Phleomycin D1

• 常用名: Phleomycin D1
• 英文名: Phleomycin D1
• CAS号: 11031-11-1
• 分子量: 1427.523
• 密度: 1.8±0.1 g/cm3
• 沸点: N/A
• 分子式: C₅₅H₈₆N₂₀O₂₁S₂
• 熔点: N/A
• 闪点: N/A

Phleomycin D1用途

静脉霉素D1(PLM D1)是一种糖肽抗生素,属于博莱霉素/静脉霉素家族。静脉霉素D1通过结合和切割DNA导致细胞死亡[1][2][3]。

Phleomycin D1名称

• 英文名: O0VC1NEK5M

Phleomycin D1生物活性

• 描述: 静脉霉素D1(PLM D1)是一种糖肽抗生素,属于博莱霉素/静脉霉素家族。静脉霉素D1通过结合和切割DNA导致细胞死亡[1][2][3]。
• 相关类别:
  研究领域 >> 感染
• 参考文献:

  [1]. Oliva-Trastoy M, et, al. Resistance to the antibiotic Zeocin by stable expression of the Sh ble gene does not fully suppress Zeocin-induced DNA cleavage in human cells. Mutagenesis. 2005 Mar;20(2):111-4.

  [2]. Ishizuka M, et, al. Studies on antitumor activity, antimicrobial activity and toxicity of phleomycin. J Antibiot (Tokyo). 1966 Nov;19(6):260-71.

  [3]. Huang CH, et, al. Bifunctional intercalation of antitumor antibiotics BBM-928A and echinomycin with deoxyribonucleic acid. Effects of intercalation on deoxyribonucleic acid degradative activity of bleomycin and phleomycin. Biochemistry. 1982 Jul 20;21(15):3704-10.

Phleomycin D1物理化学性质

• 密度: 1.8±0.1 g/cm3
• 分子式: C₅₅H₈₆N₂₀O₂₁S₂
• 分子量: 1427.523
• 精确质量: 1426.571777
• LogP: -4.76
• InChIKey: CWCMIVBLVUHDHK-ZSNHEYEWSA-N
• SMILES: Cc1c(N)nc(C(CC(N)=O)NCC(N)C(N)=O)nc1C(=O)NC(C(=O)NC(C)C(O)C(C)C(=O)NC(C(=O)NCCC1=NC(c2nc(C(=O)NCCCCN=C(N)N)cs2)CS1)C(C)O)C(OC1OC(CO)C(O)C(O)C1OC1OC(CO)C(O)C(OC(N)=O)C1O)c1cnc[nH]1
• 折射率: 1.769

Phleomycin D1英文别名

• (2R,3S,4S,5R,6R)-2-{[(2R,3S,4S,5S,6S)-2-[(1R,2S)-2-[({6-Amino-2-[(1S)-3-amino-1-{[(2S)-2,3-diamino-3-oxopropyl]amino}-3-oxopropyl]-5-methyl-4-pyrimidinyl}carbonyl)amino]-3-{[(2R,3S,4S)-5-({(2S,3R)-1-[(2-{(4'R)-4-[(4-carbamimidamidobutyl)carbamoyl]-4',5'-dihydro-2,4'-bi-1,3-thiazol-2'-yl}ethyl)amino]-3-hydroxy-1-oxo-2-butanyl}amino)-3-hydroxy-4-methyl-5-oxo-2-pentanyl]amino}-1-(1H-imidazol-4-yl)-3-oxopropoxy]-4,5-dihydroxy-6-(hydroxymethyl)t
• O0VC1NEK5M