7-Methylguanosine 5'-diphosphate sodium
7-Methylguanosine 5'-diphosphate sodium structure
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Common Name | 7-Methylguanosine 5'-diphosphate sodium | ||
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| CAS Number | 104809-16-7 | Molecular Weight | 459.24300 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C11H19N5O11P2 | Melting Point | N/A | |
| MSDS | USA | Flash Point | N/A | |
Use of 7-Methylguanosine 5'-diphosphate sodium7-Methylguanosine 5'-diphosphate (7-Methyl-GDP) sodium, a cap analog, can be used in the synthesis of mRNA cap analogues[1]. |
| Name | 7-methyl-7,8-dihydroguanosine-5'-diphosphate |
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| Synonym | More Synonyms |
| Description | 7-Methylguanosine 5'-diphosphate (7-Methyl-GDP) sodium, a cap analog, can be used in the synthesis of mRNA cap analogues[1]. |
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| Related Catalog | |
| Target |
Human Endogenous Metabolite |
| In Vitro | 7-Methylguanosine 5'-diphosphate sodium inhibits binding of eukaryotic initiation factors to reovirus capped mRNA and complex formation involving uncapped mRNA or 18 S rRNA[1]. T. brucei mRNA decapping enzyme (TbDcp2) that cleaves 7-Methylguanosine 5'-diphosphate sodium from capped RNA to generate pRNA, a substrate for TbCe1[2]. |
| References |
| Molecular Formula | C11H19N5O11P2 |
|---|---|
| Molecular Weight | 459.24300 |
| Exact Mass | 459.05600 |
| PSA | 260.85000 |
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
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| RIDADR | NONH for all modes of transport |
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Elimination of cap structures generated by mRNA decay involves the new scavenger mRNA decapping enzyme Aph1/FHIT together with DcpS.
Nucleic Acids Res. 43(1) , 482-92, (2015) Eukaryotic 5' mRNA cap structures participate to the post-transcriptional control of gene expression before being released by the two main mRNA decay pathways. In the 3'-5' pathway, the exosome genera... |
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Loss of the scavenger mRNA decapping enzyme DCPS causes syndromic intellectual disability with neuromuscular defects.
Hum. Mol. Genet. 24(11) , 3163-71, (2015) mRNA decay is an essential and active process that allows cells to continuously adapt gene expression to internal and environmental cues. There are two mRNA degradation pathways: 3' to 5' and 5' to 3'... |
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7-methylguanosine diphosphate (m(7)GDP) is not hydrolyzed but strongly bound by decapping scavenger (DcpS) enzymes and potently inhibits their activity.
Biochemistry 51(40) , 8003-13, (2012) Decapping scavenger (DcpS) enzymes catalyze the cleavage of a residual cap structure following 3' → 5' mRNA decay. Some previous studies suggested that both m(7)GpppG and m(7)GDP were substrates for D... |
| MFCD00057869 |