gsk 1292263

• 常用名: gsk 1292263
• 英文名: GSK1292263
• CAS号: 1032823-75-8
• 分子量: 456.558
• 密度: 1.2±0.1 g/cm3
• 沸点: 655.1±65.0 °C at 760 mmHg
• 分子式: C₂₃H₂₈N₄O₄S
• 熔点: N/A
• 闪点: 350.0±34.3 °C

gsk 1292263用途

GSK1292263是PR119受体激动剂,可用于2型糖尿病。

gsk 1292263名称

• 中文名: 5-[[[1-(3-异丙基-1,2,4-噁二唑-5-基)-4-哌啶基]甲基]氧基]-2-[4-(甲磺酰基)苯基]吡啶
• 英文名: 5-[4-[[6-(4-methylsulfonylphenyl)pyridin-3-yl]oxymethyl]piperidin-1-yl]-3-propan-2-yl-1,2,4-oxadiazole

gsk 1292263生物活性

• 描述: GSK1292263是PR119受体激动剂,可用于2型糖尿病。
• 相关类别:
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> GPR119
  研究领域 >> 炎症/免疫
  研究领域 >> 代谢疾病
• 参考文献:

  [1]. Zhu X, et al. The first pharmacophore model for potent G protein-coupled receptor 119 agonist. Eur J Med Chem, 2011, 46(7), 2901-2907.

  [2]. Brown KK, et al. Diabetes, 2010, 59(Suppl. 1), Abst 1733-P.

  [3]. Yang JW, et al. GPR119: a promising target for nonalcoholic fatty liver disease. FASEB J. 2016 Jan;30(1):324-35.

gsk 1292263物理化学性质

• 密度: 1.2±0.1 g/cm3
• 沸点: 655.1±65.0 °C at 760 mmHg
• 分子式: C₂₃H₂₈N₄O₄S
• 分子量: 456.558
• 闪点: 350.0±34.3 °C
• 精确质量: 456.183136
• PSA: 106.80000
• LogP: 1.67
• InChIKey: AYJRTVVIBJSSKN-UHFFFAOYSA-N
• SMILES: CC(C)c1noc(N2CCC(COc3ccc(-c4ccc(S(C)(=O)=O)cc4)nc3)CC2)n1
• 外观性状: 粉末
• 蒸汽压: 0.0±2.0 mmHg at 25°C
• 折射率: 1.565
• 储存条件: -20℃

gsk 1292263靶点实验

查看更多实验

实验名称：Thermal Shift Assay. Domain: start/stop: M1-L298 来源：ChEMBL 靶标：Cyclin-dependent kinase 2 External Id：CHEMBL5062802

实验名称：Primary qHTS assay for inhibitors of alpha-synuclein gene (SNCA) expression 来源：NCGC External Id：SNCA-p-activity-luciferase

实验名称：Thermal Shift Assay. Domain: start/stop: N44-E168 来源：ChEMBL 靶标：Bromodomain-containing protein 4 External Id：CHEMBL5061247

实验名称：Quantitative High-Throughput drug screen in 47 multiple myeloma cell lines against th... 来源：NCGC 靶标：N/A External Id：s-my-keats_OPM1-m4-1

实验名称：Quantitative High-Throughput drug screen in 47 multiple myeloma cell lines against th... 来源：NCGC 靶标：N/A External Id：s-my-OC1MY5-m4-1

实验名称：Quantitative High-Throughput drug screen in 47 multiple myeloma cell lines against th... 来源：NCGC 靶标：N/A External Id：s-my-KMS_34-m4-1

实验名称：Incucyte cell viability with HEK293T 来源：ChEMBL 靶标：HEK-293T External Id：CHEMBL5058565

实验名称：Quantitative High-Throughput drug screen in 47 multiple myeloma cell lines against th... 来源：NCGC 靶标：N/A External Id：s-my-keats_L363-m4-1

实验名称：Quantitative High-Throughput drug screen in 47 multiple myeloma cell lines against th... 来源：NCGC 靶标：N/A External Id：s-my-keats_OCIMY7-m4-1

实验名称：Quantitative High-Throughput drug screen in 47 multiple myeloma cell lines against th... 来源：NCGC 靶标：N/A External Id：s-my-MM1R-m4-1

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gsk 1292263英文别名

• 5-{[1-(3-Isopropyl-1,2,4-oxadiazol-5-yl)-4-piperidinyl]methoxy}-2-[4-(methylsulfonyl)phenyl]pyridine
• GSK1292263
• 3-Isopropyl-5-(4-(((6-(4-(methylsulfonyl)phenyl)pyridin-3-yl)oxy)methyl)piperidin-1-yl)-1,2,4-oxadiazole