7-Methylguanosine 5'-diphosphate sodium
7-Methylguanosine 5'-diphosphate sodium结构式
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常用名 | 7-Methylguanosine 5'-diphosphate sodium | 英文名 | 7-Methylguanosine 5'-diphosphate sodium |
|---|---|---|---|---|
| CAS号 | 104809-16-7 | 分子量 | 459.24300 | |
| 密度 | N/A | 沸点 | N/A | |
| 分子式 | C11H19N5O11P2 | 熔点 | N/A | |
| MSDS | 美版 | 闪点 | N/A |
用途7-甲基鸟苷5'-二磷酸(7-甲基-GDP)钠是一种cap类似物,可用于合成mRNA cap类似物[1]。 |
| 中文名 | 7-甲基鸟苷5'-二磷酸钠盐 |
|---|---|
| 英文名 | 7-methyl-7,8-dihydroguanosine-5'-diphosphate |
| 英文别名 | 更多 |
| 描述 | 7-甲基鸟苷5'-二磷酸(7-甲基-GDP)钠是一种cap类似物,可用于合成mRNA cap类似物[1]。 |
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| 相关类别 | |
| 靶点 |
Human Endogenous Metabolite |
| 体外研究 | 7-甲基鸟苷5'-二磷酸钠抑制真核生物起始因子与呼肠孤病毒封盖的mRNA的结合以及涉及未封盖mRNA或18 S rRNA的复合物形成[1]。Tbrucei mRNA去盖酶(TbDcp2),从封端RNA中切割7-甲基鸟苷5'-二磷酸钠以生成pRNA,pRNA是TbCe1的底物[2]。 |
| 参考文献 |
| 分子式 | C11H19N5O11P2 |
|---|---|
| 分子量 | 459.24300 |
| 精确质量 | 459.05600 |
| PSA | 260.85000 |
| 储存条件 | -20 °C，密封，干燥 |
| 个人防护装备 | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| 危险品运输编码 | NONH for all modes of transport |
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Elimination of cap structures generated by mRNA decay involves the new scavenger mRNA decapping enzyme Aph1/FHIT together with DcpS.
Nucleic Acids Res. 43(1) , 482-92, (2015) Eukaryotic 5' mRNA cap structures participate to the post-transcriptional control of gene expression before being released by the two main mRNA decay pathways. In the 3'-5' pathway, the exosome genera... |
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Loss of the scavenger mRNA decapping enzyme DCPS causes syndromic intellectual disability with neuromuscular defects.
Hum. Mol. Genet. 24(11) , 3163-71, (2015) mRNA decay is an essential and active process that allows cells to continuously adapt gene expression to internal and environmental cues. There are two mRNA degradation pathways: 3' to 5' and 5' to 3'... |
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7-methylguanosine diphosphate (m(7)GDP) is not hydrolyzed but strongly bound by decapping scavenger (DcpS) enzymes and potently inhibits their activity.
Biochemistry 51(40) , 8003-13, (2012) Decapping scavenger (DcpS) enzymes catalyze the cleavage of a residual cap structure following 3' → 5' mRNA decay. Some previous studies suggested that both m(7)GpppG and m(7)GDP were substrates for D... |
| MFCD00057869 |
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- 上海化源生化科技有限公司
- 上海市 上海市 普陀区
- 产品名：7-Methylguanosine5'-diphosphatesodiumsalt
- 纯度：97.0%
- 规格：
- 联系人：化源网
- 联系电话：133 1186 9306
- 上海阿拉丁生化科技股份有限公司
- 上海市 上海市 浦东新区
- 产品名：7-甲基鸟苷5'-二磷酸钠盐
- 产品网址：http://www.aladdin-e.com/zh_cn/M353080.html
- 纯度：98.0%
- 规格：25mg/10mg/1g/1g
- 联系人：阿拉丁
- 联系电话：400-620-6333
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