SKF96067

• 常用名: SKF96067
• 英文名: SKF96067
• CAS号: 115607-61-9
• 分子量: 334.41200
• 密度: 1.162g/cm3
• 沸点: 473.2ºC at 760mmHg
• 分子式: C₂₁H₂₂N₂O₂
• 熔点: N/A
• 闪点: 240ºC

SKF96067用途

SKF96067 是一种可逆的 H^+/K^+-ATPase 抑制剂。

SKF96067名称

• 中文名: SKF96067
• 英文名: 1-[8-methoxy-4-(2-methylanilino)quinolin-3-yl]butan-1-one

SKF96067生物活性

• 描述: SKF96067 是一种可逆的 H+/K+-ATPase 抑制剂。
• 相关类别:
  信号通路 >> 跨膜转运 >> 质子泵
  研究领域 >> 其他
• 体外研究: 相对于活化作用K +,SKF96067竞争性地抑制K +刺激的ATP酶活性,Ki值为0.39±0.05μM。 SKF96067还抑制氢离子传输。在100 mM NaCl和1 mM KCl存在下,SKF96067在pH 7.0下抑制ATP酶活性,IC50值为60±10μM[1]。
• 参考文献:

  [1]. Keeling DJ, et al. SK&F 96067 is a reversible, lumenally acting inhibitor of the gastric (H+ + K+)-ATPase. Biochem Pharmacol. 1991 Jun 21;42(1):123-30.

SKF96067物理化学性质

• 密度: 1.162g/cm3
• 沸点: 473.2ºC at 760mmHg
• 分子式: C₂₁H₂₂N₂O₂
• 分子量: 334.41200
• 闪点: 240ºC
• 精确质量: 334.16800
• PSA: 51.22000
• LogP: 5.35120
• InChIKey: MAVJDLHBPIXVJL-UHFFFAOYSA-N
• SMILES: CCCC(=O)c1cnc2c(OC)cccc2c1Nc1ccccc1C
• 蒸汽压: 4E-09mmHg at 25°C
• 折射率: 1.63
• 储存条件: 2-8℃

SKF96067靶点实验

查看更多实验

实验名称：Inhibition of histamine stimulated gastric acid secretion was tested in heidenhain po... 来源：ChEMBL 靶标：Canis lupus familiaris External Id：CHEMBL671193

实验名称：Inhibition of pentagastrin-stimulated gastric acid secretion in the anesthetized rat ... 来源：ChEMBL 靶标：Potassium-transporting ATPase subunit beta External Id：CHEMBL781386

实验名称：Compound was tested in vivo for gastric antisecretory activity after 5 hr of pylorus ... 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL779934

实验名称：Histamine-stimulated gastric acid secretion in Heidenhain pouch dog at 1uM/Kg, on iv ... 来源：ChEMBL 靶标：Canis lupus familiaris External Id：CHEMBL669899

实验名称：Concentration required to inhibit the activity of K+ stimulated gastric ATPase 来源：ChEMBL 靶标：Potassium-transporting ATPase subunit beta External Id：CHEMBL875664

实验名称：Histamine-stimulated gastric acid secretion in Heidenhain pouch dog at 4uM/Kg, on iv ... 来源：ChEMBL 靶标：Canis lupus familiaris External Id：CHEMBL669900

实验名称：Compound was tested in vitro for H+/K+ ATPase activity in rabbit stomach preparations 来源：ChEMBL 靶标：Potassium-transporting ATPase alpha chain 1 External Id：CHEMBL686816

实验名称：Mean percent peak inhibition of histamine-stimulated gastric acid secretion in the he... 来源：ChEMBL 靶标：Canis lupus familiaris External Id：CHEMBL668449

实验名称：Mean percent peak inhibition of histamine-stimulated gastric acid secretion in the he... 来源：ChEMBL 靶标：Canis lupus familiaris External Id：CHEMBL669480

实验名称：Inhibition of K+ -stimulated gastric ATPase activity was measured using lyophilized g... 来源：ChEMBL 靶标：Potassium-transporting ATPase subunit beta External Id：CHEMBL688289

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SKF96067英文别名

• SKF96067