Lanopepden

更新时间：2025-08-25 18:35:23

Lanopepden结构式	常用名	Lanopepden	英文名	Lanopepden
	CAS号	1152107-25-9	分子量	479.54800
	密度	N/A	沸点	N/A
	分子式	C₂₂H₃₄FN₇O₄	熔点	N/A
	MSDS	N/A	闪点	N/A

Lanopepden用途

Lanopepden (GSK 1322322) 是一种肽去甲酰酶抑制剂,可抑制金黄色葡萄球菌。抑制 ATCC 29213 和 ATCC 25923 菌株,MIC 都为 1 mg/L。

中文名	Lanopepden
英文名	N-[(2R)-3-[2-[6-[(9aS)-3,4,6,7,9,9a-hexahydro-1H-pyrazino[2,1-c][1,4]oxazin-8-yl]-5-fluoro-2-methylpyrimidin-4-yl]hydrazinyl]-2-(cyclopentylmethyl)-3-oxopropyl]-N-hydroxyformamide
英文别名	更多

描述	Lanopepden (GSK 1322322) 是一种肽去甲酰酶抑制剂,可抑制金黄色葡萄球菌。抑制 ATCC 29213 和 ATCC 25923 菌株,MIC 都为 1 mg/L。
相关类别	研究领域 >> 感染信号通路 >> 抗感染 >> 细菌
参考文献	[1]. Peyrusson F, et al. Cellular pharmacokinetics and intracellular activity of the novel peptide deformylase inhibitor GSK1322322 against Staphylococcus aureus laboratory and clinical strains with various resistance phenotypes: studies with human THP-1 monocytes and J774 murine macrophages. Antimicrob Agents Chemother. 2015 Sep;59(9):5747-60.

分子式	C₂₂H₃₄FN₇O₄
分子量	479.54800
精确质量	479.26600
PSA	126.65000
LogP	2.48420
储存条件	2-8℃

实验名称：Antibacterial activity against methicillin-sensitive Staphylococcus epidermidis 14-1
来源：ChEMBL
靶标：Staphylococcus epidermidis
External Id：CHEMBL3826593

实验名称：Antibacterial activity against methicillin-sensitive Staphylococcus epidermidis 14-2
来源：ChEMBL
靶标：Staphylococcus epidermidis
External Id：CHEMBL3826594

实验名称：Antibacterial activity against methicillin-sensitive Staphylococcus epidermidis 14-3
来源：ChEMBL
靶标：Staphylococcus epidermidis
External Id：CHEMBL3826595

实验名称：Antibacterial activity against Enterococcus faecalis 14-1
来源：ChEMBL
靶标：Enterococcus faecalis
External Id：CHEMBL3826596

实验名称：Antibacterial activity against methicillin-resistant Staphylococcus epidermidis 14-1
来源：ChEMBL
靶标：Staphylococcus epidermidis
External Id：CHEMBL3826589

实验名称：Antibacterial activity against methicillin-resistant Staphylococcus epidermidis 14-2
来源：ChEMBL
靶标：Staphylococcus epidermidis
External Id：CHEMBL3826590

实验名称：Antibacterial activity against methicillin-resistant Staphylococcus epidermidis 14-3
来源：ChEMBL
靶标：Staphylococcus epidermidis
External Id：CHEMBL3826591

实验名称：Antibacterial activity against methicillin-resistant Staphylococcus epidermidis 14-4
来源：ChEMBL
靶标：Staphylococcus epidermidis
External Id：CHEMBL3826592

实验名称：Antibacterial activity against Escherichia coli 14-2
来源：ChEMBL
靶标：Escherichia coli
External Id：CHEMBL3826601

实验名称：Half life in rat at 8.5 mg/kg, po
来源：ChEMBL
靶标：N/A
External Id：CHEMBL4434157

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