GALANIN (RAT)

更新时间：2024-01-02 11:05:36

GALANIN (RAT)结构式	常用名	GALANIN (RAT)	英文名	Galanin (mouse, rat)
	CAS号	114547-31-8	分子量	3164.45000
	密度	N/A	沸点	N/A
	分子式	C₁₄₁H₂₁₁N₄₃O₄₁	熔点	N/A
	MSDS	中文版美版	闪点	N/A

GALANIN (RAT)用途

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Galanin (1-29)(rat, mouse) 是一种非选择性甘丙肽受体 (galanin receptor) 激动剂,对 GAL1、GAL2 和 GAL3 的 Ki 值分别为 0.98、1.48 和 1.47 nM。具有抗惊厥作用。

中文名	GALANIN (RAT)
英文名	Galanin (1-29) (rat, mouse)
英文别名	更多

描述	Galanin (1-29)(rat, mouse) 是一种非选择性甘丙肽受体 (galanin receptor) 激动剂,对 GAL1、GAL2 和 GAL3 的 Ki 值分别为 0.98、1.48 和 1.47 nM。具有抗惊厥作用。
相关类别	研究领域 >> 神经疾病信号通路 >> G 蛋白偶联受体/G 蛋白 >> 神经肽Y受体
参考文献	[1]. Wang S, et al. Cloning and expressional characterization of a novel galanin receptor. Identification of different pharmacophores within galanin for the three galanin receptor subtypes. J Biol Chem. 1997;272(51):31949-31952. [2]. Mazarati A, et al. Regulation of kindling epileptogenesis by hippocampal galanin type 1 and type 2 receptors: The effects of subtype-selective agonists and the role of G-protein-mediated signaling. J Pharmacol Exp Ther. 2006;318(2):700-708.

描述

Galanin (1-29)(rat, mouse) 是一种非选择性甘丙肽受体 (galanin receptor) 激动剂,对 GAL1、GAL2 和 GAL3 的 Ki 值分别为 0.98、1.48 和 1.47 nM。具有抗惊厥作用。

相关类别

研究领域 >> 神经疾病

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 神经肽Y受体

参考文献

[1]. Wang S, et al. Cloning and expressional characterization of a novel galanin receptor. Identification of different pharmacophores within galanin for the three galanin receptor subtypes. J Biol Chem. 1997;272(51):31949-31952.

[2]. Mazarati A, et al. Regulation of kindling epileptogenesis by hippocampal galanin type 1 and type 2 receptors: The effects of subtype-selective agonists and the role of G-protein-mediated signaling. J Pharmacol Exp Ther. 2006;318(2):700-708.

分子式	C₁₄₁H₂₁₁N₄₃O₄₁
分子量	3164.45000
精确质量	3162.57000
PSA	1347.03000
外观性状	白色冻干的粉末

个人防护装备	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
危险品运输编码	NONH for all modes of transport
WGK德国	3

Galanin is a paracrine inhibitor of gonadotroph function in the female rat.

Endocrinology 39 , 4222-4229, (1998)

Recent evidence suggests that pituitary galanin synthesized in the lactotroph is a paracrine regulator of lactotroph proliferation and PRL secretion and that these effects are mediated via a pituitary...

The GalR2 galanin receptor mediates galanin-induced jejunal contraction, but not feeding behavior, in the rat: differentiation of central and peripheral effects of receptor subtype activation.

FEBS Lett. 434 , 277-82, (1998)

The neuropeptide galanin mediates a diverse array of physiological functions through activation of specific receptors. Roles of the three recently cloned galanin receptors (GalRs) in rat intestinal co...

Pharmacological characterization of the contractile effects of galanin (1-29)-NH2, galantide and galanin (1-14)-(alpha-aminobutyric acid8)scyliorhinin-I in the rat gastric fundus.

Fundam. Clin. Pharmacol. 11 , 576, (1997)

Porcine galanin (1-29)-NH2, galantide (M15) and galanin (1-14)-(alpha-aminobutyric acid8)-scyliorhinin-I used in concentrations of 300, 1,000 and 3,000 nM respectively caused contractions of rat fundu...

GWTLNSAGYLLGPHAIDNHRSFSDKHGLT-NH2

GLY-TRP-THR-LEU-ASN-SER-ALA-GLY-TYR-LEU-LEU-GLY-PRO-HIS-ALA-ILE-ASP-ASN-HIS-ARG-SER-PHE-SER-ASP-LYS-HIS-GLY-LEU-THR-NH2

Rat galanin

H-Gly-Trp-Thr-Leu-Asn-Ser-Ala-Gly-Tyr-Leu-Leu-Gly-Pro-His-Ala-Ile-Asp-Asn-His-Arg-Ser-Phe-Ser-Asp-Lys-His-Gly-Leu-Thr-NH2

GALANIN,RAT