Dagrocorat

• 常用名: Dagrocorat
• 英文名: Dagrocorat
• CAS号: 1044535-52-5
• 分子量: 494.54800
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₉H₂₉F₃N₂O₂
• 熔点: N/A
• 闪点: N/A

Dagrocorat用途

Dagrocorat (PF-00251802) 是一种新型游离态的 glucocorticoid receptor 激动剂。

Dagrocorat名称

• 中文名: Dagrocorat
• 英文名: (4bS,7R,8aR)-4b-benzyl-7-hydroxy-N-(2-methylpyridin-3-yl)-7-(trifluoromethyl)-5,6,8,8a,9,10-hexahydrophenanthrene-2-carboxamide

Dagrocorat生物活性

• 描述: Dagrocorat (PF-00251802) 是一种新型游离态的 glucocorticoid receptor 激动剂。
• 相关类别:
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 糖皮质激素受体
  研究领域 >> 炎症/免疫
• 参考文献:

  [1]. Ripp SL,et al. In Vitro and In Vivo Investigation of Potential for Complex CYP3A Interaction for PF-00251802 (Dagrocorat), a Novel Dissociated Agonist of the Glucocorticoid Receptor. Clin Pharmacol Drug Dev. 2018 Mar;7(3):244-255.

Dagrocorat物理化学性质

• 分子式: C₂₉H₂₉F₃N₂O₂
• 分子量: 494.54800
• 精确质量: 494.21800
• PSA: 62.22000
• LogP: 6.23550
• InChIKey: QJJBNCHSWFGXML-KEKPKEOLSA-N
• SMILES: Cc1ncccc1NC(=O)c1ccc2c(c1)CCC1CC(O)(C(F)(F)F)CCC21Cc1ccccc1

Dagrocorat靶点实验

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实验名称：Therapeutic index, ratio of fIC20 for transrepression of GR in cryopreserved human fe... 来源：ChEMBL 靶标：Glucocorticoid receptor External Id：CHEMBL4194581

实验名称：Transrepression of GR in cryopreserved human fetal osteoblasts assessed as inhibition... 来源：ChEMBL 靶标：Glucocorticoid receptor External Id：CHEMBL4194580

实验名称：Activity at GR in cryopreserved human primary hepatocytes assessed as downregulation ... 来源：ChEMBL 靶标：Glucocorticoid receptor External Id：CHEMBL4194614

实验名称：Transrepression of GR in human whole blood assessed as inhibition of LPS-induced TNF-... 来源：ChEMBL 靶标：Glucocorticoid receptor External Id：CHEMBL4194577

实验名称：Inhibition of TNF alpha production in recombinant human IL-1 beta induced A549 cells ... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5611030

实验名称：Inhibition of IL-6 production in recombinant human IL-1 beta induced A549 cells asses... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5611032

实验名称：Fluorescence Polarization Ligand Binding Assay from US Patent US8901310: "Tricyclic c... 来源：BindingDB 靶标：N/A External Id：BindingDB_6585_1

实验名称：Antagonist activity at glucocorticoid receptor (unknown origin) expressed in human Ch... 来源：ChEMBL 靶标：Glucocorticoid receptor External Id：CHEMBL4194565

实验名称：Antagonist activity at glucocorticoid receptor (unknown origin) expressed in human Ch... 来源：ChEMBL 靶标：Glucocorticoid receptor External Id：CHEMBL4194564

实验名称：Transactivation activity at glucocorticoid receptor (unknown origin) expressed in hum... 来源：ChEMBL 靶标：Glucocorticoid receptor External Id：CHEMBL4194566

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Dagrocorat英文别名

• unii-opm23un90u