达福普汀(甲磺酸盐)

• 常用名: 达福普汀(甲磺酸盐)
• 英文名: Dalfopristin
• CAS号: 112362-50-2
• 分子量: 690.84700
• 密度: 1.27g/cm3
• 沸点: 940.5ºC at 760 mmHg
• 分子式: C₃₄H₅₀N₄O₉S
• 熔点: N/A
• 闪点: 522.6ºC

达福普汀(甲磺酸盐)用途

Dalfopristin 是一种半合成的抗生素。Quinupristin/Dalfopristin (Q/D) 是 Vancomycin 有价值的替代抗生素,用于治疗耐多药性的 Enterococcus faecium 感染。

达福普汀(甲磺酸盐)名称

• 中文名: 达福普汀
• 英文名: Dalfopristin

达福普汀(甲磺酸盐)生物活性

• 描述: Dalfopristin 是一种半合成的抗生素。Quinupristin/Dalfopristin (Q/D) 是 Vancomycin 有价值的替代抗生素,用于治疗耐多药性的 Enterococcus faecium 感染。
• 相关类别:
  信号通路 >> 抗感染 >> 细菌
  研究领域 >> 感染
• 靶点实验:

  Antibacterial[1]

• 体外研究: Quinupristin/Dalfopristin(Q/D)是链霉素B(Quinupristin)和链霉素A(Dalfopristin)以30:70的比例组合[1]。 Quinupristin/Dalfopristin,一种半合成的可注射的链球菌素,是2种协同抗生素成分的组合,来源于原始霉素：B型链阳性菌素(Quinupristin)和A型链阳性菌素(Dalfopristin),重量比为30:70 [2]。
• 参考文献:

  [1]. Wang S, et al. Characteristic of Enterococcus faecium clinical isolates with quinupristin/Dalfopristin resistance in China. BMC Microbiol. 2016 Oct 21;16(1):246.

  [2]. Sacar M, et al. Comparison of antimicrobial agents as therapy for experimental endocarditis: caused by methicillin-resistant Staphylococcus aureus. Tex Heart Inst J. 2010;37(4):400-4.

达福普汀(甲磺酸盐)物理化学性质

• 密度: 1.27g/cm3
• 沸点: 940.5ºC at 760 mmHg
• 分子式: C₃₄H₅₀N₄O₉S
• 分子量: 690.84700
• 闪点: 522.6ºC
• 精确质量: 690.33000
• PSA: 184.80000
• LogP: 3.61680
• InChIKey: SUYRLXYYZQTJHF-PSUTZUHDSA-N
• SMILES: CCN(CC)CCS(=O)(=O)C1CCN2C(=O)c3coc(n3)CC(=O)CC(O)C=C(C)C=CCNC(=O)C=CC(C)C(C(C)C)OC(=O)C12
• 蒸汽压: 0mmHg at 25°C
• 折射率: 1.575
• 储存条件: 2-8℃

达福普汀(甲磺酸盐)靶点实验

查看更多实验

实验名称：Antimicrobial activity against methicillin resistant Staphylococcus aureus 181404 ass... 来源：ChEMBL 靶标：Staphylococcus aureus External Id：CHEMBL5536050

实验名称：Antimicrobial activity against vancomycin resistant Enterococcus faecium 310682 asses... 来源：ChEMBL 靶标：Enterococcus faecium External Id：CHEMBL5536049

实验名称：Antimicrobial activity against Staphylococcus aureus ATCC 29213 assessed as inhibitio... 来源：ChEMBL 靶标：Staphylococcus aureus External Id：CHEMBL5536048

实验名称：Antimicrobial activity against Pseudomonas aeruginosa ATCC 27853 assessed as inhibiti... 来源：ChEMBL 靶标：Pseudomonas aeruginosa External Id：CHEMBL5536047

实验名称：Antimicrobial activity against Escherichia coli ATCC 25922 assessed as inhibition of ... 来源：ChEMBL 靶标：Escherichia coli External Id：CHEMBL5536046

实验名称：Inhibition of mitochondrial translation in human COMI cells assessed as increase in C... 来源：ChEMBL 靶标：COMI External Id：CHEMBL5332873

实验名称：Antimicrobial activity against Klebsiella pneumoniae ATCC 700603 assessed as inhibiti... 来源：ChEMBL 靶标：Klebsiella pneumoniae External Id：CHEMBL5536045

实验名称：Antimicrobial activity against Candida tropicalis ATCC 1369 assessed as inhibition of... 来源：ChEMBL 靶标：Candida tropicalis External Id：CHEMBL5536044

实验名称：Inhibition of mitochondrial translation in human COMI cells assessed as decrease in C... 来源：ChEMBL 靶标：COMI External Id：CHEMBL5332871

实验名称：Antimicrobial activity against Candida albicans ATCC 10231 assessed as inhibition of ... 来源：ChEMBL 靶标：Candida albicans External Id：CHEMBL5536043

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