3'-去甲川陈皮素

• 常用名: 3'-去甲川陈皮素
• 英文名: 3'-Demethylnobiletin
• CAS号: 112448-39-2
• 分子量: 388.36800
• 密度: 1.304g/cm3
• 沸点: 613.8ºC at 760 mmHg
• 分子式: C₂₀H₂₀O₈
• 熔点: 170-171 ºC
• 闪点: 218.8ºC

3'-去甲川陈皮素用途

3'-Demethylnobiletin 是 Nobiletin 的一种衍生物,3'-Demethylnobiletin 是存在于柑橘类水果中的一种多甲氧基黄酮类化合物。Nobiletin 通过调节 Src,FAK 和 STAT3 信号传导来抗肿瘤,并抑制肿瘤血管生成。

3'-去甲川陈皮素名称

• 中文名: 3'-去甲川陈皮素
• 英文名: 2-(3-hydroxy-4-methoxyphenyl)-5,6,7,8-tetramethoxychromen-4-one

3'-去甲川陈皮素生物活性

• 描述: 3'-Demethylnobiletin 是 Nobiletin 的一种衍生物,3'-Demethylnobiletin 是存在于柑橘类水果中的一种多甲氧基黄酮类化合物。Nobiletin 通过调节 Src,FAK 和 STAT3 信号传导来抗肿瘤,并抑制肿瘤血管生成。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 其他 >> 其他
• 参考文献:

  [1]. Murakami A, et al. In vitro absorption and metabolism of nobiletin, a chemopreventive polymethoxyflavonoid in citrus fruits. Biosci Biotechnol Biochem. 2001 Jan;65(1):194-7.

  [2]. Sp N, et al. Nobiletin Inhibits Angiogenesis by Regulating Src/FAK/STAT3-Mediated Signaling through PXN in ER⁺ Breast Cancer Cells. Int J Mol Sci. 2017 Apr 30;18(5). pii: E935.

3'-去甲川陈皮素物理化学性质

• 密度: 1.304g/cm3
• 沸点: 613.8ºC at 760 mmHg
• 熔点: 170-171 ºC
• 分子式: C₂₀H₂₀O₈
• 分子量: 388.36800
• 闪点: 218.8ºC
• 精确质量: 388.11600
• PSA: 96.59000
• LogP: 3.20860
• InChIKey: XFYYZBJXMSDKCV-UHFFFAOYSA-N
• SMILES: COc1ccc(-c2cc(=O)c3c(OC)c(OC)c(OC)c(OC)c3o2)cc1O
• 外观性状: 粉末
• 蒸汽压: 1.17E-15mmHg at 25°C
• 折射率: 1.582
• 储存条件: 2-8°C，密封，干燥
• 水溶解性: Practically insoluble (0.039 g/L) (25 ºC)

3'-去甲川陈皮素靶点实验

查看更多实验

实验名称：Inhibition of TNFalpha-stimulated pro MMP9 production in human SRA 01/04 cells after ... 来源：ChEMBL 靶标：N/A External Id：CHEMBL1931997

实验名称：Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induc... 来源：ChEMBL 靶标：RAW264.7 External Id：CHEMBL923423

实验名称：Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induc... 来源：ChEMBL 靶标：RAW264.7 External Id：CHEMBL923424

实验名称：Inhibition of PMA-stimulated pro MMP9 production in human SRA 01/04 cells after 24 hr... 来源：ChEMBL 靶标：N/A External Id：CHEMBL1931999

实验名称：Cytotoxicity against mouse RAW264.7 cells at 30 uM by MTT assay 来源：ChEMBL 靶标：RAW264.7 External Id：CHEMBL923425

实验名称：Inhibition of LPS-induced iNOS gene expression in mouse RAW264.7 cells at 20 uM after... 来源：ChEMBL 靶标：RAW264.7 External Id：CHEMBL924470

实验名称：Inhibition of LPS-induced iNOS protein expression in mouse RAW264.7 cells at 5 uM aft... 来源：ChEMBL 靶标：RAW264.7 External Id：CHEMBL923426

实验名称：Cytotoxicity against human PMN cells at 100 uM 来源：ChEMBL 靶标：NON-PROTEIN TARGET External Id：CHEMBL905515

实验名称：Inhibition of LPS-induced iNOS protein expression in mouse RAW264.7 cells at 20 uM af... 来源：ChEMBL 靶标：RAW264.7 External Id：CHEMBL923427

共9条，当前第1页，共1页

1

3'-去甲川陈皮素英文别名

• 4H-1-Benzopyran-4-one,2-(3-hydroxy-4-methoxyphenyl)-5,6,7,8-tetramethoxy
• 3'-hydroxy-5,6,7,8,4'-pentamethoxyflavone
• 7-Hydroxy-3',4',5,6-tetramethoxyflavone
• 3'-Demethylnobiletin