

实验名称：Inhibition of human BCRP mediated [3H]mitoxantrone transport activity in human Caco-2... 来源：ChEMBL 靶标：Broad substrate specificity ATP-binding cassette transporter ABCG2 External Id：CHEMBL923498

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MC-70英文别名

• 4'-[(6,7-Dimethoxy-3,4-dihydro-2(1H)-isoquinolinyl)methyl]-4-biphenylol
• 4'-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-ylmethyl)biphenyl-4-ol; MC70
• 4'-[(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)methyl]biphenyl-4-ol