MDL 11,939

更新时间：2025-08-24 22:25:19

MDL 11,939结构式	常用名	MDL 11,939	英文名	MDL 11,939
	CAS号	107703-78-6	分子量	295.41900
	密度	1.084g/cm3	沸点	434.2ºC at 760mmHg
	分子式	C₂₀H₂₅NO	熔点	N/A
	MSDS	中文版美版	闪点	205.6ºC
	符号	GHS09	信号词	Warning

MDL 11,939用途

葛兰素(MDL11939)是5-HT2A血清素受体的有效和选择性拮抗剂(大鼠5-HT2A、兔5-HT2A和人5-HT2A的Ki分别为2.89、0.54和2.5 nM)[1][2]。

英文名	MDL 11,939,α-Phenyl-1-(2-phenylethyl)-4-piperidinemethanol
英文别名	更多

描述	葛兰素(MDL11939)是5-HT2A血清素受体的有效和选择性拮抗剂(大鼠5-HT2A、兔5-HT2A和人5-HT2A的Ki分别为2.89、0.54和2.5 nM)[1][2]。
相关类别	研究领域 >> 神经疾病信号通路 >> 神经信号通路 >> 5-羟色胺转运蛋白
体内研究	葛兰素(MDL11939)抑制吗啡诱导的雄性小鼠运动活性、行为敏化和戒断症状的增加[1]。
参考文献	[1]. Pehek EA, et al. Evidence for the preferential involvement of 5-HT2A serotonin receptors in stress- and drug-induced dopamine release in the rat medial prefrontal cortex. Neuropsychopharmacology. 2006;31(2):265-277.

密度	1.084g/cm3
沸点	434.2ºC at 760mmHg
分子式	C₂₀H₂₅NO
分子量	295.41900
闪点	205.6ºC
精确质量	295.19400
PSA	23.47000
LogP	3.61260
InChIKey	AXNGJCOYCMDPQG-UHFFFAOYSA-N
SMILES	OC(c1ccccc1)C1CCN(CCc2ccccc2)CC1

符号	GHS09
信号词	Warning
危害声明	H400
警示性声明	P273
危险品运输编码	UN 3077 9 / PGIII

Selective remodeling of rabbit frontal cortex: relationship between 5-HT2A receptor density and associative learning.

Psychopharmacology 172(4) , 435-42, (2004)

Associative learning during classical trace eyeblink conditioning has been shown to be regulated by serotonin 5-HT(2A )receptors and to be critically dependent on the integrity of frontal cortex. Chro...

Effect of 5-HT2 receptor antagonists on a cranial nerve reflex in the rabbit: evidence for inverse agonism.

Psychopharmacology 141 , 162, (1999)

This study examined the role of the serotonin 5-HT2 receptor in motor function by examining the effect of antagonists on the motor performance of a cranial nerve reflex, the nictitating membrane (NM) ...

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Psychopharmacology 201(1) , 55-66, (2008)

The hallucinogenic tea known as ayahuasca is made from a combination of psychoactive plants that contribute the active components N,N-dimethyltryptamine (DMT) and 5-methoxy-DMT (5-MeO-DMT), as well as...

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