JNJ-31020028

• 常用名: JNJ-31020028
• 英文名: JNJ-31020028
• CAS号: 1094873-14-9
• 分子量: 565.680
• 密度: 1.2±0.1 g/cm3
• 沸点: 677.5±55.0 °C at 760 mmHg
• 分子式: C₃₄H₃₆FN₅O₂
• 熔点: N/A
• 闪点: 363.5±31.5 °C

JNJ-31020028用途

JNJ-31020028是神经肽Y2受体选择性可脑渗透抑制剂，对人Y2和鼠源Y2受体pIC50值分别为8.07和8.22，对人源Y1、Y4和Y5受体抑制作用要弱100倍以上。

JNJ-31020028名称

• 中文名: JNJ-31020028
• 英文名: N-[4-[4-[2-(diethylamino)-2-oxo-1-phenylethyl]piperazin-1-yl]-3-fluorophenyl]-2-pyridin-3-ylbenzamide

JNJ-31020028生物活性

• 描述: JNJ-31020028是神经肽Y2受体选择性可脑渗透抑制剂,对人Y2和鼠源Y2受体pIC50值分别为8.07和8.22,对人源Y1、Y4和Y5受体抑制作用要弱100倍以上。
• 相关类别:
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 神经肽Y受体
  研究领域 >> 神经疾病
• 参考文献:

  [1]. Shoblock JR, et al. In vitro and in vivo characterization of JNJ-31020028 (N-(4-{4-[2-(diethylamino)-2-oxo-1-phenylethyl]piperazin-1-yl}-3-fluorophenyl)-2-pyridin-3-ylbenzamide), a selective brain penetrant small molecule antagonist of the neuropeptide Y

  [2]. Cippitelli A, et al. The novel, selective, brain-penetrant neuropeptide Y Y2 receptor antagonist, JNJ-31020028, tested in animal models of alcohol consumption, relapse, and anxiety. Alcohol. 2011 Sep;45(6):567-76.

  [3]. Morales-Medina JC, et al. Chronic administration of the Y2 receptor antagonist, JNJ-31020028, induced anti-depressant like-behaviors in olfactory bulbectomized rat. Neuropeptides. 2012 Dec;46(6):329-34.

JNJ-31020028物理化学性质

• 密度: 1.2±0.1 g/cm3
• 沸点: 677.5±55.0 °C at 760 mmHg
• 分子式: C₃₄H₃₆FN₅O₂
• 分子量: 565.680
• 闪点: 363.5±31.5 °C
• 精确质量: 565.285278
• PSA: 72.27000
• LogP: 5.23
• InChIKey: OVUNRYUVDVWTTE-UHFFFAOYSA-N
• SMILES: CCN(CC)C(=O)C(c1ccccc1)N1CCN(c2ccc(NC(=O)c3ccccc3-c3cccnc3)cc2F)CC1
• 外观性状: white solid
• 蒸汽压: 0.0±2.1 mmHg at 25°C
• 折射率: 1.628
• 储存条件: -20℃

JNJ-31020028靶点实验

查看更多实验

实验名称：Primary qHTS assay for small molecule inhibitors of Inositol hexaphosphate kinase 1 (... 来源：NCGC External Id：IP6K1-p1

实验名称：Cytochrome P450 family 3 subfamily A member 4 (CYP3A4) small molecule antagonists: lu... 来源：NCGC External Id：CYP3A4437

实验名称：Metabolic stability in rat liver microsomes assessed as compound remaining after 15 m... 来源：ChEMBL 靶标：Liver microsomes External Id：CHEMBL2404389

实验名称：Cytochrome P450 family 2 subfamily D member 6 (CYP2D6) small molecule antagonists: lu... 来源：NCGC External Id：CYP2D6395

实验名称：Cytochrome P450 family 2 subfamily C member 9 (CYP2C9) small molecule antagonists: lu... 来源：NCGC External Id：CYP2C9536

实验名称：In vivo occupancy of NPYY5 receptor in sc dosed rat brain 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL3106333

实验名称：SARS-CoV-2 3CL-Pro protease inhibition percentage at 20µM by FRET kind of response f... 来源：ChEMBL 靶标：Replicase polyprotein 1ab External Id：CHEMBL4495582

实验名称：Half life in rat at 10 mg/kg, sc 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL3106335

实验名称：Metabolic stability in human liver microsomes assessed as compound remaining after 15... 来源：ChEMBL 靶标：Liver microsomes External Id：CHEMBL2404391

实验名称：Oral bioavailability in rat at 10 mg/kg 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL3106336

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JNJ-31020028英文别名

• N-(4-{4-[2-(Diethylamino)-2-oxo-1-phenylethyl]-1-piperazinyl}-3-fluorophenyl)-2-(3-pyridinyl)benzamide
• UNII:73F8XED6YP
• unii-73f8xed6yp
• JNJ 31020028
• JNJ31020028
• JNJ-31020028