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7-Methylguanosine 5'-diphosphate sodium

更新时间:2025-08-27 09:58:11

7-Methylguanosine 5'-diphosphate sodium结构式
7-Methylguanosine 5'-diphosphate sodium结构式
品牌特惠专场
常用名 7-Methylguanosine 5'-diphosphate sodium 英文名 7-Methylguanosine 5'-diphosphate sodium
CAS号 104809-16-7 分子量 459.24300
密度 N/A 沸点 N/A
分子式 C11H19N5O11P2 熔点 N/A
MSDS 美版 闪点 N/A

 用途


7-甲基鸟苷5'-二磷酸(7-甲基-GDP)钠是一种cap类似物,可用于合成mRNA cap类似物[1]。

 名称

中文名 7-甲基鸟苷5'-二磷酸钠盐
英文名 7-methyl-7,8-dihydroguanosine-5'-diphosphate
英文别名 更多

 生物活性

描述 7-甲基鸟苷5'-二磷酸(7-甲基-GDP)钠是一种cap类似物,可用于合成mRNA cap类似物[1]。
相关类别
靶点

Human Endogenous Metabolite

体外研究 7-甲基鸟苷5'-二磷酸钠抑制真核生物起始因子与呼肠孤病毒封盖的mRNA的结合以及涉及未封盖mRNA或18 S rRNA的复合物形成[1]。Tbrucei mRNA去盖酶(TbDcp2),从封端RNA中切割7-甲基鸟苷5'-二磷酸钠以生成pRNA,pRNA是TbCe1的底物[2]。
参考文献

[1]. Sonenberg N, et al. Nonspecific effect of m7GMP on protein-RNA interactions. J Biol Chem. 1978;253(19):6630-6632.

[2]. Ignatochkina AV, et al. The messenger RNA decapping and recapping pathway in Trypanosoma. Proc Natl Acad Sci U S A. 2015;112(22):6967-6972.

 物理化学性质

分子式 C11H19N5O11P2
分子量 459.24300
精确质量 459.05600
PSA 260.85000
储存条件 -20 °C,密封,干燥

 安全信息

个人防护装备 Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
危险品运输编码 NONH for all modes of transport

 文献20

更多文献
Elimination of cap structures generated by mRNA decay involves the new scavenger mRNA decapping enzyme Aph1/FHIT together with DcpS.

Nucleic Acids Res. 43(1) , 482-92, (2015)

Eukaryotic 5' mRNA cap structures participate to the post-transcriptional control of gene expression before being released by the two main mRNA decay pathways. In the 3'-5' pathway, the exosome genera...

Loss of the scavenger mRNA decapping enzyme DCPS causes syndromic intellectual disability with neuromuscular defects.

Hum. Mol. Genet. 24(11) , 3163-71, (2015)

mRNA decay is an essential and active process that allows cells to continuously adapt gene expression to internal and environmental cues. There are two mRNA degradation pathways: 3' to 5' and 5' to 3'...

7-methylguanosine diphosphate (m(7)GDP) is not hydrolyzed but strongly bound by decapping scavenger (DcpS) enzymes and potently inhibits their activity.

Biochemistry 51(40) , 8003-13, (2012)

Decapping scavenger (DcpS) enzymes catalyze the cleavage of a residual cap structure following 3' → 5' mRNA decay. Some previous studies suggested that both m(7)GpppG and m(7)GDP were substrates for D...

 英文别名

MFCD00057869
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