γ-分泌酶调节剂1

• 常用名: γ-分泌酶调节剂1
• 英文名: gamma-secretase modulator 1
• CAS号: 1172637-87-4
• 分子量: 416.53900
• 密度: 1.3
• 沸点: N/A
• 分子式: C₂₄H₂₄N₄OS
• 熔点: N/A
• 闪点: N/A

γ-分泌酶调节剂1用途

γ-secretase inhibitior-1是γ-secretase调节剂,可作用于阿尔茨海默病。

γ-分泌酶调节剂1名称

• 中文名: 4,5,6,7-四氢-N-[3-甲氧基-4-(4-甲基-1H-咪唑-1-基)苯基]-4-苯基-2-苯并噻唑胺
• 英文名: N-[3-methoxy-4-(4-methylimidazol-1-yl)phenyl]-4-phenyl-4,5,6,7-tetrahydro-1,3-benzothiazol-2-amine

γ-分泌酶调节剂1生物活性

• 描述: γ-secretase inhibitior-1是γ-secretase调节剂,可作用于阿尔茨海默病。
• 相关类别:
  信号通路 >> 神经信号通路 >> γ分泌酶
  信号通路 >> 干细胞及 Wnt 通路 >> γ分泌酶
  研究领域 >> 神经疾病
• 参考文献:

  [1]. Baumann, Karlheinz; Flohr, Alexander; Preparation of 4,5,6,7-tetrahydrobenzothiazolyl- or 5,6,7,8-tetrahydroquinazolinylphenylamine derivatives as modulators for amyloid beta. PCT Int. Appl. (2009), 111pp. CODEN: PIXXD2 WO 2009087127 A1

γ-分泌酶调节剂1物理化学性质

• 密度: 1.3
• 分子式: C₂₄H₂₄N₄OS
• 分子量: 416.53900
• 精确质量: 416.16700
• PSA: 83.44000
• LogP: 5.27950
• InChIKey: VFSGAZRYSCNFDF-UHFFFAOYSA-N
• SMILES: COc1cc(Nc2nc3c(s2)CCCC3c2ccccc2)ccc1-n1cnc(C)c1
• 储存条件: 2-8℃

γ-分泌酶调节剂1靶点实验

查看更多实验

实验名称：Primary qHTS assay for small molecule inhibitors of Inositol hexaphosphate kinase 1 (... 来源：NCGC External Id：IP6K1-p1

实验名称：Cytochrome P450 family 3 subfamily A member 4 (CYP3A4) small molecule antagonists: lu... 来源：NCGC External Id：CYP3A4437

实验名称：Ratio of drug level in brain to plasma in transgenic mouse overexpressing APP Swedish... 来源：ChEMBL 靶标：Nucleic Acid External Id：CHEMBL1921621

实验名称：Cytochrome P450 family 2 subfamily D member 6 (CYP2D6) small molecule antagonists: lu... 来源：NCGC External Id：CYP2D6395

实验名称：AUC (0 to 24 hrs) in transgenic mouse overexpressing APP Swedish FAD mutant at 7.2 mg... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL1921620

实验名称：Cytochrome P450 family 2 subfamily C member 9 (CYP2C9) small molecule antagonists: lu... 来源：NCGC External Id：CYP2C9536

实验名称：Antialzheimer activity in po dosed transgenic mouse overexpressing APP Swedish FAD mu... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL1921624

实验名称：Inhibition of gamma secretase assessed as reduction in Abeta42 production 来源：ChEMBL 靶标：N/A External Id：CHEMBL2155446

实验名称：Antialzheimer activity in transgenic mouse overexpressing APP Swedish FAD mutant asse... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL1919638

实验名称：NCATS Human Liver Microsomal (HLM) Stability Profiling 来源：NCGC 靶标：N/A External Id：ADME-HLM1

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γ-分泌酶调节剂1英文别名

• [3-methoxy-4-(4-methylimidazol-1-yl)phenyl]-(4-phenyl-4,5,6,7-tetrahydrobenzothiazol-2-yl)amine
• gamma-secretase modulator 1