GSK-1520489A

• 常用名: GSK-1520489A
• 英文名: GSK-1520489A
• CAS号: 1042433-41-9
• 分子量: 425.50
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₁H₂₃N₅O₃S
• 熔点: N/A
• 闪点: N/A

GSK-1520489A用途

GSK-1520489A是PKMYT1(活性蛋白激酶)抑制剂(IC50=115 nM,Ki=10.94 nM)[1]。

GSK-1520489A名称

• 英文名: GSK-1520489A

GSK-1520489A生物活性

• 描述: GSK-1520489A是PKMYT1(活性蛋白激酶)抑制剂(IC50=115 nM,Ki=10.94 nM)[1]。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 其他 >> 其他
• 靶点实验:

  IC50: 115 nM (PKMYT1)[1]

• 体外研究: GSK-1520489A(4µM,24小时)处理显示抑制Cdk1中Tyr15的磷酸化[1]。Western印迹分析[1]细胞系：HT29细胞浓度：4µM孵育时间：24小时结果：与未抑制反应相比,酪氨酸处的Cdk1磷酸化减少。
• 参考文献:

  [1]. Charlott Platzer, et al. Identification of PKMYT1 inhibitors by screening the GSK published protein kinase inhibitor set I and II. Bioorg Med Chem. 2018 Aug 7;26(14):4014-4024.

GSK-1520489A物理化学性质

• 分子式: C₂₁H₂₃N₅O₃S
• 分子量: 425.50
• InChIKey: AKHLCKMEVWGDGL-UHFFFAOYSA-N
• SMILES: CNC(=O)c1ccccc1Nc1nc(Nc2cccc(CS(C)(=O)=O)c2)ncc1C

GSK-1520489A靶点实验

查看更多实验

实验名称：Antischistosomal activity against adult Schistosoma mansoni assessed as reduction in ... 来源：ChEMBL 靶标：Schistosoma mansoni External Id：CHEMBL5131330

实验名称：Antischistosomal activity against adult Schistosoma mansoni assessed as reduction in ... 来源：ChEMBL 靶标：Schistosoma mansoni External Id：CHEMBL5131331

实验名称：D3R2021 from Article : "Drug Design Data Resource Grand Challenge 3 Dataset: VEGFR2" 来源：BindingDB 靶标：N/A External Id：BindingDB_11026_1

实验名称：Displacement of (6-FAM)KI(pY)VV from full length PKMYT1 (unknown origin) by fluoresce... 来源：ChEMBL 靶标：Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase External Id：CHEMBL4328727

实验名称：Displacement of (6-FAM)KI(pY)VV from PKMYT1 kinase domain (unknown origin) by fluores... 来源：ChEMBL 靶标：Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase External Id：CHEMBL4328725

实验名称：Inhibition of PKMYT1 in human HT29 cells assessed as decrease in Cdk1 phosphorylation... 来源：ChEMBL 靶标：Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase External Id：CHEMBL4233139

实验名称：GSK PKIS2: Screen against O. lienalis microfilariae, single point, at 3.1uM to assess... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3988182

实验名称：Inhibition of human full length PKMYT1 expressed in HEK293 cells assessed as decrease... 来源：ChEMBL 靶标：Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase External Id：CHEMBL4233138

实验名称：D3R2023 from Article : "Drug Design Data Resource Grand Challenge 3 Dataset: p38a" 来源：BindingDB 靶标：N/A External Id：BindingDB_11028_1

实验名称：D3R2022 from Article : "Drug Design Data Resource Grand Challenge 3 Dataset: JAK2_SC2... 来源：BindingDB 靶标：N/A External Id：BindingDB_11027_1

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