AMG-337

• 常用名: AMG-337
• 英文名: AMG-337
• CAS号: 1173699-31-4
• 分子量: 463.464
• 密度: 1.4±0.1 g/cm3
• 沸点: N/A
• 分子式: C₂₃H₂₂FN₇O₃
• 熔点: N/A
• 闪点: N/A

AMG-337用途

AMG-337是一种有效的高度选择性的ATP竞争性MET激酶抑制剂, IC50 < 5 nM。

AMG-337名称

• 中文名: AMG-337
• 英文名: amg-337

AMG-337生物活性

• 描述: AMG-337是一种有效的高度选择性的ATP竞争性MET激酶抑制剂, IC50 < 5 nM。
• 相关类别:
  信号通路 >> 蛋白酪氨酸激酶 >> c-Met的/HGFR
  研究领域 >> 癌症
• 参考文献:

  [1]. Paul E. Hughes, et al. AMG 337, a novel, potent and selective MET kinase inhibitor, has robust growth inhibitory activity in MET-dependent cancer models. Cancer Res October 1, 2014 74; 728

  [2]. Cecchi F, et al. Targeting the HGF/Met signaling pathway in cancer therapy. Expert Opin Ther Targets. 2012 Jun;16(6):553-572.

AMG-337物理化学性质

• 密度: 1.4±0.1 g/cm3
• 分子式: C₂₃H₂₂FN₇O₃
• 分子量: 463.464
• 精确质量: 463.176819
• PSA: 101.36000
• LogP: 1.42
• InChIKey: DWHXUGDWKAIASB-CQSZACIVSA-N
• SMILES: COCCOc1cnc2ccn(C(C)c3nnc4c(F)cc(-c5cnn(C)c5)cn34)c(=O)c2c1
• 外观性状: 粉末
• 折射率: 1.689
• 储存条件: -20℃

AMG-337安全信息

• 危害码 (欧洲): N

AMG-337靶点实验

查看更多实验

实验名称：NCATS Kinetic Aqueous Solubility Profiling 来源：NCGC 靶标：N/A External Id：ADME-solubility1

实验名称：Primary qHTS assay for small molecule inhibitors of Inositol hexaphosphate kinase 1 (... 来源：NCGC External Id：IP6K1-p1

实验名称：Cytotoxicity counterscreen for inhibitors of SARS-CoV-2 cell entry 来源：NCGC 靶标：N/A External Id：TRND-SARS-CoV-2-cytotox-48hr

实验名称：Primary qHTS to identify inhibitors of SARS-CoV-2 cell entry 来源：NCGC External Id：TRND-SARS-CoV-2-PP

实验名称：Human MET proto-oncogene, receptor tyrosine kinase (Type X RTKs: HGF (hepatocyte grow... 来源：IUPHAR-DB 靶标：MET proto-oncogene, receptor tyrosine kinase (Type X RTKs: HGF (hepatocyte growth factor) receptor family) [Homo sapiens] External Id：1815_Human

实验名称：NCATS Parallel Artificial Membrane Permeability Assay (PAMPA) Profiling 来源：NCGC 靶标：N/A External Id：ADME-PAMPA1

实验名称：qHTS assay to identify novel small-molecules to repurpose for Merkel cell carcinoma t... 来源：NCGC 靶标：N/A External Id：MCC011

实验名称：Primary qHTS for Identification of Calcium Integrin Binding Protein 1 (CIB1) Competit... 来源：NCGC External Id：CIB1-p1-p2

实验名称：Cytotoxic Profiling of Annotated Libraries Using Quantitative High-Throughput Screeni... 来源：NCGC 靶标：N/A External Id：CPF001

实验名称：Oral bioavailability in Sprague-Dawley rat at 2 mg/kg 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL3788760

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AMG-337英文别名

• 6-{(1R)-1-[8-Fluoro-6-(1-methyl-1H-pyrazol-4-yl)[1,2,4]triazolo[4,3-a]pyridin-3-yl]ethyl}-3-(2-methoxyethoxy)-1,6-naphthyridin-5(6H)-one
• AMG337
• (R)-6-(1-(8-fluoro-6-(1-methyl-1H-pyrazol-4-yl)-[1,2,4]triazolo[4,3-a]pyridin-3-yl)ethyl)-3-(2-methoxyethoxy)-1,6-naphthyridin-5(6H)-one