依福地平

• 常用名: 依福地平
• 英文名: Efonidipine
• CAS号: 111011-63-3
• 分子量: 631.655
• 密度: 1.3±0.1 g/cm3
• 沸点: 746.9±60.0 °C at 760 mmHg
• 分子式: C₃₄H₃₈N₃O₇P
• 熔点: N/A
• 闪点: 405.5±32.9 °C

依福地平用途

Efonidipine(NZ-105)是T型和L型钙离子通道双重阻断剂。

依福地平名称

• 中文名: 依福地平
• 英文名: 2-(N-benzylanilino)ethyl 5-(5,5-dimethyl-2-oxo-1,3,2λ5-dioxaphosphinan-2-yl)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylate

依福地平生物活性

• 描述: Efonidipine(NZ-105)是T型和L型钙离子通道双重阻断剂。
• 相关类别:
  信号通路 >> 跨膜转运 >> 钙通道
  研究领域 >> 心血管疾病
• 参考文献:

  [1]. Ikeda K, et al. Efonidipine, a Ca(2+)-channel blocker, enhances the production of dehydroepiandrosterone sulfate in NCI-H295R human adrenocortical carcinoma cells. Tohoku J Exp Med. 2011;224(4):263-71.

  [2]. Nakano N, et al. Effects of efonidipine, an L- and T-type calcium channel blocker, on the renin-angiotensin-aldosterone system in chronic hemodialysis patients. Int Heart J. 2010 May;51(3):188-92.

  [3]. Suzuki S, et al. Beneficial effects of the dual L- and T-type Ca2+ channel blocker efonidipine on cardiomyopathic hamsters. Circ J. 2007 Dec;71(12):1970-6.

  [4]. Lee TS, et al. Actions of mibefradil, efonidipine and nifedipine block of recombinant T- and L-type Ca channels with distinct inhibitory mechanisms. Pharmacology. 2006;78(1):11-20.

依福地平物理化学性质

• 密度: 1.3±0.1 g/cm3
• 沸点: 746.9±60.0 °C at 760 mmHg
• 分子式: C₃₄H₃₈N₃O₇P
• 分子量: 631.655
• 闪点: 405.5±32.9 °C
• 精确质量: 631.244751
• PSA: 132.73000
• LogP: 6.99
• InChIKey: NSVFSAJIGAJDMR-UHFFFAOYSA-N
• SMILES: CC1=C(C(=O)OCCN(Cc2ccccc2)c2ccccc2)C(c2cccc([N+](=O)[O-])c2)C(P2(=O)OCC(C)(C)CO2)=C(C)N1
• 外观性状: 粉末
• 蒸汽压: 0.0±2.5 mmHg at 25°C
• 折射率: 1.625
• 储存条件: -20℃

依福地平靶点实验

查看更多实验

实验名称：qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signa... 来源：824 靶标：AR protein [Homo sapiens] External Id：MDAN535

实验名称：qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in... 来源：NCGC 靶标：TDP1 protein [Homo sapiens] External Id：TDP1100

实验名称：qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in... 来源：NCGC 靶标：TDP1 protein [Homo sapiens] External Id：TDP1101

实验名称：qHTS assay to identify small molecule antagonists of the androgen receptor (AR) sign... 来源：824 靶标：N/A External Id：MDAV150

实验名称：qHTS assay for small molecules that induce genotoxicity in human embryonic kidney cel... 来源：824 靶标：RecName: Full=ATPase family AAA domain-containing protein 5; AltName: Full=Chromosome fragility-associated gene 1 protein External Id：ELG271

实验名称：qHTS assay to identify small molecule antagonists of the thyroid receptor (TR) signal... 来源：824 靶标：thyroid hormone receptor beta isoform 2 [Rattus norvegicus] External Id：TRN186

实验名称：qHTS assay to identify small molecule antagonists of the thyroid receptor (TR) signal... 来源：824 靶标：N/A External Id：TRV455

实验名称：Inhibition of recombinant His6-tagged SARS-CoV-2 main protease using Dabcyl-KTSAVLQ-S... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4672895

实验名称：Inhibition of recombinant His6-tagged SARS-CoV-2 main protease assessed as residual e... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4672894

实验名称：Biochemical firefly luciferase enzyme assay for NPC 来源：NCGC 靶标：Luciferase [Photinus pyralis] External Id：adst-fluc-km-fda-o1_regid

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依福地平英文别名

• 2-[benzyl(phenyl)amino]ethyl 5-(5,5-dimethyl-2-oxo-1,3,2-dioxaphosphorinan-2-yl)-1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3-pyridinecarboxylate
• Efonidipine HCl
• 3-(benzyl-(phenyl)amino)ethyl-5-(5,5-dimethyl-2-oxo-1,3-dioxaphosphorinane-2-yl)-1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-pyridine
• 2-[Benzyl(phenyl)amino]ethyl (4S)-5-(5,5-dimethyl-2-oxido-1,3,2-dioxaphosphinan-2-yl)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydro-3-pyridinecarboxylate
• Efonidipine [INN]
• Efonidipine